{"id":760,"date":"2018-12-19T23:23:19","date_gmt":"2018-12-19T23:23:19","guid":{"rendered":"https:\/\/wp.uthscsa.edu\/pharmacology\/?page_id=760"},"modified":"2018-12-19T23:23:19","modified_gmt":"2018-12-19T23:23:19","slug":"juli-bai","status":"publish","type":"page","link":"https:\/\/lsom.uthscsa.edu\/pharmacology\/research-faculty\/juli-bai\/","title":{"rendered":"Juli Bai"},"content":{"rendered":"

[vc_row][vc_column width=”2\/3″][vc_column_text]<\/p>\n

Instructor\/Research<\/span><\/h3>\n

Ph.D., Environmental Medicine and Toxicology<\/span><\/p>\n

University of Shanxi<\/span><\/p>\n

Taiyuan, China<\/span><\/p>\n

Lab:<\/strong> 210-567-4526<\/span><\/p>\n

Email:<\/strong> baij@uthscsa.edu<\/span><\/p>\n

Lab Association:<\/span> Feng Liu, Ph.D.<\/span><\/a><\/p>\n

Research Interests<\/b><\/p>\n\n\n\n\n\n
\u2022 obesity \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0<\/span><\/td>\n\u2022 diabetes<\/span><\/td>\n<\/tr>\n
\u2022 inflammation<\/span><\/td>\n\u2022 immunometabolism<\/span><\/td>\n<\/tr>\n
\u2022 energy homeostasis<\/span><\/td>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Research Summary<\/b><\/p>\n

Obesity, which is characterized by increased adiposity, has reached epidemic proportions globally. Numerous studies have shown that chronic sterile inflammation in white adipose tissue (WAT), a major depot for chemical energy storage in the form of triglyceride (TG) and for hormone and cytokine production in response to nutritional and environmental changes, plays a key role in triggering insulin resistance and its associated metabolic diseases. In contrast to WAT, the major function of brown adipose tissue (BAT) and beige adipose tissue (bAT) is to dissipate chemical energy as heat via high levels of mitochondrial uncoupling protein 1 (UCP-1) to counteract hypothermia and obesity. Increasing thermogenesis and suppressing inflammation have been demonstrated to exert a great metabolic benefit against diet-induced obesity and insulin resistance.<\/span><\/p>\n

The major focus of my research effort concerns the mechanisms of obesity-induced insulin resistance, sterile chronic inflammation, and energy imbalance. Particularly, I\u2019m interested in how obesity leads to mitochondrial dysfunction and how adipocytes crosstalk with other cell types to regulate energy homeostasis in WAT, BAT as wells as in other metabolic tissues. Better understanding of the mechanism underlying obesity-induced metabolic dysfunction will provide important information for the development of new therapeutic targets for the treatment of obesity and its related diseases.<\/span><\/p>\n

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Accomplishments, Awards and Honors \u2022<\/b><\/p>\n