{"id":2488,"date":"2021-09-24T14:20:28","date_gmt":"2021-09-24T19:20:28","guid":{"rendered":"https:\/\/lsom.uthscsa.edu\/nephrology\/?page_id=2488"},"modified":"2021-12-13T12:04:43","modified_gmt":"2021-12-13T18:04:43","slug":"clinical-research-trials","status":"publish","type":"page","link":"https:\/\/lsom.uthscsa.edu\/nephrology\/research\/clinical-research-trials\/","title":{"rendered":"Clinical Trials"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row][vc_column][vc_column_text]Clinical trials, also known as research studies or patient studies, are essential in the fight against kidney diseases. These human studies help physician-scientists better understand, diagnose, treat and prevent diseases and conditions. UT Health San Antonio- Division of Nephrology conducts numerous clinical trials and research studies on a wide spectrum of kidney diseases including acute kidney injury, diabetic nephropathy and cardiorenal syndromes. Two landmark long term, NIH sponsored, multi-center clinical trials are actively following the subjects in the Division: The Diabetes Prevention Program Outcomes Study (DPPOS) and Look AHEAD (Action for Health in Diabetes). In addition, our faculty participate in several industry-sponsored clinical trials. Our patients\u2019 participation have contributed significantly to the success of recently completed trials evaluating newer cardiorenal protective drugs such as Atrasentan in SONAR, Canagliflozin in CREDENCE, Finerernone in FIDELO and FIGARO, and ongoing study with Empaglifozin in EMPA-Kidney.<\/p>\n<p>Following studies are open for enrollment to participants who want to volunteer for research studies related to kidney health and disease.<\/p>\n<div class=\"row wide-gutter\">\n\t<div class=\"columns large-4 medium-4 small-12 push-8\">\n      <form autocomplete=\"off\" name=\"wpv-filter-2490\" action=\"\/nephrology\/wp-json\/wp\/v2\/pages\/2488?wpv_view_count=2490\" method=\"get\" class=\"wpv-filter-form js-wpv-filter-form js-wpv-filter-form-2490 js-wpv-form-full\" data-viewnumber=\"2490\" data-viewid=\"2490\" data-viewhash=\"eyJuYW1lIjoiZmluZC1hLWNsaW5pY2FsLXRyaWFsIn0=\" data-viewwidgetid=\"0\" data-orderby=\"\" data-order=\"\" data-orderbyas=\"\" data-orderbysecond=\"\" 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data-attributes=\"[]\" data-environment=\"{&quot;current_post_id&quot;:2488,&quot;parent_post_id&quot;:2488,&quot;parent_term_id&quot;:0,&quot;parent_user_id&quot;:0,&quot;archive&quot;:{&quot;type&quot;:&quot;&quot;,&quot;name&quot;:&quot;&quot;,&quot;data&quot;:[]}}\"><input type=\"hidden\" class=\"js-wpv-dps-filter-data js-wpv-filter-data-for-this-form\" data-action=\"\/nephrology\/wp-json\/wp\/v2\/pages\/2488?wpv_view_count=2490\" data-page=\"1\" data-ajax=\"disable\" data-effect=\"fade\" data-maxpages=\"0\" data-ajaxprebefore=\"\" data-ajaxbefore=\"\" data-ajaxafter=\"\" \/><input class=\"wpv_view_count wpv_view_count-2490\" type=\"hidden\" name=\"wpv_view_count\" value=\"2490\" \/>\n\n<div class=\"panel\">\n  <h2>Filter by<\/h2>\n <div class=\"form-group\">\n\t<label>Categories\n\t<select name=\"wpv-clinical-trial-category\" class=\"js-wpv-filter-trigger form-control\"><option selected='selected' value=\"0\">All Categories<\/option><option value=\"location\">Location<\/option><option value=\"pi\">PI<\/option><\/select><\/label>\n<\/div>\n<div class=\"form-group\">\n\t<label>Age Eligibility<br>\n\t<select name=\"wpv-age-requirement\" class=\"js-wpv-filter-trigger form-control\"><option selected='selected' value=\"0\">All Ages<\/option><option value=\"18-years-or-older\">18 Years or Older<\/option><option