{"id":4915,"date":"2025-04-01T16:20:43","date_gmt":"2025-04-01T21:20:43","guid":{"rendered":"https:\/\/lsom.uthscsa.edu\/neurology\/?page_id=4915"},"modified":"2025-07-14T09:12:05","modified_gmt":"2025-07-14T14:12:05","slug":"movement-research","status":"publish","type":"page","link":"https:\/\/lsom.uthscsa.edu\/neurology\/movement-research\/","title":{"rendered":"Movement Research"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row][vc_column width=&#8221;2\/3&#8243;][vc_column_text css=&#8221;&#8221;]<\/p>\n<h1><b><span style=\"color: #993300\">Expertise:<\/span><\/b><\/h1>\n<p>We offer a robust research program including many Clinical trials and innovative research for patients with Parkinson\u2019s Disease and other movement disorders.[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column width=&#8221;5\/6&#8243;]<ul class=\"accordion accordion-block-type\" data-accordion data-allow-all-closed=\"true\"><li class=\"accordion-item is-active\" data-accordion-item><a href=\"#\" class=\"accordion-title\"><h2>CAMELOT<\/h2><\/a><div class=\"accordion-content\" data-tab-content><p><p style=\"text-align: left\"><em><strong><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-1702\" src=\"https:\/\/lsom.uthscsa.edu\/neurology\/wp-content\/uploads\/sites\/105\/2019\/11\/Sarah-Horn-321x450.jpg\" alt=\"\" width=\"104\" height=\"146\" srcset=\"https:\/\/lsom.uthscsa.edu\/neurology\/wp-content\/uploads\/sites\/105\/2019\/11\/Sarah-Horn-321x450.jpg 321w, https:\/\/lsom.uthscsa.edu\/neurology\/wp-content\/uploads\/sites\/105\/2019\/11\/Sarah-Horn-768x1075.jpg 768w, https:\/\/lsom.uthscsa.edu\/neurology\/wp-content\/uploads\/sites\/105\/2019\/11\/Sarah-Horn-464x650.jpg 464w, https:\/\/lsom.uthscsa.edu\/neurology\/wp-content\/uploads\/sites\/105\/2019\/11\/Sarah-Horn-640x896.jpg 640w, https:\/\/lsom.uthscsa.edu\/neurology\/wp-content\/uploads\/sites\/105\/2019\/11\/Sarah-Horn-1024x1433.jpg 1024w, https:\/\/lsom.uthscsa.edu\/neurology\/wp-content\/uploads\/sites\/105\/2019\/11\/Sarah-Horn-1200x1680.jpg 1200w, https:\/\/lsom.uthscsa.edu\/neurology\/wp-content\/uploads\/sites\/105\/2019\/11\/Sarah-Horn-1920x2688.jpg 1920w\" sizes=\"auto, (max-width: 104px) 100vw, 104px\" \/><\/strong><\/em><\/p>\n<p style=\"text-align: left\"><em><strong>Principal Investigator:<\/strong><\/em><br \/>Sarah Horn, MD<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/clinicaltrials.gov\/study\/NCT05590637\">https:\/\/clinicaltrials.gov\/study\/NCT05590637<\/a><\/p>\n<p><strong>Type of Study:<\/strong><br \/>Interventional\/Randomized Control<\/p>\n<p><strong>Summary<\/strong><br \/>The primary objective of this study is to determine whether treatment with pimavanserin or quetiapine is associated with a greater improvement in psychosis when used in a routine clinical setting to treat hallucinations and\/or delusions due to Parkinson&#8217;s disease (PD) or dementia with Lewy bodies (DLB) &#8211; collectively referred to as Lewy body disease (LBD).<\/p>\n<p>&nbsp;<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignright wp-image-1479\" src=\"https:\/\/lsom.uthscsa.edu\/neurology\/wp-content\/uploads\/sites\/105\/2019\/09\/Carolyn-Paiz_008-321x450.jpg\" alt=\"\" width=\"104\" height=\"146\" srcset=\"https:\/\/lsom.uthscsa.edu\/neurology\/wp-content\/uploads\/sites\/105\/2019\/09\/Carolyn-Paiz_008-321x450.jpg 321w, https:\/\/lsom.uthscsa.edu\/neurology\/wp-content\/uploads\/sites\/105\/2019\/09\/Carolyn-Paiz_008.jpg 428w\" sizes=\"auto, (max-width: 104px) 100vw, 104px\" \/><\/p>\n<p style=\"text-align: right\"><em><strong>Study Coordinator:<\/strong><\/em><br \/>Carolyn Paiz<br \/>Office: 210-450-8830<br \/>Email:\u00a0<a href=\"mailto:paizc@uthscsa.edu\">paizc@uthscsa.edu<\/a><\/p><\/div><\/li><li class=\"accordion-item \" data-accordion-item><a href=\"#\" class=\"accordion-title\"><h2>PD GENEration<\/h2><\/a><div class=\"accordion-content\" data-tab-content><p><p style=\"text-align: