The Molecular Biophysics & Biochemistry (MBB) discipline in the Integrated Biomedical Sciences (IBMS) Graduate Program at UT Health San Antonio is a dynamic program that is heavily focused on studying the structure and function of cellular components and how they interact in complex regulatory networks that control many processes, including DNA repair, critical in cancer and aging, protein folding and assembly, central to many processes, and intercellular signaling that underlie cancer and metabolic disorders, such as diabetes.
The program is supported by state-of-the-art facilities for structural biology (X-ray crystallography, NMR spectroscopy, and biophysical methods for studying the dynamics of intermolecular interactions), systems biology (proteomics and metabolomics) and a Center for Innovative Drug Discovery (CIDD) all hosted within the department of Biochemistry and Structural Biology. The CIDD, a joint venture with UTSA that is comprised of both high throughput screening and medicinal chemistry cores, has been central to the development of several promising new drug candidates in areas ranging from parasitic disease to cancer.
Recent technological advances have revolutionized the way we discover and characterize molecular pathways, identify mutations linked to different diseases, and develop new drugs to combat them. Our ability to convert our unprecedented insight into effective individualized therapeutics requires mechanistic understanding of the key molecules involved, their interactions with partners, and the way their function is regulated. The MBB Discipline provides a unique environment in which graduate students contribute to the cutting-edge science in seek of new innovative therapeutics, while receiving training in the most sophisticated research tools available to modern biochemistry.
Dr. Rui J. Sousa