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Doug Frantz, PhD

Adjoint Professor

Education

1994-1998 Doctor of Philosophy, Organic Chemistry, Texas A&M University, College Station, TX
Advisor: Professor Daniel A. Singleton
PhD Thesis: Synthetic and Mechanistic Studies of Carbometalation Reactions
1990-1994 Bachelor of Science, Chemistry, Stephen F. Austin State University, Nacogdoches, TX

Research

Areas of Specialization
1. Medicinal Chemistry
2. Process Chemistry
3. Asymmetric Catalysis
4. Heterocyclic Synthesis
5. Physical Organic Chemistry
6. Frantz Research Group

Research Interests

The centralized theme of research in my lab involves the application and development of new synthetic methodology in organic chemistry that can provide new avenues of chemical reactivity while keeping practicality as a viable and equally important goal. Many of the reactions we develop are mediated by late-transition metals catalysts that are fine-tuned through the use of real-time quantitative techniques allowing us to rapidly screen new reactions and parameters with unparalleled efficiency in academia. Furthermore, my lab is also involved with several medicinal chemistry programs aimed at developing new small molecule probes towards studying the mechanisms of stem cell differentiation. Students in my lab learn techniques in synthetic chemistry, medicinal chemistry, analytical chemistry, physical organic chemistry and drug discovery and development.

Publications

  • An alternative polyamine biosynthetic pathway is widespread in bacteria and essential for biofilm formation in Vibrio cholerae
    Lee, J.; Sperandio, V.; Frantz, D. E.; Longgood, J.; Camilli, A.; Phillips, M. A.; Michael, A. J.
    J. Biol. Chem.: 2009-01-01; (284); 9899
    PMID:    LINK:
  • Small-molecule activation of neuronal cell fate.
    Schneider, J. W.; Gao, Z.; Li, S.; Farooqi, M.; Tang, T., -S.; Bezprozvanny, I.; Frantz, D. E.; Hsieh, J.
    Nature Chem. Bio.: 2008-01-01; (4); 408
    PMID:    LINK:
  • Stereoselective synthesis of acetoacetate-derived enol triflates.
    Babinski, D.; Soltani, O.; Frantz, D. E
    Org. Lett.: 2008-01-01; (10); 2901
    PMID:    LINK:
  • Cardiogenic small molecules that enhance myocardial repair by stem cells.
    Sadek, H.; Hannack, B.; Choe, E.; Wang, J.; Latif, S.; Garry, M. G.; Garry, D. J.; Longgood, J.; Frantz, D. E.; Olson, E. N.; Hsieh, J,; Schneider, J. W.
    Proc. Natl. Acad. Sci. U.S.A.: 2008-01-01; (105); 6063-6068
    PMID:    LINK:
  • Substitution effect on the regioselective halogen/metal exchange of 3-substituted 1,2,5-tribromobenzenes
    Menzel, K.; Mills, P. M.; Frantz, D. E.; Nelson, T. D.; Kress, M. H.
    Tetrahedron Lett.: 2008-01-01; (49); 415-418
    PMID:    LINK: