{"id":3212,"date":"2023-02-06T13:10:45","date_gmt":"2023-02-06T19:10:45","guid":{"rendered":"https:\/\/lsom.uthscsa.edu\/neurology\/?page_id=3212"},"modified":"2025-04-02T16:56:38","modified_gmt":"2025-04-02T21:56:38","slug":"epilepsy-research","status":"publish","type":"page","link":"https:\/\/lsom.uthscsa.edu\/neurology\/epilepsy-research\/","title":{"rendered":"Epilepsy Research"},"content":{"rendered":"<div class=\"wpb-content-wrapper\" id=\"wpb-content-root\"><p>[vc_row][vc_column width=&#8221;2\/3&#8243;][vc_column_text css=&#8221;&#8221;]<\/p>\n<h1><b><span style=\"color: #993300\">Expertise:<\/span><\/b><\/h1>\n<p>Our research program offers clinical trials and innovative research for patients with medically refractory epilepsies.[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column width=&#8221;5\/6&#8243;]<ul class=\"accordion accordion-block-type\" data-accordion data-allow-all-closed=\"true\"><li class=\"accordion-item is-active\" data-accordion-item><a href=\"#\" class=\"accordion-title\"><h2>EpiNet<\/h2><\/a><div class=\"accordion-content\" data-tab-content><p><p style=\"text-align: left\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-2255 alignleft\" src=\"https:\/\/lsom.uthscsa.edu\/neurology\/wp-content\/uploads\/sites\/105\/2021\/07\/562fe1307010539805350952.jpg\" alt=\"\" width=\"84\" height=\"117\" \/> \u00a0<em><strong>Principal Investigator:<\/strong><\/em><br \/>Diep Bui, MD<\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/clinicaltrials.gov\/study\/NCT01662453?cond=SUDEP&amp;rank=3\">https:\/\/clinicaltrials.gov\/study\/NCT01662453?cond=SUDEP&amp;rank=3<\/a><\/p>\n<p><strong>Type of Study:<\/strong><br \/>Registry\/ Observational<\/p>\n<p><strong>Summary<\/strong><br \/>This study aims to develop a North American registry for SUDEP cases; requesting family members of epilepsy patients who died suddenly of unclear causes (SUDEP) to contact the study team. The family members who decide to participate in the study will be asked to complete a brief telephone interview about their loved one&#8217;s epilepsy and seizure history and the circumstances of his or her death. If the death has occurred within the past 24 hours, and the family is willing to consider donating tissue to the study, the subject will be transferred to the Autism Tissue Program, and the remainder of the phone interview will be conducted at a later time. One of the main objectives of this study is to investigate the role of various risk factors in the development of sudden unexplained death in patients with epilepsy, with a particular focus on the role of antiepileptic medications. In addition, we want to elucidate the pathophysiologic mechanisms leading to SUDEP<\/p>\n<p><strong>Link to Sponsor&#8217;s Website:<br \/><\/strong><a href=\"https:\/\/www.epinet.co.nz\/current-studies\/\">https:\/\/www.epinet.co.nz\/current-studies\/<\/a><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignright wp-image-4271\" src=\"https:\/\/lsom.uthscsa.edu\/neurology\/wp-content\/uploads\/sites\/105\/2024\/08\/1C9_3F_13070105_781837027_2.jpg\" alt=\"\" width=\"84\" height=\"117\" \/><\/p>\n<p style=\"text-align: right\"><em><strong>Study Coordinator:<\/strong><\/em><br \/>Anthony Torres<br \/>Office: 210-450-8455<br \/>Email:\u00a0<a href=\"mailto:torresa23@uthscsa.edu\">torresa23@uthscsa.edu<\/a><\/p><\/div><\/li><li class=\"accordion-item \" data-accordion-item><a href=\"#\" class=\"accordion-title\"><h2>Retrospect EMU Study<\/h2><\/a><div class=\"accordion-content\" data-tab-content><p><p style=\"text-align: left\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-1215\" src=\"https:\/\/lsom.uthscsa.edu\/neurology\/wp-content\/uploads\/sites\/105\/2019\/08\/Charles-Szabo-2-322x450.jpg\" alt=\"\" width=\"84\" height=\"117\" srcset=\"https:\/\/lsom.uthscsa.edu\/neurology\/wp-content\/uploads\/sites\/105\/2019\/08\/Charles-Szabo-2-322x450.jpg 322w, https:\/\/lsom.uthscsa.edu\/neurology\/wp-content\/uploads\/sites\/105\/2019\/08\/Charles-Szabo-2.jpg 429w\" sizes=\"auto, (max-width: 84px) 100vw, 84px\" \/> \u00a0<em><strong>Principal Investigator:<\/strong><\/em><br \/>Charles Szabo, MD<\/p>\n<p>&nbsp;<\/p>\n<p><strong>Type of Study:<\/strong><br \/>Registry\/ Observational<\/p>\n<p><strong>Summary<\/strong><br \/>This study aims to retrospectively compare cases of SUDEP with matched control subjects cared for by the same epilepsy center to identify risk factors and potential biomarkers associated with SUDEP.<\/p>\n<p style=\"text-align: right\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-4271 alignright\" src=\"https:\/\/lsom.uthscsa.edu\/neurology\/wp-content\/uploads\/sites\/105\/2024\/08\/1C9_3F_13070105_781837027_2.jpg\" alt=\"\" width=\"84\" height=\"117\" \/><\/p>\n<p style=\"text-align: right\"><em><strong>Study Coordinator:<\/strong><\/em><br \/>Anthony Torres<br \/>Office: 210-450-8455<br \/>Email:\u00a0<a href=\"mailto:torresa23@uthscsa.edu\">torresa23@uthscsa.edu<\/a><\/p>\n<p>&nbsp;<\/p><\/div><\/li><li class=\"accordion-item \" data-accordion-item><a href=\"#\" class=\"accordion-title\"><h2>Epitel (REMI)<\/h2><\/a><div class=\"accordion-content\" data-tab-content><p><p style=\"text-align: left\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-2091 alignleft\" src=\"https:\/\/lsom.uthscsa.edu\/neurology\/wp-content\/uploads\/sites\/105\/2020\/11\/kameel-karkar-286x400.jpg\" alt=\"\" width=\"84\" height=\"117\" srcset=\"https:\/\/lsom.uthscsa.edu\/neurology\/wp-content\/uploads\/sites\/105\/2020\/11\/kameel-karkar-286x400.jpg 286w, https:\/\/lsom.uthscsa.edu\/neurology\/wp-content\/uploads\/sites\/105\/2020\/11\/kameel-karkar-393x550.jpg 393w, https:\/\/lsom.uthscsa.edu\/neurology\/wp-content\/uploads\/sites\/105\/2020\/11\/kameel-karkar.jpg 429w\" sizes=\"auto, (max-width: 84px) 100vw, 84px\" \/> \u00a0<em><strong>Principal Investigator:<\/strong><\/em><br \/>Kameel Karkar, MD<\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/clinicaltrials.gov\/study\/NCT06027749\">https:\/\/clinicaltrials.gov\/study\/NCT06027749<\/a><\/p>\n<p><strong>Type of Study:<\/strong><br \/>Interventional<\/p>\n<p><strong>Summary<\/strong><br \/>The goal of this clinical trial is to test Epitel&#8217;s\u2122 Remote EEG Monitoring System&#8217;s (REMI\u2122) ability to record electroencephalography (EEG) of seizure events in an ambulatory setting for extended periods (14 &#8211; 28 days) in patients presenting with questionable seizure characterization. The main questions