Seminar – Joseph L. Witztum, M.D.
Event Date & TimeDecember 15, 2022 at 12 Noon
DEPARTMENT OF PHARMACOLOGY
Thursday, December 15, 2022
12:00pm – 409L LSOM
Joseph L. Witztum, M.D.
Distinguished Professor of Medicine
Division of Endocrinology and Metabolism
University of California, San Diego
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About the Speaker(s)
Joseph L. Witztum, MD is a Distinguished Professor of Medicine in the Division of Endocrinology and Metabolism at the University of California, San Diego. For more than 40 years, Dr. Witztum has made major contributions to the field of atherosclerosis. Alongside Dr. Daniel Steinberg, he first described the role of OxLDL in atherogenesis, providing fundamental information on its properties and evidence that it existed in experimental models and humans. He first showed that OxLDL was immunogenic, leading to both adaptive and innate immune responses to what he termed “oxidation-specific epitopes,” which fundamentally contributed to the concept that atherosclerosis was a chronic inflammatory disease. After discovering the IgM natural antibody E06 that specifically bound and neutralized oxidized phospholipids (OxPL), he and his colleagues have shown the central role of OxPL in mediating inflammation and toxicity in a wide variety of settings. Using transgenic mice that express the E06 antibody, they have shown that targeting OxPL ameliorates many disease processes, including atherosclerosis, NASH, myocardial ischemia-reperfusion and osteoporosis.