value=\"22-years-or-older\">22 Years or Older<\/option><option value=\"45-years-or-older\">45 Years or Older<\/option><option value=\"50-years-or-older\">50 Years or Older<\/option><option value=\"55-years-or-older\">55 Years or Older<\/option><option value=\"60-years-or-older\">60 Years or Older<\/option><option value=\"65-years-or-older\">65 Years or Older<\/option><option value=\"70-years-or-older\">70 Years or Older<\/option><option value=\"75-years-or-older\">75 Years or Older<\/option><\/select><\/label>\n<\/div>\n<div class=\"form-group\">\n\t<label for=\"wpv-diagnosed\">Diagnosis:<\/label>\n\t<div class=\"radio\">\n\t\t\t\t\t\t\t\t\t<label for=\"diagnosed-\"  class=\"\" >\n\t\t\t\t\t\t\t\t\t\t<input id=\"diagnosed-\"  class=\"js-wpv-filter-trigger\"\n\t\t\t\t\t\t\t\t\t\t\tname=\"wpv-diagnosed\" type=\"radio\" value=\"0\"  checked='checked'\n\t\t\t\t\t\t\t\t\t\t\/>\n\t\t\t\t\t\t\t\t\t\tAll Diagnosis\n\t\t\t\t\t\t\t\t\t<\/label>\n\t\t\t\t\t\t\t\t<\/div><div class=\"radio\"><label for=\"diagnosed-diabetes\"><input type=\"radio\" id=\"diagnosed-diabetes\" class=\"js-wpv-filter-trigger\" name=\"wpv-diagnosed\" value=\"diabetes\" \/>Diabetes<\/label><\/div><div class=\"radio\"><label for=\"diagnosed-heart-failure\"><input type=\"radio\" id=\"diagnosed-heart-failure\" class=\"js-wpv-filter-trigger\" name=\"wpv-diagnosed\" value=\"heart-failure\" \/>Heart Failure<\/label><\/div><div class=\"radio\"><label for=\"diagnosed-iga-nephropathy-igan\"><input type=\"radio\" id=\"diagnosed-iga-nephropathy-igan\" class=\"js-wpv-filter-trigger\" name=\"wpv-diagnosed\" value=\"iga-nephropathy-igan\" \/>IgA nephropathy (IgAN)<\/label><\/div><div class=\"radio\"><label for=\"diagnosed-kidney-disease\"><input type=\"radio\" id=\"diagnosed-kidney-disease\" class=\"js-wpv-filter-trigger\" name=\"wpv-diagnosed\" value=\"kidney-disease\" \/>Kidney Disease<\/label><\/div>\n<\/div>\n  \n  <ul class=\"inline loose-list-button\">\n    <li><input type=\"submit\" class=\"button wpv-submit-trigger js-wpv-submit-trigger\" name=\"wpv_filter_submit\" value=\"Submit\" \/><\/li>\n    <li><input type=\"button\" class=\"button wpv-reset-trigger js-wpv-reset-trigger\" name=\"wpv_filter_reset\" value=\"Reset\" \/><\/li>\n  <\/ul>\n<\/div>\n\n<\/form>\n\t<\/div>\n\t<div class=\"columns large-8 medium-8 small-12 pull-4\">\n      \t<div id=\"wpv-view-layout-2490\" class=\"js-wpv-view-layout js-wpv-layout-responsive js-wpv-view-layout-2490\" data-viewnumber=\"2490\" data-pagination=\"{&quot;id&quot;:&quot;2490&quot;,&quot;query&quot;:&quot;normal&quot;,&quot;type&quot;:&quot;disabled&quot;,&quot;effect&quot;:&quot;fade&quot;,&quot;duration&quot;:500,&quot;speed&quot;:5,&quot;pause_on_hover&quot;:&quot;disabled&quot;,&quot;stop_rollover&quot;:&quot;false&quot;,&quot;cache_pages&quot;:&quot;enabled&quot;,&quot;preload_images&quot;:&quot;enabled&quot;,&quot;preload_pages&quot;:&quot;enabled&quot;,&quot;preload_reach&quot;:1,&quot;spinner&quot;:&quot;builtin&quot;,&quot;spinner_image&quot;:&quot;https:\/\/lsom.uthscsa.edu\/nephrology\/wp-content\/plugins\/wp-views\/embedded\/res\/img\/ajax-loader.gif&quot;,&quot;callback_next&quot;:&quot;&quot;,&quot;manage_history&quot;:&quot;enabled&quot;,&quot;has_controls_in_form&quot;:&quot;disabled&quot;,&quot;infinite_tolerance&quot;:&quot;0&quot;,&quot;max_pages&quot;:0,&quot;page&quot;:1,&quot;base_permalink&quot;:&quot;\/nephrology\/wp-json\/wp\/v2\/pages\/2488?wpv_view_count=2490&amp;wpv_paged=WPV_PAGE_NUM&quot;,&quot;loop&quot;:{&quot;type&quot;:&quot;&quot;,&quot;name&quot;:&quot;&quot;,&quot;data&quot;:[],&quot;id&quot;:0}}\" data-permalink=\"\/nephrology\/wp-json\/wp\/v2\/pages\/2488?wpv_view_count=2490\">\n\n\t\n\t\n\t<ul