it aims to answer are: Can more seizure events be recorded in fourteen (14) days than can be recorded in three (3) days? Do treating clinicians find clinical value in extended fourteen (14) &#8211; twenty-eight (28) days of EEG? Participants will wear a portable EEG device (REMI) for fourteen (14) to twenty-eight (28) days in their home\/community setting<\/p>\n<p>The purpose of this study is to demonstrate that the REMI system is able to record EEG data that clinicians can use to identify ictal events over extended periods, and that extended clinical EEG data is valuable in the diagnosis and treatment of seizure related symptoms<\/p>\n<p><strong>Link to Sponsor&#8217;s Website:<br \/><\/strong><a href=\"https:\/\/www.epitel.com\/about-epitel\">https:\/\/www.epitel.com\/about-epitel<\/a><\/p>\n<p style=\"text-align: right\"><em><strong><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-4271 alignright\" src=\"https:\/\/lsom.uthscsa.edu\/neurology\/wp-content\/uploads\/sites\/105\/2024\/08\/1C9_3F_13070105_781837027_2.jpg\" alt=\"\" width=\"84\" height=\"117\" \/><\/strong><\/em><\/p>\n<p style=\"text-align: right\"><em><strong>Study Coordinator:<\/strong><\/em><br \/>Anthony Torres<br \/>Office: 210-450-8455<br \/>Email:\u00a0<a href=\"mailto:torresa23@uthscsa.edu\">torresa23@uthscsa.edu<\/a><\/p>\n<p>&nbsp;<\/p><\/div><\/li><li class=\"accordion-item \" data-accordion-item><a href=\"#\" class=\"accordion-title\"><h2>XPF-010-301 (X-TOLE2)<\/h2><\/a><div class=\"accordion-content\" data-tab-content><p><p style=\"text-align: left\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-1215\" src=\"https:\/\/lsom.uthscsa.edu\/neurology\/wp-content\/uploads\/sites\/105\/2019\/08\/Charles-Szabo-2-322x450.jpg\" alt=\"\" width=\"84\" height=\"117\" srcset=\"https:\/\/lsom.uthscsa.edu\/neurology\/wp-content\/uploads\/sites\/105\/2019\/08\/Charles-Szabo-2-322x450.jpg 322w, https:\/\/lsom.uthscsa.edu\/neurology\/wp-content\/uploads\/sites\/105\/2019\/08\/Charles-Szabo-2.jpg 429w\" sizes=\"auto, (max-width: 84px) 100vw, 84px\" \/> \u00a0<em><strong>Principal Investigator:<\/strong><\/em><br \/>Charles Szabo, MD<\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/clinicaltrials.gov\/study\/NCT05614063\">https:\/\/clinicaltrials.gov\/study\/NCT05614063<\/a><\/p>\n<p><strong>Type of Study:<\/strong><br \/>Interventional\/Randomized Control<\/p>\n<p><strong>Summary:<\/strong><br \/>The X-TOLE2 Phase 3 clinical trial is a randomized, double-blind, placebo-controlled study that will evaluate the clinical efficacy, safety and tolerability of XEN1101 administered as adjunctive therapy in focal-onset seizures<\/p>\n<p><strong>Link to Sponsor&#8217;s Website:<br \/><\/strong><a href=\"https:\/\/www.xenon-pharma.com\/about\/\">https:\/\/www.xenon-pharma.com\/about\/<\/a><strong><br \/><\/strong><\/p>\n<p style=\"text-align: right\"><em><strong><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-4271 alignright\" src=\"https:\/\/lsom.uthscsa.edu\/neurology\/wp-content\/uploads\/sites\/105\/2024\/08\/1C9_3F_13070105_781837027_2.jpg\" alt=\"\" width=\"84\" height=\"117\" \/><\/strong><\/em><\/p>\n<p style=\"text-align: right\"><em><strong>Study Coordinator:<\/strong><\/em><br \/>Anthony Torres<br \/>Office: 