Location: GCCRI 04.100.08

Yogesh Gupta, PhD

Assistant Professor


Ph.D., Structural Biology, Magnetic Resonance Center (CERM), University of Florence, Florence, Italy
M.Tech., Biotechnology, Anna University, Chennai, India
M.Sc., Biochemistry, Agra University, Agra, India
Post Doctoral: Mount Sinai School of Medicine, New York, NY
Cross Appointments: Greehey Children's Cancer Research Institute


Research Interest:

The Gupta lab studies the structure and function of protein-nucleic acid assemblies central to normal homeostasis and childhood cancers. We are particularly interested in understanding the exact mechanisms by which different enzymes and accessory factors cross talk, assemble, and install various covalent chemical modifications on their RNA targets. These post-transcriptional modifications regulate cellular fate decisions including oncogenic transformation of cancer cells. Our long-term goal is to understand the nature of subunit assemblies and sub cellular localization of the entire human RNA methylome. We employ a powerful combination of structural biology tools such as X-ray crystallography, NMR, coupled with array of other biophysical, in silico, and cell based methods to address prevailing questions on this emerging field of RNA epigenetics. Our studies are expected to elucidate the role of RNA methylome and its potential as a novel anticancer target.
We are also pursuing structural and mechanistic studies on selective ATP motors that process abnormal nucleic acid structures to maintain genome integrity. These ATP motors appear to play direct role in disease progression including pediatric brain tumors.

If interested in applying, please email your CV with names of 3 references to

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Structural Insights into nucleic acid-protein interactions Protein-Nucleic Acid Interactions in Normal Homeostasis & Cancer