class=\"loose-list line-delimited\">\n\t\t\n          <li>\n  <h2 class=\"close\"><a href=\"https:\/\/lsom.uthscsa.edu\/nephrology\/clinical-trial\/trident-transformative-research-in-diabetic-nephropathy\/\">TRIDENT &#8211; Transformative Research In Diabetic Nephropathy<\/a><\/h2>\n  <strong>Diagnosis Requirements: <\/strong>Type 1 or 2 Diabetes<br>\n  <strong>Age Eligibility: <\/strong>18 years and older<br>\n  <strong>Location: <\/strong>University Hospital and Texas Diabetes Institute<br>\n  <strong>P.I: <\/strong>Dr. Shweta Bansal; Sponsor: University of Pennsylvania<br><br>\n    <p>The purpose of this study is to gather a group of patients with diabetes who undergo a kidney biopsy to create a source of information with genetic, blood, and urine samples available, by which researchers can study how diabetes affects kidney function.<\/p>\n\n\n<\/li>\n\t\t\n          <li>\n  <h2 class=\"close\"><a href=\"https:\/\/lsom.uthscsa.edu\/nephrology\/clinical-trial\/spirrit-hfpef-pragmatic-trial\/\">SPIRRIT-HFpEF Pragmatic Trial<\/a><\/h2>\n  <strong>Diagnosis Requirements: <\/strong>Heart Failure with Preserved Ejection Fraction<br>\n  <strong>Age Eligibility: <\/strong>50 years and older<br>\n  <strong>Location: <\/strong>University Hospital and Texas Diabetes Institute<br>\n  <strong>P.I: <\/strong>Dr. Shweta Bansal; Sponsor: Duke Clinical Research Institute<br><br>\n    <p>The purpose of this study is to assess whether the initiation of spironolactone (which has shown to be effective for patients with heart failure with reduced ejection fraction) plus standard care improves outcomes compared to standard care alone in patients with Heart Failure with Preserved Ejection Fraction (HFpEF or stiff heart). It is a registry based randomized pragmatic clinical trial where patients do not need to come for separate study visits.<\/p>\n\n\n<\/li>\n\t\t\n          <li>\n  <h2 class=\"close\"><a href=\"https:\/\/lsom.uthscsa.edu\/nephrology\/clinical-trial\/nicotinamide-riboside-in-sars-cov-2-covid-19-patients-for-renal-protection-nirvana\/\">Nicotinamide Riboside in SARS-CoV-2 (COVID-19) Patients for Renal Protection (NIRVANA)<\/a><\/h2>\n  <strong>Diagnosis Requirements: <\/strong>SARS-CoV-2 Infection with Acute Kidney Injury<br>\n  <strong>Age Eligibility: <\/strong>18 years to 101 years<br>\n  <strong>Location: <\/strong>University Hospital<br>\n  <strong>P.I: <\/strong>Dr. Kumar Sharma; Sponsor: NIH-NIDDK<br><br>\n    \n\n<\/li>\n\t\t\n          <li>\n  <h2 class=\"close\"><a href=\"https:\/\/lsom.uthscsa.edu\/nephrology\/clinical-trial\/flow-clinical-trial\/\">FRONTIER Clinical Trial<\/a><\/h2>\n  <strong>Diagnosis Requirements: <\/strong>Type 2 diabetes with kidney disease<br>\n  <strong>Age Eligibility: <\/strong>18 years to 101 years<br>\n  <strong>Location: <\/strong>Texas Diabetes Institute<br>\n  <strong>P.I: <\/strong>Dr. Shweta Bansal; Sponsor: AstraZeneca<br><br>\n    <p>The FLOW clinical trial is phase 2 study evaluating the efficacy, safety and immunogenicity of new medication in adults with diabetic kidney disease who are already on standard of care therapy including angiotensin-converting enzyme (ACE) inhibitors or angiotensin receptor blockers (ARBs) and dapagliflozin, and still have protein in the urine. The total duration of study participation is 9 months.