210-450-8455<br \/>Email:\u00a0<a href=\"mailto:torresa23@uthscsa.edu\">torresa23@uthscsa.edu<\/a><\/p>\n<p>&nbsp;<\/p><\/div><\/li><li class=\"accordion-item \" data-accordion-item><a href=\"#\" class=\"accordion-title\"><h2>XPF-010-303 (X-ACKT)<\/h2><\/a><div class=\"accordion-content\" data-tab-content><p><p style=\"text-align: left\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-1215\" src=\"https:\/\/lsom.uthscsa.edu\/neurology\/wp-content\/uploads\/sites\/105\/2019\/08\/Charles-Szabo-2-322x450.jpg\" alt=\"\" width=\"84\" height=\"117\" srcset=\"https:\/\/lsom.uthscsa.edu\/neurology\/wp-content\/uploads\/sites\/105\/2019\/08\/Charles-Szabo-2-322x450.jpg 322w, https:\/\/lsom.uthscsa.edu\/neurology\/wp-content\/uploads\/sites\/105\/2019\/08\/Charles-Szabo-2.jpg 429w\" sizes=\"auto, (max-width: 84px) 100vw, 84px\" \/> \u00a0<em><strong>Principal Investigator:<\/strong><\/em><br \/>Charles Szabo, MD<\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/clinicaltrials.gov\/study\/NCT05667142\">https:\/\/clinicaltrials.gov\/study\/NCT05667142<\/a><\/p>\n<p><strong>Type of Study:<\/strong><br \/>Interventional\/Randomized Control<\/p>\n<p><strong>Summary:<\/strong><br \/>This is a Phase 3, multicenter, randomized, double-blind, placebo-controlled study to evaluate the clinical efficacy, safety, and tolerability of XEN1101 administered as adjunctive treatment in primary generalized tonic-clonic seizures (PGTCS)<\/p>\n<p><strong>Link to Sponsor&#8217;s Website:<br \/><\/strong><a href=\"https:\/\/www.xenon-pharma.com\/about\/\">https:\/\/www.xenon-pharma.com\/about\/<\/a><\/p>\n<p style=\"text-align: right\"><em><strong><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-4271 alignright\" src=\"https:\/\/lsom.uthscsa.edu\/neurology\/wp-content\/uploads\/sites\/105\/2024\/08\/1C9_3F_13070105_781837027_2.jpg\" alt=\"\" width=\"84\" height=\"117\" \/><\/strong><\/em><\/p>\n<p style=\"text-align: right\"><em><strong>Study Coordinator:<\/strong><\/em><br \/>Anthony Torres<br \/>Office: 210-450-8455<br \/>Email:\u00a0<a href=\"mailto:torresa23@uthscsa.edu\">torresa23@uthscsa.edu<\/a><\/p>\n<p>&nbsp;<\/p><\/div><\/li><li class=\"accordion-item \" data-accordion-item><a href=\"#\" class=\"accordion-title\"><h2>EPICOM<\/h2><\/a><div class=\"accordion-content\" data-tab-content><p><p style=\"text-align: left\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-1430\" src=\"https:\/\/lsom.uthscsa.edu\/neurology\/wp-content\/uploads\/sites\/105\/2019\/08\/leary_linda.jpg\" alt=\"\" width=\"84\" height=\"117\" \/> \u00a0<em><strong>Principal Investigator:<\/strong><\/em><br \/>Linda Leary, MD<\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/clinicaltrials.gov\/study\/NCT05864846\">https:\/\/clinicaltrials.gov\/study\/NCT05864846<\/a><\/p>\n<p><strong>Type of Study:<\/strong><br \/>Interventional\/Open Label<\/p>\n<p><strong>Summary:<\/strong><br \/>The purpose of this study is to investigate behavioral and other co-occurring outcomes with EPID(I\/Y)OLEX as an add-on therapy in participants aged 1 to 65 years with tuberous sclerosis complex (TSC) who experience seizures.