{"id":1158,"date":"2018-12-20T15:55:45","date_gmt":"2018-12-20T15:55:45","guid":{"rendered":"https:\/\/wp.uthscsa.edu\/pathology\/?page_id=1158"},"modified":"2018-12-20T15:55:45","modified_gmt":"2018-12-20T15:55:45","slug":"chromosome-analysis-product-of-conception","status":"publish","type":"page","link":"https:\/\/lsom.uthscsa.edu\/pathology\/reference-labs\/clinical-molecular-cytogenetics\/chromosome-analysis-product-of-conception\/","title":{"rendered":"Chromosome Analysis \u2013\u00a0Product of Conception"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row][vc_column width=&#8221;2\/3&#8243;][vc_column_text]Test Overview<\/p>\n<p><strong>CPT Code(s)<\/strong><\/p>\n<p>88233, 88262, 88280, 88291<\/p>\n<p><strong>Methodology<\/strong><\/p>\n<p>Culture \/ Microscopy \/ Karyotype<\/p>\n<p><strong>Specimen Requirements<\/strong><\/p>\n<p>Placenta, umbilical cord, and internal fetal organs\u00a0are all\u00a0suitable for analysis.\u00a0\u00a0If possible, please\u00a0send\u00a0chorionic villi.<\/p>\n<p>Container:\u00a0\u00a0Sterile, leak-proof containers with transport media or sterile saline (i.e.\u00a0Hanks Balanced Salt Solution).\u00a0<strong>Do not place in formalin.<\/strong><\/p>\n<p>Optimal Quantity:\u00a01x1x1 cm of at least two fetal tissues, one being chorionic villi<\/p>\n<p>Minimum Quantity: 1 fetal tissue<\/p>\n<p>Storage: Room Temperature<\/p>\n<p>Stability at Room Temperature: 8 hours, then refrigerate<\/p>\n<p>Transportation: Avoid freezing or heating over 35<sup>O<\/sup>C<\/p>\n<p><strong>Turnaround Time<\/strong><\/p>\n<p>Final report in 14-28 days<\/p>\n<p>Test Detail<\/p>\n<p><strong>Clinical Significance<\/strong><\/p>\n<p>Indications for cytogenetic analysis on\u00a0products of conception (POC)\u00a0include recurrent spontaneous abortions, abnormalities on ultrasound prior to pregnancy loss, intrauterine growth retardation, confirmation of abnormal prenatal results or pregnancy loss after IVF.<\/p>\n<p><strong>Clinical Background<\/strong><\/p>\n<p>Fetal tissues or extra embryonic membranes are frequently used to diagnose fetal chromosome abnormalities that are associated with approximately one-half of all first trimester spontaneous abortions. The most common chromosome abnormalities seen in spontaneous miscarriages are trisomy 16 and\u00a0monosomy\u00a0X.\u00a0\u00a0In some cases where the POC karyotype revealed a structural rearrangement, parental chromosome analysis is requested. The diagnosis of an abnormal karyotype in a POC may provide a chromosomal basis for the pregnancy loss. It may also help in clarifying the risk for future miscarriages or for the birth of a chromosomally abnormal child.\u00a0Abnormal POC cytogenetic results may preclude the need for extensive infertility evaluation.<\/p>\n<p><strong>Methods<\/strong><\/p>\n<p>Tissues from products of conception are cultured to produce metaphase cells for G-banded chromosome analysis<strong>.\u00a0<\/strong>Long term cultures are harvested at approximately 10-14 days, then G-banded.\u00a0\u00a0Analysis and karyotyping of 20 metaphases is routinely performed and additional metaphases will be studied when indicated.<\/p>\n<p><strong>Interpretation of Results<\/strong><\/p>\n<p>The morphologic interpretation and correlation of results on all cases is performed by a board-certified doctoral level scientist (laboratory director).<strong>\u00a0<\/strong>The final report identifies the chromosomal sex and modal chromosome number.\u00a0\u00a0If abnormalities are present, they are explained in a paragraph which helps to clarify and correlate chromosomal findings with phenotype. Genetic counseling is recommended when chromosome aberrations, mosaic conditions, or unusual results are found, along with recommendation for further testing (i.e. microarray).\u00a0\u00a0References are included in the report to help the referring physician with interpretation, which include books or journals that contain appropriate information.[\/vc_column_text][\/vc_column][vc_column width=&#8221;1\/3&#8243;][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column width=&#8221;2\/3&#8243;][vc_column_text]Test Overview CPT Code(s) 88233, 88262, 88280, 88291 Methodology Culture \/ Microscopy \/ Karyotype Specimen Requirements Placenta, umbilical cord, and internal fetal organs\u00a0are all\u00a0suitable for analysis.\u00a0\u00a0If possible, please\u00a0send\u00a0chorionic villi. Container:\u00a0\u00a0Sterile, leak-proof containers with transport media or sterile saline (i.e.\u00a0Hanks Balanced Salt Solution).\u00a0Do not place in formalin. Optimal Quantity:\u00a01x1x1 cm of at least two fetal [&hellip;]<\/p>\n","protected":false},"author":161,"featured_media":0,"parent":615,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"page-templates\/child-page.php","meta":{"footnotes":""},"class_list":["post-1158","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Chromosome Analysis \u2013\u00a0Product of Conception - Department of Pathology and Laboratory Medicine<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/lsom.uthscsa.edu\/pathology\/reference-labs\/clinical-molecular-cytogenetics\/chromosome-analysis-product-of-conception\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Chromosome Analysis \u2013\u00a0Product of Conception - Department of Pathology and Laboratory Medicine\" \/>\n<meta property=\"og:description\" content=\"[vc_row][vc_column width=&#8221;2\/3&#8243;][vc_column_text]Test Overview CPT Code(s) 88233, 88262, 88280, 88291 Methodology Culture \/ Microscopy \/ Karyotype Specimen Requirements Placenta, umbilical cord, and internal fetal organs\u00a0are all\u00a0suitable for analysis.\u00a0\u00a0If possible, please\u00a0send\u00a0chorionic villi. 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