left\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-2980\" src=\"https:\/\/lsom.uthscsa.edu\/neurology\/wp-content\/uploads\/sites\/105\/2022\/11\/13f1ce1307010511837880632.jpg\" alt=\"\" width=\"104\" height=\"145\" \/> \u00a0<em><strong>Principal Investigator:<\/strong><\/em><br \/>Okeanis Vaou, MD<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/clinicaltrials.gov\/study\/NCT04994015\">https:\/\/clinicaltrials.gov\/study\/NCT04994015<\/a><\/p>\n<p><strong>Type of Study:<\/strong><br \/>Registry\/ Observational<\/p>\n<p><strong>Summary<\/strong><br \/>The purpose of this study is to develop a central repository for PD-related genomic data by individuals who consent to deposit their data and bank their residual DNA obtained through clinical genetic testing for future research use.<\/p>\n<p><strong>Link to Sponsor&#8217;s Website:<br \/><\/strong><a href=\"https:\/\/www.parkinson.org\/advancing-research\/our-research\/pdgeneration\">https:\/\/www.parkinson.org\/advancing-research\/our-research\/pdgeneration<\/a><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignright wp-image-5428\" src=\"https:\/\/lsom.uthscsa.edu\/neurology\/wp-content\/uploads\/sites\/105\/2025\/06\/Victoria-Carranza-1-286x400.jpg\" alt=\"\" width=\"104\" height=\"145\" srcset=\"https:\/\/lsom.uthscsa.edu\/neurology\/wp-content\/uploads\/sites\/105\/2025\/06\/Victoria-Carranza-1-286x400.jpg 286w, https:\/\/lsom.uthscsa.edu\/neurology\/wp-content\/uploads\/sites\/105\/2025\/06\/Victoria-Carranza-1-393x550.jpg 393w, https:\/\/lsom.uthscsa.edu\/neurology\/wp-content\/uploads\/sites\/105\/2025\/06\/Victoria-Carranza-1.jpg 429w\" sizes=\"auto, (max-width: 104px) 100vw, 104px\" \/><\/p>\n<p style=\"text-align: right\"><em><strong>Study Coordinator:<\/strong><\/em><br \/>Victoria Carranza<br \/>Office: 210-450-8907<br \/>Email:\u00a0<a href=\"mailto:carranzav@uthscsa.edu\">carranzav@uthscsa.edu<\/a><\/p><\/div><\/li><li class=\"accordion-item \" data-accordion-item><a href=\"#\" class=\"accordion-title\"><h2>EXERCISE AND GAMING<\/h2><\/a><div class=\"accordion-content\" data-tab-content><p><p style=\"text-align: left\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-4921 alignleft\" src=\"https:\/\/lsom.uthscsa.edu\/neurology\/wp-content\/uploads\/sites\/105\/2025\/04\/35E_2C3_13070105_573633874_2.jpg\" alt=\"\" width=\"104\" height=\"145\" \/> <em><strong>Principal Investigator:<\/strong><\/em><br \/>Anjali Sivaramakrishnan<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/clinicaltrials.gov\/study\/NCT06133283\">https:\/\/clinicaltrials.gov\/study\/NCT06133283<\/a><\/p>\n<p><strong>Type of Study:<\/strong><br \/>Interventional<\/p>\n<p><strong>Summary<\/strong><br \/>This study aims to determine the effects of aerobic exercise as a primer to add-on virtual reality (VR)-based rehabilitation on balance, postural control and neuroplasticity (ability of brain to adapt in structure and function) in individuals with Parkinson&#8217;s disease (PD). This study will utilize two groups &#8211; one group will receive the exercise and VR, while the other group will receive stretching exercise and VR over eight weeks. The study team will administer outcomes at baseline, post-intervention (8 weeks) and follow-up (6 weeks after post-assessment)<\/p>\n<p>&nbsp;<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-1479 alignright\" src=\"https:\/\/lsom.uthscsa.edu\/neurology\/wp-content\/uploads\/sites\/105\/2019\/09\/Carolyn-Paiz_008-321x450.jpg\" alt=\"\" width=\"104\" height=\"146\" srcset=\"https:\/\/lsom.uthscsa.edu\/neurology\/wp-content\/uploads\/sites\/105\/2019\/09\/Carolyn-Paiz_008-321x450.jpg 321w, https:\/\/lsom.uthscsa.edu\/neurology\/wp-content\/uploads\/sites\/105\/2019\/09\/Carolyn-Paiz_008.jpg 428w\" sizes=\"auto, (max-width: 104px) 100vw, 104px\" \/><\/p>\n<p style=\"text-align: right\"><em><strong>Study Coordinator:<\/strong><\/em><br \/>Carolyn Paiz<br \/>Office: 210-450-8830<br \/>Email:\u00a0<a href=\"mailto:paizc@uthscsa.edu\">paizc@uthscsa.edu<\/a><\/p><\/div><\/li><li