{"id":550,"date":"2018-12-07T20:38:51","date_gmt":"2018-12-07T20:38:51","guid":{"rendered":"https:\/\/wp.uthscsa.edu\/pathology\/?page_id=550"},"modified":"2018-12-07T20:38:51","modified_gmt":"2018-12-07T20:38:51","slug":"diabetes-research","status":"publish","type":"page","link":"https:\/\/lsom.uthscsa.edu\/pathology\/research\/diabetes-research\/","title":{"rendered":"Diabetes Research"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row][vc_column width=&#8221;2\/3&#8243;][vc_column_text]<span style=\"font-weight: 400\">Diabetes is a complex syndrome resulting from derangement of carbohydrate metabolism that is caused by either a relative or absolute deficiency in insulin. The complexity of this disease reflects the enormous variability in biochemical and clinical alterations that occur when blood glucose concentrations are excessively elevated. The medical complications of long-standing diabetes are associated with significant morbidity and mortality. This includes occlusive cardiovascular disease (atherosclerotic heart disease, ischemic stroke, and peripheral vascular disease leading to gangrene\/amputation), neuropathy, retinopathy (blindness), nephropathy (renal failure), and infections.<\/span><\/p>\n<p><span style=\"font-weight: 400\">Research efforts in this department target improved understanding of glucose-dependent alterations in vascular endothelial cell and white blood cell (neutrophil) function. Thus, cultured human endothelial cells are used to examine the effects of glucose on gene expression and intracellular signaling. And, neutrophils from the blood of diabetic subjects are isolated for investigations of glucose-dependent dysfunction of G-protein coupled receptors.<\/span><\/p>\n<h3>Pathology Faculty<\/h3>\n<p><a href=\"http:\/\/profiles.uthscsa.edu\/?pid=profile&amp;id=0V71EBYVE\"><span style=\"font-weight: 400\">Sumathy Mohan, Ph.D<\/span><\/a>[\/vc_column_text][\/vc_column][vc_column width=&#8221;1\/3&#8243;][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column width=&#8221;2\/3&#8243;][vc_column_text]Diabetes is a complex syndrome resulting from derangement of carbohydrate metabolism that is caused by either a relative or absolute deficiency in insulin. The complexity of this disease reflects the enormous variability in biochemical and clinical alterations that occur when blood glucose concentrations are excessively elevated. The medical complications of long-standing diabetes are associated [&hellip;]<\/p>\n","protected":false},"author":161,"featured_media":0,"parent":15,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"page-templates\/child-page.php","meta":{"footnotes":""},"class_list":["post-550","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Diabetes Research - Department of Pathology and Laboratory Medicine<\/title>\n<meta name=\"description\" content=\"Diabetes research target improved understanding of glucose-dependent alterations in vascular endothelial cell and white blood cell (neutrophil) function.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/lsom.uthscsa.edu\/pathology\/research\/diabetes-research\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Diabetes Research - Department of Pathology and Laboratory Medicine\" \/>\n<meta property=\"og:description\" content=\"Diabetes research target improved understanding of glucose-dependent alterations in vascular endothelial cell and white blood cell (neutrophil) function.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/lsom.uthscsa.edu\/pathology\/research\/diabetes-research\/\" \/>\n<meta property=\"og:site_name\" content=\"Department of Pathology and Laboratory Medicine\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/lsom.uthscsa.edu\/pathology\/research\/diabetes-research\/\",\"url\":\"https:\/\/lsom.uthscsa.edu\/pathology\/research\/diabetes-research\/\",\"name\":\"Diabetes Research - Department of Pathology and Laboratory Medicine\",\"isPartOf\":{\"@id\":\"https:\/\/lsom.uthscsa.edu\/pathology\/#website\"},\"datePublished\":\"2018-12-07T20:38:51+00:00\",\"description\":\"Diabetes research target improved understanding of glucose-dependent alterations in vascular endothelial cell and white blood cell (neutrophil) function.