{"id":1248,"date":"2020-08-25T21:55:34","date_gmt":"2020-08-25T21:55:34","guid":{"rendered":"https:\/\/lsom.uthscsa.edu\/molecular-medicine\/?p=1248"},"modified":"2020-09-08T15:04:13","modified_gmt":"2020-09-08T15:04:13","slug":"cprit-awards-mays-cancer-center-more-than-10-3-million","status":"publish","type":"post","link":"https:\/\/lsom.uthscsa.edu\/molecular-medicine\/2020\/08\/25\/cprit-awards-mays-cancer-center-more-than-10-3-million\/","title":{"rendered":"CPRIT awards Mays Cancer Center more than $10.3 million"},"content":{"rendered":"<p>Mingjiang Xu, MD, PhD, professor of molecular medicine and the San Antonio Cancer Council Distinguished Chair in Oncology, will receive an Individual Investigator Award of $900,000. The topic is \u201cRole of HOTTIP lncRNA in Leukemogenesis.\u201d<\/p>\n<p>Dr. Xu is interested in long non-coding RNAs, which if dysregulated play major roles in the development and progression of many cancers. One of these molecules is HOTTIP, and Dr. Xu\u2019s team seeks to understand its role in leukemia initiation.<\/p>\n<p>For more information, please click\u00a0<a href=\"https:\/\/news.uthscsa.edu\/cprit-awards-mays-cancer-center-more-than-10-3-million\/\" target=\"_blank\" rel=\"noopener noreferrer\">here.<\/a><\/p>\n<p>&nbsp;<\/p>\n<p>Summary:<\/p>\n<p>Long non-coding RNAs (lncRNAs) influence many critical cellular processes such as gene expression. The initiation and progression of myeloid leukemia have thus far been studied mainly within the realm of mutations and\/or dysregulation of key protein-coding genes. Whether lncRNAs affect the initiation and progression of malignant myelopoiesis remains to be determined. In addition, elucidating the mechanistic roles of oncogenic lncRNAs will provide the intellectual and experimental framework for developing targeted therapeutics for myeloid leukemia. We have initiated efforts to identify pivotal oncogenic lncRNAs in the pathogenesis of myeloid leukemia. This endeavor has yielded highly promising candidates including HOTTIP, and this application is aimed at elucidating the mechanistic roles of HOTTIP in myeloid leukemia. We have established the requisite methods and animal models for the successful completion of this project, which include unbiased library screening for candidate lncRNAs, long range chromosome interactions, and mapping lncRNA genomic binding sites. The proposed studies will clarify the role of HOTTIP lncRNA in leukemogenesis, hematopoietic stem cell (HSC) behavior and gene regulation. We will elucidate the molecular mechanism(s) by which HOTTIP regulates chromatin conformation and expression of target genes important for HSC and leukemogenesis using genome-wide chromatin modifications and interactions, transcription profiles, as well as loss-of-function and gain-of-function studies. In addition, we will explore whether this lncRNA can serve as a therapeutic target for AML patients with HOTTIP overexpression. The proposed studies will capitalize on the complementary scientific expertise offered by the UTHSA collaborators. These studies will fill an important knowledge gap concerning oncogenic lncRNAs in myeloid leukemia and their mechanisms of action. Our findings will lead to innovative and novel therapeutic targets\/strategies against myeloid leukemia.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Mingjiang Xu, MD, PhD, professor of molecular medicine and the San Antonio Cancer Council Distinguished Chair in Oncology, will receive an Individual Investigator Award of $900,000. The topic is \u201cRole of HOTTIP lncRNA in Leukemogenesis.\u201d Dr. Xu is interested in long non-coding RNAs, which if dysregulated play major roles in the development and progression of [&hellip;]<\/p>\n","protected":false},"author":264,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[14],"class_list":["post-1248","post","type-post","status-publish","format-standard","hentry","category-news"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>CPRIT awards Mays Cancer Center more than $10.3 million - Department of Molecular Medicine<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/lsom.uthscsa.edu\/molecular-medicine\/2020\/08\/25\/cprit-awards-mays-cancer-center-more-than-10-3-million\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"CPRIT awards Mays Cancer Center more than $10.3 million - Department of Molecular Medicine\" \/>\n<meta property=\"og:description\" content=\"Mingjiang Xu, MD, PhD, professor of molecular medicine and the San Antonio Cancer Council Distinguished Chair in Oncology, will receive an Individual Investigator Award of $900,000. The topic is \u201cRole of HOTTIP lncRNA in Leukemogenesis.