class=\"accordion-item \" data-accordion-item><a href=\"#\" class=\"accordion-title\"><h2>VERCISE-A4069<\/h2><\/a><div class=\"accordion-content\" data-tab-content><p><p style=\"text-align: left\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-2980\" src=\"https:\/\/lsom.uthscsa.edu\/neurology\/wp-content\/uploads\/sites\/105\/2022\/11\/13f1ce1307010511837880632.jpg\" alt=\"\" width=\"104\" height=\"145\" \/> \u00a0<em><strong>Principal Investigator:<\/strong><\/em><br \/>Okeanis Vaou, MD<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/clinicaltrials.gov\/study\/NCT02071134\">https:\/\/clinicaltrials.gov\/study\/NCT02071134<\/a><\/p>\n<p><strong>Type of Study:<\/strong><br \/>Registry\/ Observational<\/p>\n<p><strong>Summary<\/strong><br \/>The purpose of this registry is to compile characteristics of world-wide outcomes for the use of Boston Scientific&#8217;s commercially available Vercise DBS system in the treatment of Parkinson&#8217;s disease. \u00a0Subjects&#8217; improvement in disease symptoms and overall Quality of life will be assessed during the study following DBS and compared with baseline. Additionally, the utilization of Image Guided Programming (IGP) when used as a planning tool for programming of patients is also evaluated<\/p>\n<p><strong>Link to Sponsor&#8217;s Website:<br \/><\/strong><a href=\"https:\/\/www.bostonscientific.com\/en-US\/search.html#q=vercise%20trial&amp;first=10\">https:\/\/www.bostonscientific.com\/en-US\/search.html#q=vercise%20trial&amp;first=10<\/a><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignright wp-image-1479\" src=\"https:\/\/lsom.uthscsa.edu\/neurology\/wp-content\/uploads\/sites\/105\/2019\/09\/Carolyn-Paiz_008-321x450.jpg\" alt=\"\" width=\"104\" height=\"146\" srcset=\"https:\/\/lsom.uthscsa.edu\/neurology\/wp-content\/uploads\/sites\/105\/2019\/09\/Carolyn-Paiz_008-321x450.jpg 321w, https:\/\/lsom.uthscsa.edu\/neurology\/wp-content\/uploads\/sites\/105\/2019\/09\/Carolyn-Paiz_008.jpg 428w\" sizes=\"auto, (max-width: 104px) 100vw, 104px\" \/><\/p>\n<p style=\"text-align: right\"><em><strong>Study Coordinator:<\/strong><\/em><br \/>Carolyn Paiz<br \/>Office: 210-450-8830<br \/>Email:\u00a0<a href=\"mailto:paizc@uthscsa.edu\">paizc@uthscsa.edu<\/a><\/p><\/div><\/li><li class=\"accordion-item \" data-accordion-item><a href=\"#\" class=\"accordion-title\"><h2>ROSSINI<\/h2><\/a><div class=\"accordion-content\" data-tab-content><p><p style=\"text-align: left\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-2980\" src=\"https:\/\/lsom.uthscsa.edu\/neurology\/wp-content\/uploads\/sites\/105\/2022\/11\/13f1ce1307010511837880632.jpg\" alt=\"\" width=\"104\" height=\"145\" \/> \u00a0<em><strong>Principal Investigator:<\/strong><\/em><br \/>Okeanis Vaou, MD<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/clinicaltrials.gov\/study\/NCT06107426\">https:\/\/clinicaltrials.gov\/study\/NCT06107426<\/a><\/p>\n<p><strong>Type of Study:<\/strong><br \/>Observational<\/p>\n<p><strong>Summary<\/strong><br \/>Parkinson&#8217;s disease (PD) is a neurological condition, which affects the brain. <br \/>PD gets worse over time, but how quickly it progresses varies a lot from person to person. Some symptoms of PD are tremors, stiffness, and slowness of movement. The purpose of this study is to evaluate how effective ABBV-951 is in treating adult participants with advanced PD in real world setting.