<\/p>\n\n\n<\/li>\n\t\t\n          <li>\n  <h2 class=\"close\"><a href=\"https:\/\/lsom.uthscsa.edu\/nephrology\/clinical-trial\/discover-ckd\/\">DISCOVER CKD<\/a><\/h2>\n  <strong>Diagnosis Requirements: <\/strong>Chronic Kidney Disease<br>\n  <strong>Age Eligibility: <\/strong>18 years and older<br>\n  <strong>Location: <\/strong>Texas Diabetes Institute<br>\n  <strong>P.I: <\/strong>Dr. Tareq Nassar; Sponsor: Astra Zeneca<br><br>\n    \n\n<\/li>\n\t\t\n          <li>\n  <h2 class=\"close\"><a href=\"https:\/\/lsom.uthscsa.edu\/nephrology\/clinical-trial\/applause-igan-clinical-trial\/\">APPLAUSE-IgAN Clinical Trial<\/a><\/h2>\n  <strong>Diagnosis Requirements: <\/strong>IgA nephropathy (IgAN)<br>\n  <strong>Age Eligibility: <\/strong>Age Eligibility: 18 years and older<br>\n  <strong>Location: <\/strong>Texas Diabetes Institute<br>\n  <strong>P.I: <\/strong>Dr. Shweta Bansal; Sponsor: Novartis Pharmaceuticals<br><br>\n    <p>Currently there are no evidence-based disease-modifying pharmacotherapies for IgAN. The purpose of this clinical trial is to evaluate the superiority of LNP023 (a factor B inhibitor which works by damping the innate immune system) versus placebo on top of the maximally tolerated doses of an ACEi or ARB in slowing kidney disease progression and reduction in the protein in the urine.<\/p>\n\n\n<\/li>\n\t\t\n          <li>\n  <h2 class=\"close\"><a href=\"https:\/\/lsom.uthscsa.edu\/nephrology\/clinical-trial\/void-hf-clinical-feasibility-research-trial\/\">(VOID-HF) \u2013 Clinical Feasibility Research Trial<\/a><\/h2>\n  <strong>Diagnosis Requirements: <\/strong>Decompensated Heart failure with persistent congestion<br>\n  <strong>Age Eligibility: <\/strong>Age Eligibility: 22 years and older<br>\n  <strong>Location: <\/strong>University Hospital and Texas Diabetes Institute<br>\n  <strong>P.I: <\/strong>Dr. Shweta Bansal; Sponsor: 3ive Labs, LLC<br><br>\n    <p>The purpose of this feasibility clinical research trial is to evaluate the safety and effectiveness of an investigational JuxtaFlow System performing negative pressure diuresis for the treatment of fluid overload and persistent congestion despite high dose intravenous diuretic therapy in patients with decompensated heart failure<\/p>\n\n\n<\/li>\n\t\t\n\t<\/ul>\n\t\n\t\n\t\n<\/div>\n \n    \t<ul class=\"pagination\">\n\t\t\t<li class=\"page-item\"><\/li>\n            \n\t\t\t<li class=\"page-item\"><\/li>\n\t\t<\/ul>\n\t<\/div>\n<\/div>[\/vc_column_text][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"Clinical trials, also known as research studies or patient studies, are essential in the fight against kidney diseases. These human studies help physician-scientists better understand, diagnose, treat and prevent diseases and conditions. UT Health San Antonio- Division of Nephrology conducts numerous clinical trials and research studies on a wide spectrum of kidney diseases including acute [...]","protected":false},"author":3,"featured_media":0,"parent":15,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-2488","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Clinical Trials - Nephrology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/lsom.uthscsa.edu\/nephrology\/research\/clinical-research-trials\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Clinical Trials - Nephrology\" \/>\n<meta property=\"og:url\" content=\"https:\/\/lsom.uthscsa.edu\/nephrology\/research\/clinical-research-trials\/\" \/>\n<meta property=\"og:site_name\" content=\"Nephrology\" \/>\n<meta property=\"article:modified_time\" content=\"2021-12-13T18:04:43+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/lsom.uthscsa.edu\\\/nephrology\\\/research\\\/clinical-research-trials\\\/\",\"url\":\"https:\\\/\\\/lsom.uthscsa.edu\\\/nephrology\\\/research\\\/clinical-research-trials\\\/\",\"name\":\"Clinical Trials - 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