{"id":667,"date":"2018-12-19T20:44:22","date_gmt":"2018-12-19T20:44:22","guid":{"rendered":"https:\/\/wp.uthscsa.edu\/pharmacology\/?page_id=667"},"modified":"2018-12-19T20:44:22","modified_gmt":"2018-12-19T20:44:22","slug":"david-morilak-ph-d","status":"publish","type":"page","link":"https:\/\/lsom.uthscsa.edu\/pharmacology\/cross-appointed-faculty\/david-morilak-ph-d\/","title":{"rendered":"David Morilak, Ph.D."},"content":{"rendered":"

[vc_row][vc_column width=”2\/3″][vc_column_text]<\/p>\n

Center for Biomedical Neuroscience<\/span><\/a>, Director<\/span><\/h3>\n

Professor of Pharmacology<\/span><\/h3>\n

Ph.D., Princeton University<\/span>
\nOffice:<\/strong> 210-567-4174<\/span>
\nEmail:<\/strong> morilak@uthscsa.edu<\/span>
\nView a video introduction to Dr. Morilak’s Lab>><\/a>
\nResearch Interests<\/b><\/p>\n\n\n\n\n\n\n\n\n
\u2022 antidepressants<\/span><\/td>\n\u2022 anxiety<\/span><\/td>\n<\/tr>\n
\u2022 behavior<\/span><\/td>\n\u2022 cognition<\/span><\/td>\n<\/tr>\n
\u2022 depression<\/span><\/td>\n\u2022 HPA axis<\/span><\/td>\n<\/tr>\n
\u2022 in situ hybridization \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0<\/span><\/td>\n\u2022 microdialysis<\/span><\/td>\n<\/tr>\n
\u2022 norepinephrine<\/span><\/td>\n\u2022 PTSD<\/span><\/td>\n<\/tr>\n
\u2022 stress<\/span><\/td>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Research Activities<\/b>
\nWe study the negative impact of stress, and mechanisms for better treatment of stress-related psychiatric disorders. Our research addresses a) regulation and integration of the acute behavioral, cognitive and endocrine responses to stress; b) adaptive and maladaptive responses to chronic stress; and c) regulatory mechanisms of action of psychotherapeutic drugs and other types of therapeutic interventions, including behavioral therapies. One focus of our research over the years has been on norepinephrine (NE), an important neuromodulatory transmitter that plays a critical role in the acute response to stress by enhancing arousal and sensorimotor response capabilities, and by integrating autonomic and endocrine responses with behavior. We study the role of NE in modulating behavioral and neuroendocrine responses to acute stress, and enhancing higher-order cognitive processes mediated in the prefrontal cortex related to cognitive flexibility and coping behavior. Our techniques span the range from molecular, cellular and neural circuit to whole animal behavior and cognition. We study structural, functional and regulatory changes in prefrontal circuits that underly neuronal plasticity, the basis of both stress-induced pathology and therapeutic efficacy. Our work is relevant to understanding stress-related pathology underlying illnesses such as depression, PTSD or anxiety disorders, and the beneficial effects of antidepressant and anxiolytic therapies. Experimental approaches include behavioral tests of cognition, arousal, anxiety and defensive responses; intracerebral drug microinjections; in vivo microdialysis to measure neurotransmitter release in behaving rats; in situ hybridization, immunohistochemistry and receptor autoradiography; radioimmunoassay for plasma hormone measures; electrophysiology to assess plasticity in ascending and descending corticolimbic circuits; viral-based chemo- and optogenetics, western blots, IP assays and other measures of protein regulation and signal transduction; and the application of chronic metabolic and psychogenic stressors.<\/span>
\n 
\n Accomplishments, Awards and Honors\u00a0<\/b><\/p>\n