Mark Shapiro

Professor- Department of Physiology

Personal Statement:

My research program has spanned the physiology and modulation of voltage-gated K+ and Ca2+ channels in neurons, cardiomyocytes, smooth muscle and non-excitable cells. We have focused on voltage-gated �M-type� (KCNQ) K+, Ca2+, and TrpV sensory channels and signaling pathways of Gq/11-coupled receptors, using patch-clamp electrophysiology of native neurons and heterologous systems, biochemistry, confocal and TIRF microscopy, molecular biology and live single-cell and whole-animal imaging. Our major publications have shown the PIP2 sensitivity of both types of channels, the mechanisms and structural determinants of receptor-mediated suppression of IM and ICa, the modulation of KCNQ channels by calmodulin, A-kinase anchoring proteins (AKAPs) and Src kinase, the roles of M channels during ischemia/hypoxia or epileptic seizures in the brain, in airway smooth muscle, and in sensory neurons. We also seek to systematically explore the role of AKAP79/150 in orchestrating transcriptional and regulator


B.A., Physics, University of Chicago, 1984
Ph.D., Physiology, Rush University Medical Center, 1991
Post Doctoral: University of Washington, Department of Physiology and Biophysics


1. Modulation of KCNQ (M-type) K+ channels by lipids, calcium/calmodulin and protein kinase C.
2. Role of A-kinase Anchoring Protein 79/150 in regulation of M channels, calcium channels and TRPV channels.
3. Neuroprotective role of KCNQ/M channels during ischemic stroke and traumatic brain injury.
4. Role of KCNQ channels in airway smooth muscle and KCNQ openers as anti-asthmatic therapy.
5. Ion channels regulating excitability in nodose ganglia that innervate visceral organs.
6. STORM super-resolution optical microscopy in the detection of multi-protein comoplexes.
7. TRPM7 ion channels in cancer.