{"id":3494,"date":"2021-06-16T16:17:50","date_gmt":"2021-06-16T21:17:50","guid":{"rendered":"https:\/\/lsom.uthscsa.edu\/family-medicine\/?page_id=3494"},"modified":"2022-02-08T10:07:17","modified_gmt":"2022-02-08T16:07:17","slug":"dpp-4-inhibitors-and-glp-1-agonists-the-perfect-pairing-or-better-off-alone","status":"publish","type":"page","link":"https:\/\/lsom.uthscsa.edu\/family-medicine\/dpp-4-inhibitors-and-glp-1-agonists-the-perfect-pairing-or-better-off-alone\/","title":{"rendered":"DPP-4 Inhibitors And GLP-1 Agonists: The Perfect Pairing, Or Better Off Alone?"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row][vc_column width=&#8221;2\/3&#8243;][vc_column_text]<\/p>\n<h3>Overview:<\/h3>\n<p>Type 2 diabetes mellitus (T2DM) is one of the most common disease states encountered in primary care, affecting 10.6% of patients in Bexar County. The incretin agents, DPP-4 inhibitors and GLP-1 agonists, are used for the treatment of T2DM by promoting glucose-dependent insulin release by different mechanisms. The purpose of this presentation is to determine the safety and potential for synergy of dual incretin therapy by reviewing the available literature.<\/p>\n<h3>Objectives:<\/h3>\n<ol>\n<li>\u00a0 Describe the role of incretins in the pathophysiology of type 2 diabetes mellitus (T2DM)<\/li>\n<li>\u00a0 Review the pharmacology and place in therapy for dipeptidyl peptidase 4 (DPP-4) inhibitors and glucagon-like peptide-1 (GLP-1) agonists<\/li>\n<li>\u00a0 Formulate an evidence-based recommendation regarding the use of both incretin agents in the treatment of T2DM<\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/lsom.uthscsa.edu\/family-medicine\/wp-content\/uploads\/sites\/75\/2021\/05\/EricaTorres2020.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-3451\" src=\"https:\/\/lsom.uthscsa.edu\/family-medicine\/wp-content\/uploads\/sites\/75\/2021\/05\/EricaTorres2020.jpg\" alt=\"Erica Torres, PharmD\" width=\"250\" height=\"250\" \/><\/a>Erica L. Torres, PharmD<br \/>\nPGY2 Ambulatory Care Pharmacy Resident<br \/>\nDepartment of Pharmacotherapy &amp; Pharmacy Services<br \/>\nUniversity Health[\/vc_column_text][vc_column_text]<\/p>\n<h3>Financial Disclosures:<\/h3>\n<p>Erica L. Torres, PharmD and her faculty mentor DeWayne Davidson, PharmD have no relevant financial relationships with commercial interests to disclose.<\/p>\n<p>The Family &amp; Community Medicine Professional Development and Grand Rounds Committee members (Marcy Wiemers, MD, Maria Del Pilar Monta\u00f1ez Villacampa, MD, Christine Song, DO, Nehman Andry, MD, Margaret Finley, Maureen Alvarado, DO, Richel Avery, MD, Inez I. Cruz, PhD, and Nichole Rubio) have no relevant financial relationships to commercial interests to disclose.<\/p>\n<p>The Family &amp; Community Medicine Professional Development and Grand Rounds Committee member Carlos Roberto Ja\u00e9n, MD has disclosed he receives royalties from General Practice and Family Medicine for being UpToDate Editor-in-Chief.<\/p>\n<h3>Credits:<\/h3>\n<p><em>AMA PRA Category 1 Credits<\/em>\u2122 (1.00 hours), Non-Physician Participation Credit (1.00 hours)<\/p>\n<h3>Target Audience:<\/h3>\n<p>Specialties \u2013 Primary Care; Family Medicine<br \/>\nFaculty, residents, other health care providers and staff from our department; physicians and health care providers from San Antonio and South Texas; and medical students in our third-year clerkship and fourth year rotations.<\/p>\n<h3>Accreditation:<\/h3>\n<p>The UT Health Long San Antonio School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.