\u201d Dr. Xu is interested in long non-coding RNAs, which if dysregulated play major roles in the development and progression of [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/lsom.uthscsa.edu\/molecular-medicine\/2020\/08\/25\/cprit-awards-mays-cancer-center-more-than-10-3-million\/\" \/>\n<meta property=\"og:site_name\" content=\"Department of Molecular Medicine\" \/>\n<meta property=\"article:published_time\" content=\"2020-08-25T21:55:34+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-09-08T15:04:13+00:00\" \/>\n<meta name=\"author\" content=\"Allan Jenkins\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Allan Jenkins\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/lsom.uthscsa.edu\\\/molecular-medicine\\\/2020\\\/08\\\/25\\\/cprit-awards-mays-cancer-center-more-than-10-3-million\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/lsom.uthscsa.edu\\\/molecular-medicine\\\/2020\\\/08\\\/25\\\/cprit-awards-mays-cancer-center-more-than-10-3-million\\\/\"},\"author\":{\"name\":\"Allan Jenkins\",\"@id\":\"https:\\\/\\\/lsom.uthscsa.edu\\\/molecular-medicine\\\/#\\\/schema\\\/person\\\/f9ba93501ec712deeae4be817f0910a7\"},\"headline\":\"CPRIT awards Mays Cancer Center more than $10.3 million\",\"datePublished\":\"2020-08-25T21:55:34+00:00\",\"dateModified\":\"2020-09-08T15:04:13+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/lsom.uthscsa.edu\\\/molecular-medicine\\\/2020\\\/08\\\/25\\\/cprit-awards-mays-cancer-center-more-than-10-3-million\\\/\"},\"wordCount\":367,\"articleSection\":[\"News\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/lsom.uthscsa.edu\\\/molecular-medicine\\\/2020\\\/08\\\/25\\\/cprit-awards-mays-cancer-center-more-than-10-3-million\\\/\",\"url\":\"https:\\\/\\\/lsom.uthscsa.edu\\\/molecular-medicine\\\/2020\\\/08\\\/25\\\/cprit-awards-mays-cancer-center-more-than-10-3-million\\\/\",\"name\":\"CPRIT awards Mays Cancer Center more than $10.3 million - Department of Molecular Medicine\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/lsom.uthscsa.edu\\\/molecular-medicine\\\/#website\"},\"datePublished\":\"2020-08-25T21:55:34+00:00\",\"dateModified\":\"2020-09-08T15:04:13+00:00\",\"author\":{\"@id\":\"https:\\\/\\\/lsom.uthscsa.edu\\\/molecular-medicine\\\/#\\\/schema\\\/person\\\/f9ba93501ec712deeae4be817f0910a7\"},\"breadcrumb\":{\"@id\":\"https:\\\/\\\/lsom.uthscsa.edu\\\/molecular-medicine\\\/2020\\\/08\\\/25\\\/cprit-awards-mays-cancer-center-more-than-10-3-million\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/lsom.uthscsa.edu\\\/molecular-medicine\\\/2020\\\/08\\\/25\\\/cprit-awards-mays-cancer-center-more-than-10-3-million\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/lsom.uthscsa.edu\\\/molecular-medicine\\\/2020\\\/08\\\/25\\\/cprit-awards-mays-cancer-center-more-than-10-3-million\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/lsom.uthscsa.edu\\\/molecular-medicine\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"News\",\"item\":\"https:\\\/\\\/lsom.uthscsa.edu\\\/molecular-medicine\\\/category\\\/news\\\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"CPRIT awards Mays Cancer Center more than $10.3 million\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/lsom.uthscsa.edu\\\/molecular-medicine\\\/#website\",\"url\":\"https:\\\/\\\/lsom.uthscsa.edu\\\/molecular-medicine\\\/\",\"name\":\"Department of Molecular Medicine\",\"description\":\"Department of Molecular Medicine\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/lsom.uthscsa.edu\\\/molecular-medicine\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/lsom.uthscsa.edu\\\/molecular-medicine\\\/#\\\/schema\\\/person\\\/f9ba93501ec712deeae4be817f0910a7\",\"name\":\"Allan Jenkins\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/c7b37b4cc45d6f6a6b6862b1ab3ead86ed46ac67359c67d9613da381b7a18125?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/c7b37b4cc45d6f6a6b6862b1ab3ead86ed46ac67359c67d9613da381b7a18125?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/c7b37b4cc45d6f6a6b6862b1ab3ead86ed46ac67359c67d9613da381b7a18125?s=96&d=mm&r=g\",\"caption\":\"Allan Jenkins\"},\"url\":\"https:\\\/\\\/lsom.uthscsa.edu\\\/molecular-medicine\\\/author\\\/jenkinsallan\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"CPRIT awards Mays Cancer Center more than $10.3 million - Department of Molecular Medicine","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/lsom.uthscsa.edu\/molecular-medicine\/2020\/08\/25\/cprit-awards-mays-cancer-center-more-than-10-3-million\/","og_locale":"en_US","og_type":"article","og_title":"CPRIT awards Mays Cancer Center more than $10.3 million - Department of Molecular Medicine","og_description":"Mingjiang Xu, MD, PhD, professor of molecular medicine and the San Antonio Cancer Council Distinguished Chair in Oncology, will receive an Individual Investigator Award of $900,000. The topic is \u201cRole of HOTTIP lncRNA in Leukemogenesis.