\",\"breadcrumb\":{\"@id\":\"https:\/\/lsom.uthscsa.edu\/pathology\/research\/diabetes-research\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/lsom.uthscsa.edu\/pathology\/research\/diabetes-research\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/lsom.uthscsa.edu\/pathology\/research\/diabetes-research\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/lsom.uthscsa.edu\/pathology\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Research\",\"item\":\"https:\/\/lsom.uthscsa.edu\/pathology\/research\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Diabetes Research\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/lsom.uthscsa.edu\/pathology\/#website\",\"url\":\"https:\/\/lsom.uthscsa.edu\/pathology\/\",\"name\":\"Department of Pathology and Laboratory Medicine\",\"description\":\"Department of Pathology and Laboratory Medicine\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/lsom.uthscsa.edu\/pathology\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Diabetes Research - Department of Pathology and Laboratory Medicine","description":"Diabetes research target improved understanding of glucose-dependent alterations in vascular endothelial cell and white blood cell (neutrophil) function.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/lsom.uthscsa.edu\/pathology\/research\/diabetes-research\/","og_locale":"en_US","og_type":"article","og_title":"Diabetes Research - Department of Pathology and Laboratory Medicine","og_description":"Diabetes research target improved understanding of glucose-dependent alterations in vascular endothelial cell and white blood cell (neutrophil) function.","og_url":"https:\/\/lsom.uthscsa.edu\/pathology\/research\/diabetes-research\/","og_site_name":"Department of Pathology and Laboratory Medicine","twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/lsom.uthscsa.edu\/pathology\/research\/diabetes-research\/","url":"https:\/\/lsom.uthscsa.edu\/pathology\/research\/diabetes-research\/","name":"Diabetes Research - Department of Pathology and Laboratory Medicine","isPartOf":{"@id":"https:\/\/lsom.uthscsa.edu\/pathology\/#website"},"datePublished":"2018-12-07T20:38:51+00:00","description":"Diabetes research target improved understanding of glucose-dependent alterations in vascular endothelial cell and white blood cell (neutrophil) function.","breadcrumb":{"@id":"https:\/\/lsom.uthscsa.edu\/pathology\/research\/diabetes-research\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/lsom.uthscsa.edu\/pathology\/research\/diabetes-research\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/lsom.uthscsa.edu\/pathology\/research\/diabetes-research\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/lsom.uthscsa.edu\/pathology\/"},{"@type":"ListItem","position":2,"name":"Research","item":"https:\/\/lsom.uthscsa.edu\/pathology\/research\/"},{"@type":"ListItem","position":3,"name":"Diabetes Research"}]},{"@type":"WebSite","@id":"https:\/\/lsom.uthscsa.edu\/pathology\/#website","url":"https:\/\/lsom.uthscsa.edu\/pathology\/","name":"Department of Pathology and Laboratory Medicine","description":"Department of Pathology and Laboratory Medicine","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/lsom.uthscsa.edu\/pathology\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"}]}},"_links":{"self":[{"href":"https:\/\/lsom.uthscsa.edu\/pathology\/wp-json\/wp\/v2\/pages\/550","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lsom.uthscsa.edu\/pathology\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/lsom.uthscsa.edu\/pathology\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/lsom.uthscsa.edu\/pathology\/wp-json\/wp\/v2\/users\/161"}],"replies":[{"embeddable":true,"href":"https:\/\/lsom.uthscsa.edu\/pathology\/wp-json\/wp\/v2\/comments?post=550"}],"version-history":[{"count":0,"href":"https:\/\/lsom.uthscsa.edu\/pathology\/wp-json\/wp\/v2\/pages\/550\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/lsom.uthscsa.edu\/pathology\/wp-json\/wp\/v2\/pages\/15"}],"wp:attachment":[{"href":"https:\/\/lsom.uthscsa.edu\/pathology\/wp-json\/wp\/v2\/media?parent=550"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}