{"id":503,"date":"2018-05-09T14:42:41","date_gmt":"2018-05-09T14:42:41","guid":{"rendered":"https:\/\/wp.uthscsa.edu\/biochemistry\/?page_id=503"},"modified":"2021-01-12T17:31:59","modified_gmt":"2021-01-12T23:31:59","slug":"technology","status":"publish","type":"page","link":"https:\/\/lsom.uthscsa.edu\/biochemistry\/core-facilities\/xray-core\/technology\/","title":{"rendered":"Technology (X-ray Crystallography Core Laboratory)"},"content":{"rendered":"

[vc_row el_class=”far”][vc_column width=”2\/3″][vc_column_text]The X-ray Crystallography Core Laboratory at UT Health San Antonio offers state-of-the-art macromolecular X-ray crystallographic instrumentation operating on a collaborative use basis. The equipment infrastructure of the facility presently includes two complete X-ray crystallography systems:<\/p>\n

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  1. Rigaku R-AXIS HTC imaging plate area detector with VariMax HighFlux optics mounted on a high-flux MIcroMax 007HF generator with an X-STREAM cryogenic crystal cooling system<\/li>\n
  2. Rigaku R-AXIS HTC imaging plate area detector with VariMax HighRes optics mounted on a high-flux MIcroMax 007HF generator with an X-STREAM cryogenic crystal cooling system<\/li>\n<\/ol>\n

    The improved brilliance of the 007HF equipped with VariMax optics relative to conventional home lab X-ray sources gives researchers the in-house capability to work with very small or poorly diffracting crystals. Computational hardware (Intel Quad-core Linux workstations) and software (CNS, CCP4, COOT, d*TREK, HKL-2000, PHENIX, SHARP, SHELX, etc.) are also in place enabling the complete protein structure determination and refinement process to be accomplished in relatively short order.[\/vc_column_text][\/vc_column][vc_column width=”1\/3″]