Seminar – Valentina R Garbarino, PhD

Throughout my research training, I have utilized cell culture models, mouse models of tauopathies, naked mole rats and a aging and resilience model, and worked with clinical populations relevant to healthy brain aging and neurodegenerative disease. I currently oversee two clinical trial studies evaluating safety and efficacy of repurposed medications (senolytics, mTOR inhibitor rapamycin), to therapeutically target aberrant pathway activity related to Alzheimer’s disease. Being able to ask questions and design experiments relevant to multiple parts of the translational science spectrum has been a great asset to my scientific repertoire, and has provided a broader vision for my work. Exploring the role of chronic stress on Alzheimer’s disease risk and pathophysiology is the focus of my independent research projects. My goal is to identify new health and disease state biofluid biomarkers (saliva, plasma) and potential therapeutic strategies and interventions for Alzheimer’s disease in clinical populations.

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