Contact

Location: 5.249S Dr. Risinger Lab

Department

Pharmacology

Charles S. Fermaintt

Postdoctoral Fellow

Personal Statement:

As a postdoctoral fellow under the mentorship of Dr. April Risinger, I am focusing in identifying and characterizing drugs derived from natural sources like plants and fungi that could be used to develop more effective cancer-immunotherapies against breast cancer in particular triple negative breast cancer (TNBC). I am also examining the influence clinically used chemotherapy agents like microtubule targeting agents on the innate immune system.


Education

Ph.D., Biological Chemistry, University of Texas Southwestern Medical Center, Dallas TX
B.S., Chemistry, University of Puerto Rico at Humacao, Humacao PR

Research

Breast Cancer, Natural Products, Innate Immunity, Microtubule Targeting Agents, Drug discovery

Awards & Accomplishments

Honors, Fellowships and Scholarships
UT-Health San Antonio SABER (IRACDA) Scholar
NIH RO1 Research Supplement  (NIH Admin Supp)
National Science Foundation (NSF) Graduate Research Fellowship Program (GRFP)
Postbaccalaureate Research Education Program (PREP) (R25 NIH Training Grant)
Minority Access to Research Careers (MARC) (T34 NIH Training Grant)
AMGEN Foundation BioMinds Research Program
Puerto Rico Louis Stokes Alliance for Minority Participation (PR-LSAMP)
UPR-Humacao Academic Scholarship
AMGEN Foundation Scholarship
 
Awards –
UT-Southwestern Nominata Award Biological Chemistry Graduate Program nominee
Biological Chemistry Symposium Best Poster Presentation Award
Society for Glycobiology Annual Meeting Travel award
UT-Southwestern Nominata Award Biological Chemistry Graduate Program nominee
Society for Glycobiology Annual Meeting Travel award
Society for Glycobiology Annual Meeting Travel award

Publications

Fermaintt C.S., Sano K., Liu Z., Ishii N., Seino J., Dobbs N., Suzuki T., Fu Y., Lehrman M.A., Matsuo I. and Yan N. A bioactive mammalian disaccharide activates a STING-TBK1-dependent immune response associated with chronic autoimmune disease. Nature Communications May 30, 2019​

 Lu H., Fermaintt C.S., Yan N. and Lehrman M.A. Mammalian oligosaccharyltransferases segregate LLO donor hydrolysis from N-glycosylation at the translocon. PNAS September 18, 2018 

Sakai T., Miyazaki T., Shin D., Kim Y., Qi C., Fariss R., Munasinghe J., Wang H., Kovalchuk A.L., Kothari P.H., Fermaintt C.S., Atkinson J.P., Perrino F.W., Yan N., Morse III H.C. DNase-active TREX1 frame-shift mutants induce serologic autoimmunity in mice. Journal of Autoimmunity March 18, 2017
 Kucej M.*, Fermaintt C.S.*, Yang K., Irizarry-Caro R. and Yan N. Mitotic phosphorylation of TREX1 C-terminus disrupts TREX1 regulation of the oligosaccharyltransferase complex. Cell Reports March 14, 2017 *Co-first author

 Hasan M.*, Fermaintt C.S.*, Gao N., Sakai T., Miyazaki T., Jiang S., Li Q., Atkinson J.P., Morse III H.C., Lehrman M.A. and Yan N. A novel function of TREX1 associated with the C-terminus connects oligosaccharyltransferase dysregulation to immune disorders. Immunity September 15, 2015 *Co-first author

 Pham N.D., Fermaintt C.S., Rodriguez A.C., McCombs J.E., Nischan N and Kohler J.J. Cellular metabolism of unnatural sialic acid precursors. Glycoconjugate Journal May 10, 2015​