<\/p>\n<h3>Credit Designation:<\/h3>\n<p>The Long School of Medicine designates this live activity up to a maximum of <em>1.00 AMA PRA Category 1 Credits<\/em>\u2122.<\/p>\n<p>Physicians should claim only the credit commensurate with the extent of their participation in the activity.<\/p>\n<p>Nurses and other healthcare professionals will receive a Certificate of Attendance. For information on applicability and acceptance, please consult your professional licensing board.[\/vc_column_text][\/vc_column][vc_column width=&#8221;1\/3&#8243;] \n        <a class=\"panel no-equilizer panel-mobile text-center colorized colorized-institutional\" href=\"https:\/\/cmetracker.net\/UTHSCSA\/Login?formname=regLoginLive&EventID=10087348\" title=\"\" target=\"\">\n            <span class=\"circle close2x mid-icon\"><span><i class=\"icon-checkbox-checked\"><\/i><\/span><\/span><br>\n            <h3 >View Recording (CME Credit)<\/h3>\n            <p><\/p>\n        <\/a> \n        <a class=\"panel no-equilizer panel-mobile text-center colorized colorized-academics\" href=\"https:\/\/youtu.be\/Qre4otAMWhw\" title=\"\" target=\"\">\n            <span class=\"circle close2x mid-icon\"><span><i class=\"icon-uth-shield\"><\/i><\/span><\/span><br>\n            <h3 >View Recording (no CME Credit)<\/h3>\n            <p><\/p>\n        <\/a>[vc_column_text]For activity related questions, please contact:<br \/>\nName: Nichole Rubio- FCM Grand Rounds Coordinator<br \/>\nEmail:\u00a0<a href=\"mailto:rubion@uthscsa.edu\">rubion@uthscsa.edu<\/a><\/p>\n<p>For CME general questions, please contact<br \/>\nPh: (210) 567-4445<br \/>\nEmail: <a href=\"mailto:cme@uthscsa.edu\">cme@uthscsa.edu<\/a>[\/vc_column_text][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column width=&#8221;2\/3&#8243;][vc_column_text] Overview: Type 2 diabetes mellitus (T2DM) is one of the most common disease states encountered in primary care, affecting 10.6% of patients in Bexar County. The incretin agents, DPP-4 inhibitors and GLP-1 agonists, are used for the treatment of T2DM by promoting glucose-dependent insulin release by different mechanisms. The purpose of this presentation [&hellip;]<\/p>\n","protected":false},"author":245,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-3494","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>DPP-4 Inhibitors And GLP-1 Agonists: The Perfect Pairing, Or Better Off Alone? - Family and Community Medicine<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/lsom.uthscsa.edu\/family-medicine\/dpp-4-inhibitors-and-glp-1-agonists-the-perfect-pairing-or-better-off-alone\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"DPP-4 Inhibitors And GLP-1 Agonists: The Perfect Pairing, Or Better Off Alone? - Family and Community Medicine\" \/>\n<meta property=\"og:description\" content=\"[vc_row][vc_column width=&#8221;2\/3&#8243;][vc_column_text] Overview: Type 2 diabetes mellitus (T2DM) is one of the most common disease states encountered in primary care, affecting 10.6% of patients in Bexar County. The incretin agents, DPP-4 inhibitors and GLP-1 agonists, are used for the treatment of T2DM by promoting glucose-dependent insulin release by different mechanisms. The purpose of this presentation [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/lsom.uthscsa.edu\/family-medicine\/dpp-4-inhibitors-and-glp-1-agonists-the-perfect-pairing-or-better-off-alone\/\" \/>\n<meta property=\"og:site_name\" content=\"Family and Community Medicine\" \/>\n<meta