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Mansour M. Zadeh, PhD

Distinguished Professor

Personal Statement:

Dr. Mansour M. Zadeh is a cellular and molecular immunologist. Dr. Zadeh is a Distinguished Professor in Medicine and the Director of The Center for Mucosal & Microbiome Biology at the UT Health San Antonio – Joe R. & Teresa Lozano Long School of Medicine. His laboratory’s work is tightly focused on the interaction of gut microbiome and the associated metabolites (e.g., vitamin B12) with the hosts during steady states and proinflmammatory diseases such as inflammatory bowel disease (IBD). Dr. Zadeh’s goal is to robustly establish an advanced scientific platform in cellular and molecular mucosal immunology and microbiome research by supporting the education of both basic and clinical scientists. Dr. Zadeh’s research and educational endeavors are geared toward creating an environment that facilitates a commitment to innovative research excellence and patient care.


Education

Doctor of Philosophy in Cellular & Molecular Immunology
1991 · Johannes Gutenberg University

Master of Science in Cellular & Molecular Immunology
1989 · Johannes Gutenberg University

Bachelor of Science in Cellular & Molecular Biology
1986 · Johannes Gutenberg University/Germany

Research

Mansour M. Zadeh is a distinguished professor in medicine with over 27 years of expertise in the fields of mucosal inflammation, infectious diseases, microbiome, and the related metabolisms. His scientific focus is tightly centered on the genomic, and physiological reprogramming of the fate of intestinal epithelial cells, and tissue resident phagocytic cells through gut microbiome, and the associated metabolites. His work elucidates the interaction of the cells with commensals, and the associated gene products (e.g., surface layers, metabolites), and the subsequent differential regulation of naïve T lymphocytes into bacterial antigen-specific Th17 cells or extrathymic regulatory T cells (Tregs) in health, and inflammatory bowel disease (IBD). He employs multiomic profiling approaches to delve into the involved molecular mechanisms underlying the regulation of gut homeostasis that is highly controlled via bidirectional interactions with microbial species, and the associated metabolites, particularly vitamin B12 (VB12).  Gaining insights into such a complex interplay requires rigid multiomic disciplines, including transcriptomic, metabolomic, and epigenomic approaches to potentially identify the transcriptional regulation to protect hosts against  proinflammatory diseases (IBD).