{"id":5165,"date":"2022-08-31T11:33:38","date_gmt":"2022-08-31T16:33:38","guid":{"rendered":"https:\/\/lsom.uthscsa.edu\/mimg\/?p=5165"},"modified":"2022-09-02T13:58:43","modified_gmt":"2022-09-02T18:58:43","slug":"ann-griffith-phd-and-na-ziong-phd-publish-paper-in-journal-of-immunology","status":"publish","type":"post","link":"https:\/\/lsom.uthscsa.edu\/mimg\/2022\/08\/31\/ann-griffith-phd-and-na-ziong-phd-publish-paper-in-journal-of-immunology\/","title":{"rendered":"Ann Griffith, PhD and Na Xiong, PhD publish paper in Journal of Immunology"},"content":{"rendered":"

Congratulations to Dr. Griffith and Dr. Xiong for their Journal of Immunology publication, Delta-like 4\u2013Derived Notch Signals Differentially Regulate Thymic Generation of Skin-Homing CCR10+NK1.1+ Innate Lymphoid Cells at Neonatal and Adult Stages<\/a><\/p>\n

The thymus is a primary lymphoid organ for T cell development. Increasing evidence found that the thymus is also an important site for development of innate lymphoid cells (ILCs). ILCs generated in thymi acquire unique homing properties that direct their localization into barrier tissues such as the skin and intestine, where they help local homeostasis. Mechanisms underlying the developmental programming of unique tissue-homing properties of ILCs are poorly understood. We report in this article that thymic stroma-derived Notch signaling is differentially involved in thymic generation of a population of NK1.1+\u00a0group 1 ILCs (ILC1s) with the CCR10+\u00a0skin-homing property in adult and neonatal mice. We found that thymic generation of CCR10+NK1.1+\u00a0ILC1s is increased in T cell\u2013deficient mice at adult, but not neonatal, stages, supporting the notion that a large number of developing T cells interfere with signals required for generation of CCR10+NK1.1+\u00a0ILC1s. In an in\u00a0vitro differentiation assay, increasing Notch signals promotes generation of CCR10+NK1.1+\u00a0ILC1s from hematopoietic progenitors. Knockout of the Notch ligand Delta-like 4 in thymic stroma impairs generation of CCR10+NK1.1+\u00a0ILC1s in adult thymi, but development of CCR10+NK1.1+\u00a0ILC1s in neonatal thymi is less dependent on Delta-like 4\u2013derived Notch signals. Mechanistically, the Notch signaling is required for proper expression of the IL-7R CD127 on thymic NK1.1+\u00a0ILC1s, and deficiency of CD127 also impairs thymic generation of CCR10+NK1.1+\u00a0ILC1s at adult, but not perinatal, stages. Our findings advanced understanding of regulatory mechanisms of thymic innate lymphocyte development.<\/p>\n

Eun Hyeon Song, Ming Xu, Jie Yang, Yangming Xiao, Ann V. Griffith and Na Xiong<\/p>\n

J Immunol\u00a0August 3, 2022,\u00a0ji2100870;\u00a0DOI: https:\/\/doi.org\/10.4049\/jimmunol.2100870<\/p>\n","protected":false},"excerpt":{"rendered":"

Congratulations to Dr. Griffith and Dr. Xiong for their Journal of Immunology publication, Delta-like 4\u2013Derived Notch Signals Differentially Regulate Thymic Generation of Skin-Homing CCR10+NK1.1+ Innate Lymphoid Cells at Neonatal and Adult Stages The thymus is a primary lymphoid organ for T cell development. Increasing evidence found that the thymus is also an important site for […]<\/p>\n","protected":false},"author":318,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[28],"tags":[],"class_list":["post-5165","post","type-post","status-publish","format-standard","hentry","category-news"],"yoast_head":"\nAnn Griffith, PhD and Na Xiong, PhD publish paper in Journal of Immunology - Microbiology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/lsom.uthscsa.edu\/mimg\/2022\/08\/31\/ann-griffith-phd-and-na-ziong-phd-publish-paper-in-journal-of-immunology\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Ann Griffith, PhD and Na Xiong, PhD publish paper in Journal of Immunology - Microbiology\" \/>\n<meta property=\"og:description\" content=\"Congratulations to Dr. Griffith and Dr. Xiong for their Journal of Immunology publication, Delta-like 4\u2013Derived Notch Signals Differentially Regulate Thymic Generation of Skin-Homing CCR10+NK1.1+ Innate Lymphoid Cells at Neonatal and Adult Stages The thymus is a primary lymphoid organ for T cell development. 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