<\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: right\"><em><strong><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-4271 alignright\" src=\"https:\/\/lsom.uthscsa.edu\/neurology\/wp-content\/uploads\/sites\/105\/2024\/08\/1C9_3F_13070105_781837027_2.jpg\" alt=\"\" width=\"84\" height=\"117\" \/><\/strong><\/em><\/p>\n<p style=\"text-align: right\"><em><strong>Study Coordinator:<\/strong><\/em><br \/>Anthony Torres<br \/>Office: 210-450-8455<br \/>Email:\u00a0<a href=\"mailto:torresa23@uthscsa.edu\">torresa23@uthscsa.edu<\/a><\/p>\n<p>&nbsp;<\/p><\/div><\/li><li class=\"accordion-item \" data-accordion-item><a href=\"#\" class=\"accordion-title\"><h2>BHV7000-302 (RISE 2)<\/h2><\/a><div class=\"accordion-content\" data-tab-content><p><p style=\"text-align: left\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-2097 alignleft\" src=\"https:\/\/lsom.uthscsa.edu\/neurology\/wp-content\/uploads\/sites\/105\/2020\/11\/octavianlie-286x400.jpg\" alt=\"\" width=\"84\" height=\"117\" srcset=\"https:\/\/lsom.uthscsa.edu\/neurology\/wp-content\/uploads\/sites\/105\/2020\/11\/octavianlie-286x400.jpg 286w, https:\/\/lsom.uthscsa.edu\/neurology\/wp-content\/uploads\/sites\/105\/2020\/11\/octavianlie-393x550.jpg 393w, https:\/\/lsom.uthscsa.edu\/neurology\/wp-content\/uploads\/sites\/105\/2020\/11\/octavianlie.jpg 429w\" sizes=\"auto, (max-width: 84px) 100vw, 84px\" \/> \u00a0<em><strong>Principal Investigator:<\/strong><\/em><br \/>Octavian Lie, MD<\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/clinicaltrials.gov\/study\/NCT06132893\">https:\/\/clinicaltrials.gov\/study\/NCT06132893<\/a><\/p>\n<p><strong>Type of Study:<\/strong><br \/>Interventional\/Randomized Control<\/p>\n<p><strong>Summary:<\/strong><br \/>The purpose of this study is to determine whether BHV-7000 is effective in the treatment of refractory focal epilepsy<\/p>\n<p><strong>Link to Sponsor&#8217;s Website:<br \/><\/strong><a href=\"https:\/\/www.biohavenclinicaltrials.com\/find-a-trial\/?searchKeyword=focal%20epilepsy\">https:\/\/www.biohavenclinicaltrials.com\/find-a-trial\/?searchKeyword=focal%20epilepsy<\/a><\/p>\n<p style=\"text-align: right\"><em><strong><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-4271 alignright\" src=\"https:\/\/lsom.uthscsa.edu\/neurology\/wp-content\/uploads\/sites\/105\/2024\/08\/1C9_3F_13070105_781837027_2.jpg\" alt=\"\" width=\"84\" height=\"117\" \/><\/strong><\/em><\/p>\n<p style=\"text-align: right\"><em><strong>Study Coordinator:<\/strong><\/em><br \/>Anthony Torres<br \/>Office: 210-450-8455<br \/>Email:\u00a0<a href=\"mailto:torresa23@uthscsa.edu\">torresa23@uthscsa.edu<\/a><\/p>\n<p>&nbsp;<\/p><\/div><\/li><\/ul>[\/vc_column][vc_column width=&#8221;1\/6&#8243;][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column width=&#8221;2\/3&#8243;][vc_column_text css=&#8221;&#8221;] Expertise: Our research program offers clinical trials and innovative research for patients with medically refractory epilepsies.[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column width=&#8221;5\/6&#8243;][\/vc_column][vc_column width=&#8221;1\/6&#8243;][\/vc_column][\/vc_row]<\/p>\n","protected":false},"author":226,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-3212","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Epilepsy 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