<\/p>\n<p>&nbsp;<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignright wp-image-1479\" src=\"https:\/\/lsom.uthscsa.edu\/neurology\/wp-content\/uploads\/sites\/105\/2019\/09\/Carolyn-Paiz_008-321x450.jpg\" alt=\"\" width=\"104\" height=\"146\" srcset=\"https:\/\/lsom.uthscsa.edu\/neurology\/wp-content\/uploads\/sites\/105\/2019\/09\/Carolyn-Paiz_008-321x450.jpg 321w, https:\/\/lsom.uthscsa.edu\/neurology\/wp-content\/uploads\/sites\/105\/2019\/09\/Carolyn-Paiz_008.jpg 428w\" sizes=\"auto, (max-width: 104px) 100vw, 104px\" \/><\/p>\n<p style=\"text-align: right\"><em><strong>Study Coordinator:<\/strong><\/em><br \/>Carolyn Paiz<br \/>Office: 210-450-8830<br \/>Email:\u00a0<a href=\"mailto:paizc@uthscsa.edu\">paizc@uthscsa.edu<\/a><\/p><\/div><\/li><li class=\"accordion-item \" data-accordion-item><a href=\"#\" class=\"accordion-title\"><h2>SPARX3<\/h2><\/a><div class=\"accordion-content\" data-tab-content><p><p style=\"text-align: left\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-2980\" src=\"https:\/\/lsom.uthscsa.edu\/neurology\/wp-content\/uploads\/sites\/105\/2022\/11\/13f1ce1307010511837880632.jpg\" alt=\"\" width=\"104\" height=\"145\" \/> \u00a0<em><strong>Principal Investigator:<\/strong><\/em><br \/>Okeanis Vaou, MD<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/clinicaltrials.gov\/study\/NCT04284436\">https:\/\/clinicaltrials.gov\/study\/NCT04284436<\/a><\/p>\n<p><strong>Type of Study:<\/strong><br \/>Interventional\/Randomized Control<\/p>\n<p><strong>Summary<\/strong><br \/>This study is a Phase 3 multi-site, randomized, evaluator-masked, study of endurance treadmill exercise on changes in the Movement Disorder Society-Unified Parkinson Disease Rating Scale (MDS-UPDRS) Part III score at 12 months among persons with early stage Parkinson disease. 370 participants will be randomly assigned to 2 groups: 1)60-65% HRmax or 2)80-85% HRmax 4 times per week. The primary objective is to test whether the progression of the signs of Parkinson&#8217;s disease is attenuated at 12 months in among persons who have not initiated medication for Parkinson Disease (PD) when they perform high-intensity endurance treadmill exercise.<\/p>\n<p><strong>Link to Sponsor&#8217;s Website:<br \/><\/strong><a href=\"https:\/\/www.sparx3pd.com\/home\/volunteer\">https:\/\/www.sparx3pd.com\/home\/volunteer<\/a><\/p>\n<p>&nbsp;<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignright wp-image-1479\" src=\"https:\/\/lsom.uthscsa.edu\/neurology\/wp-content\/uploads\/sites\/105\/2019\/09\/Carolyn-Paiz_008-321x450.jpg\" alt=\"\" width=\"104\" height=\"146\" srcset=\"https:\/\/lsom.uthscsa.edu\/neurology\/wp-content\/uploads\/sites\/105\/2019\/09\/Carolyn-Paiz_008-321x450.jpg 321w, https:\/\/lsom.uthscsa.edu\/neurology\/wp-content\/uploads\/sites\/105\/2019\/09\/Carolyn-Paiz_008.jpg 428w\" sizes=\"auto, (max-width: 104px) 100vw, 104px\" \/><\/p>\n<p style=\"text-align: right\"><em><strong>Study Coordinator:<\/strong><\/em><br \/>Carolyn Paiz<br \/>Office: 210-450-8830<br \/>Email:\u00a0<a href=\"mailto:paizc@uthscsa.edu\">paizc@uthscsa.edu<\/a><\/p><\/div><\/li><\/ul>[\/vc_column][vc_column width=&#8221;1\/6&#8243;] \n        <a class=\"panel no-equilizer panel-mobile text-center colorized colorized-patientcare\" href=\"\" title=\"\" target=\"\">\n            <span class=\"circle close2x mid-icon\"><span><i class=\"icon-book\"><\/i><\/span><\/span><br>\n            <h3 >Parkinson Study Group - Clinical Trial Updates<\/h3>\n            <p><\/p>\n        <\/a> \n        <a class=\"panel no-equilizer panel-mobile text-center colorized colorized-patientcare\" href=\"\" title=\"\" target=\"\">\n            <span class=\"circle close2x mid-icon\"><span><i class=\"vc-oi vc-oi-attach\"><\/i><\/span><\/span><br>\n            <h3 >Parkinsons Foundation - Our Research<\/h3>\n            <p><\/p>\n        <\/a>[\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column width=&#8221;2\/3&#8243;][vc_column_text css=&#8221;&#8221;] Expertise: We offer a robust research program including many Clinical trials and innovative research for patients with Parkinson\u2019s Disease and other movement disorders.[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column width=&#8221;5\/6&#8243;][\/vc_column][vc_column width=&#8221;1\/6&#8243;][\/vc_column][\/vc_row]<\/p>\n","protected":false},"author":226,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-4915","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.2 - 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