\u201d Dr. Xu is interested in long non-coding RNAs, which if dysregulated play major roles in the development and progression of [&hellip;]","og_url":"https:\/\/lsom.uthscsa.edu\/molecular-medicine\/2020\/08\/25\/cprit-awards-mays-cancer-center-more-than-10-3-million\/","og_site_name":"Department of Molecular Medicine","article_published_time":"2020-08-25T21:55:34+00:00","article_modified_time":"2020-09-08T15:04:13+00:00","author":"Allan Jenkins","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Allan Jenkins","Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/lsom.uthscsa.edu\/molecular-medicine\/2020\/08\/25\/cprit-awards-mays-cancer-center-more-than-10-3-million\/#article","isPartOf":{"@id":"https:\/\/lsom.uthscsa.edu\/molecular-medicine\/2020\/08\/25\/cprit-awards-mays-cancer-center-more-than-10-3-million\/"},"author":{"name":"Allan Jenkins","@id":"https:\/\/lsom.uthscsa.edu\/molecular-medicine\/#\/schema\/person\/f9ba93501ec712deeae4be817f0910a7"},"headline":"CPRIT awards Mays Cancer Center more than $10.3 million","datePublished":"2020-08-25T21:55:34+00:00","dateModified":"2020-09-08T15:04:13+00:00","mainEntityOfPage":{"@id":"https:\/\/lsom.uthscsa.edu\/molecular-medicine\/2020\/08\/25\/cprit-awards-mays-cancer-center-more-than-10-3-million\/"},"wordCount":367,"articleSection":["News"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/lsom.uthscsa.edu\/molecular-medicine\/2020\/08\/25\/cprit-awards-mays-cancer-center-more-than-10-3-million\/","url":"https:\/\/lsom.uthscsa.edu\/molecular-medicine\/2020\/08\/25\/cprit-awards-mays-cancer-center-more-than-10-3-million\/","name":"CPRIT awards Mays Cancer Center more than $10.3 million - Department of Molecular Medicine","isPartOf":{"@id":"https:\/\/lsom.uthscsa.edu\/molecular-medicine\/#website"},"datePublished":"2020-08-25T21:55:34+00:00","dateModified":"2020-09-08T15:04:13+00:00","author":{"@id":"https:\/\/lsom.uthscsa.edu\/molecular-medicine\/#\/schema\/person\/f9ba93501ec712deeae4be817f0910a7"},"breadcrumb":{"@id":"https:\/\/lsom.uthscsa.edu\/molecular-medicine\/2020\/08\/25\/cprit-awards-mays-cancer-center-more-than-10-3-million\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/lsom.uthscsa.edu\/molecular-medicine\/2020\/08\/25\/cprit-awards-mays-cancer-center-more-than-10-3-million\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/lsom.uthscsa.edu\/molecular-medicine\/2020\/08\/25\/cprit-awards-mays-cancer-center-more-than-10-3-million\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/lsom.uthscsa.edu\/molecular-medicine\/"},{"@type":"ListItem","position":2,"name":"News","item":"https:\/\/lsom.uthscsa.edu\/molecular-medicine\/category\/news\/"},{"@type":"ListItem","position":3,"name":"CPRIT awards Mays Cancer Center more than $10.3 million"}]},{"@type":"WebSite","@id":"https:\/\/lsom.uthscsa.edu\/molecular-medicine\/#website","url":"https:\/\/lsom.uthscsa.edu\/molecular-medicine\/","name":"Department of Molecular Medicine","description":"Department of Molecular Medicine","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/lsom.uthscsa.edu\/molecular-medicine\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Person","@id":"https:\/\/lsom.uthscsa.edu\/molecular-medicine\/#\/schema\/person\/f9ba93501ec712deeae4be817f0910a7","name":"Allan Jenkins","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/secure.gravatar.com\/avatar\/c7b37b4cc45d6f6a6b6862b1ab3ead86ed46ac67359c67d9613da381b7a18125?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c7b37b4cc45d6f6a6b6862b1ab3ead86ed46ac67359c67d9613da381b7a18125?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/c7b37b4cc45d6f6a6b6862b1ab3ead86ed46ac67359c67d9613da381b7a18125?s=96&d=mm&r=g","caption":"Allan Jenkins"},"url":"https:\/\/lsom.uthscsa.edu\/molecular-medicine\/author\/jenkinsallan\/"}]}},"_links":{"self":[{"href":"https:\/\/lsom.uthscsa.edu\/molecular-medicine\/wp-json\/wp\/v2\/posts\/1248","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lsom.uthscsa.edu\/molecular-medicine\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lsom.uthscsa.edu\/molecular-medicine\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lsom.uthscsa.edu\/molecular-medicine\/wp-json\/wp\/v2\/users\/264"}],"replies":[{"embeddable":true,"href":"https:\/\/lsom.uthscsa.edu\/molecular-medicine\/wp-json\/wp\/v2\/comments?post=1248"}],"version-history":[{"count":0,"href":"https:\/\/lsom.uthscsa.edu\/molecular-medicine\/wp-json\/wp\/v2\/posts\/1248\/revisions"}],"wp:attachment":[{"href":"https:\/\/lsom.uthscsa.edu\/molecular-medicine\/wp-json\/wp\/v2\/media?parent=1248"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lsom.uthscsa.edu\/molecular-medicine\/wp-json\/wp\/v2\/categories?post=1248"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}