Researchers Discover Proteins in the Brain That Protect Synapses From Being Eliminated

Gek-Ming Sia

Gek-Ming Sia, Ph.D., of the University of Texas Health Science Center in San Antonio, devoted his 2016 BBRF Young Investigator grant to comprehensive study of a protein called SRPX2, which had been linked with increasing the number of synapses formed by neurons in the brain’s cerebral cortex. In a paper recently published in Nature Neuroscience, Dr. Sia and colleagues show that this protein, SRPX2, is present in the brain, and, rather than promoting the formation of new synapses, actually acts to inhibit the mechanism designed to eliminate synapses.

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Posted: September 3, 2020

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