property=\"article:modified_time\" content=\"2022-02-08T16:07:17+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/lsom.uthscsa.edu\/family-medicine\/wp-content\/uploads\/sites\/75\/2021\/05\/EricaTorres2020.jpg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/lsom.uthscsa.edu\\\/family-medicine\\\/dpp-4-inhibitors-and-glp-1-agonists-the-perfect-pairing-or-better-off-alone\\\/\",\"url\":\"https:\\\/\\\/lsom.uthscsa.edu\\\/family-medicine\\\/dpp-4-inhibitors-and-glp-1-agonists-the-perfect-pairing-or-better-off-alone\\\/\",\"name\":\"DPP-4 Inhibitors And GLP-1 Agonists: The Perfect Pairing, Or Better Off Alone? - Family and Community Medicine\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/lsom.uthscsa.edu\\\/family-medicine\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/lsom.uthscsa.edu\\\/family-medicine\\\/dpp-4-inhibitors-and-glp-1-agonists-the-perfect-pairing-or-better-off-alone\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/lsom.uthscsa.edu\\\/family-medicine\\\/dpp-4-inhibitors-and-glp-1-agonists-the-perfect-pairing-or-better-off-alone\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/lsom.uthscsa.edu\\\/family-medicine\\\/wp-content\\\/uploads\\\/sites\\\/75\\\/2021\\\/05\\\/EricaTorres2020.jpg\",\"datePublished\":\"2021-06-16T21:17:50+00:00\",\"dateModified\":\"2022-02-08T16:07:17+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/lsom.uthscsa.edu\\\/family-medicine\\\/dpp-4-inhibitors-and-glp-1-agonists-the-perfect-pairing-or-better-off-alone\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/lsom.uthscsa.edu\\\/family-medicine\\\/dpp-4-inhibitors-and-glp-1-agonists-the-perfect-pairing-or-better-off-alone\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/lsom.uthscsa.edu\\\/family-medicine\\\/dpp-4-inhibitors-and-glp-1-agonists-the-perfect-pairing-or-better-off-alone\\\/#primaryimage\",\"url\":\"https:\\\/\\\/lsom.uthscsa.edu\\\/family-medicine\\\/wp-content\\\/uploads\\\/sites\\\/75\\\/2021\\\/05\\\/EricaTorres2020.jpg\",\"contentUrl\":\"https:\\\/\\\/lsom.uthscsa.edu\\\/family-medicine\\\/wp-content\\\/uploads\\\/sites\\\/75\\\/2021\\\/05\\\/EricaTorres2020.jpg\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/lsom.uthscsa.edu\\\/family-medicine\\\/dpp-4-inhibitors-and-glp-1-agonists-the-perfect-pairing-or-better-off-alone\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/lsom.uthscsa.edu\\\/family-medicine\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"DPP-4 Inhibitors And GLP-1 Agonists: The Perfect Pairing, Or Better Off Alone?\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/lsom.uthscsa.edu\\\/family-medicine\\\/#website\",\"url\":\"https:\\\/\\\/lsom.uthscsa.edu\\\/family-medicine\\\/\",\"name\":\"Family and Community Medicine\",\"description\":\"Department of Family &amp; Community Medicine\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/lsom.uthscsa.edu\\\/family-medicine\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"DPP-4 Inhibitors And GLP-1 Agonists: The Perfect Pairing, Or Better Off Alone? - Family and Community Medicine","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/lsom.uthscsa.edu\/family-medicine\/dpp-4-inhibitors-and-glp-1-agonists-the-perfect-pairing-or-better-off-alone\/","og_locale":"en_US","og_type":"article","og_title":"DPP-4 Inhibitors And GLP-1 Agonists: The Perfect Pairing, Or Better Off Alone? - Family and Community Medicine","og_description":"[vc_row][vc_column width=&#8221;2\/3&#8243;][vc_column_text] Overview: Type 2 diabetes mellitus (T2DM) is one of the most common disease states encountered in primary care, affecting 10.6% of patients in Bexar County. 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