{"id":1203,"date":"2020-02-28T20:19:53","date_gmt":"2020-02-28T20:19:53","guid":{"rendered":"https:\/\/lsom.uthscsa.edu\/molecular-medicine\/?p=1203"},"modified":"2020-05-18T16:47:53","modified_gmt":"2020-05-18T16:47:53","slug":"nomination-for-the-2019-cancer-center-discovery-of-the-year-congratulations-to-dr-jason-liu","status":"publish","type":"post","link":"https:\/\/lsom.uthscsa.edu\/molecular-medicine\/2020\/02\/28\/nomination-for-the-2019-cancer-center-discovery-of-the-year-congratulations-to-dr-jason-liu\/","title":{"rendered":"Nomination for the 2019 Cancer Center Discovery of the Year &#8211; Congratulations to Dr. Jason Liu"},"content":{"rendered":"<p>Dr. Jason Liu has been nominated for the Mays Cancer Center 2019 Discovery of the Year Award for his publication, A non-canonical role of YAP\/TEAD is required for activation of estrogen-regulated enhancers in breast cancer, in <em>Molecular Cell<\/em>.<\/p>\n<p>Abstract:<\/p>\n<p>YAP and TEAD are nuclear effectors of the Hippo signaling pathway that regulates organ size and tumorigenesis through their chromatin-associated functions on gene promoters. In this study, Dr. Liu and his trainees unveil a non-canonical function of these nuclear factors in gene expression germane for understanding breast cancer development and progression. Specifically, through proteomics and other molecular analyses,\u00a0a novel function of YAP1 and TEAD4 as co-regulators of estrogen\/ER\u03b1 responsive genes is found. Importantly, YAP and TEAD act as critical scaffolding elements in assembling a higher order protein complex needed for enhancer activity. These findings thus reveal a new role of YAP and TEAD in gene expression via an enhancer-specific function, and they also contribute toward delineating the basis of cancer cell growth that is driven by the expression of estrogen\/ER\u03b1 responsive genes. Moreover, this study highlights the potential of targeting YAP\/TEAD in the treatment of ER\u03b1-positive breast cancer.<\/p>\n<p>&nbsp;<\/p>\n<p>Chi Zhu, Li Li, Zhao Zhang, Mingjun Bi, Hu Wang, Wenyue Su, Karen Hernandez, Pingping Liu, Junqiang Chen, Mingqiu Chen, Tim Hui-Ming Huang, Lizhen Chen and <strong>Zhijie Liu<\/strong>*. A non-canonical role of YAP\/TEAD is required for activation of estrogen-regulated enhancers in breast cancer. Molecular Cell. 2019 Aug 22;75(4):791-806. PMID: 31303470 (*lead author)<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Dr. Jason Liu has been nominated for the Mays Cancer Center 2019 Discovery of the Year Award for his publication, A non-canonical role of YAP\/TEAD is required for activation of estrogen-regulated enhancers in breast cancer, in Molecular Cell. Abstract: YAP and TEAD are nuclear effectors of the Hippo signaling pathway that regulates organ size and [&hellip;]<\/p>\n","protected":false},"author":264,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"class_list":["post-1203","post","type-post","status-publish","format-standard","hentry","category-highimpactpublication"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Nomination for the 2019 Cancer Center Discovery of the Year - Congratulations to Dr. Jason Liu - Department of Molecular Medicine<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/lsom.uthscsa.edu\/molecular-medicine\/2020\/02\/28\/nomination-for-the-2019-cancer-center-discovery-of-the-year-congratulations-to-dr-jason-liu\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Nomination for the 2019 Cancer Center Discovery of the Year - Congratulations to Dr. Jason Liu - Department of Molecular Medicine\" \/>\n<meta property=\"og:description\" content=\"Dr. Jason Liu has been nominated for the Mays Cancer Center 2019 Discovery of the Year Award for his publication, A non-canonical role of YAP\/TEAD is required for activation of estrogen-regulated enhancers in breast cancer, in Molecular Cell. Abstract: YAP and TEAD are nuclear effectors of the Hippo signaling pathway that regulates organ size and [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/lsom.uthscsa.edu\/molecular-medicine\/2020\/02\/28\/nomination-for-the-2019-cancer-center-discovery-of-the-year-congratulations-to-dr-jason-liu\/\" \/>\n<meta property=\"og:site_name\" content=\"Department of Molecular Medicine\" \/>\n<meta property=\"article:published_time\" content=\"2020-02-28T20:19:53+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-05-18T16:47:53+00:00\" \/>\n<meta name=\"author\" content=\"Allan Jenkins\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Allan Jenkins\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/lsom.uthscsa.edu\\\/molecular-medicine\\\/2020\\\/02\\\/28\\\/nomination-for-the-2019-cancer-center-discovery-of-the-year-congratulations-to-dr-jason-liu\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/lsom.uthscsa.edu\\\/molecular-medicine\\\/2020\\\/02\\\/28\\\/nomination-for-the-2019-cancer-center-discovery-of-the-year-congratulations-to-dr-jason-liu\\\/\"},\"author\":{\"name\":\"Allan Jenkins\",\"@id\":\"https:\\\/\\\/lsom.uthscsa.edu\\\/molecular-medicine\\\/#\\\/schema\\\/person\\\/f9ba93501ec712deeae4be817f0910a7\"},\"headline\":\"Nomination for the 2019 Cancer Center Discovery of the Year &#8211; 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