{"id":847,"date":"2018-12-20T01:30:57","date_gmt":"2018-12-20T01:30:57","guid":{"rendered":"https:\/\/wp.uthscsa.edu\/pharmacology\/?page_id=847"},"modified":"2018-12-20T01:30:57","modified_gmt":"2018-12-20T01:30:57","slug":"jennifer-donegan","status":"publish","type":"page","link":"https:\/\/lsom.uthscsa.edu\/pharmacology\/jennifer-donegan\/","title":{"rendered":"Jennifer Donegan"},"content":{"rendered":"<h3><span style=\"font-weight: 400\">Postdoctoral Fellow<\/span><\/h3>\n<p><span style=\"font-weight: 400\">Ph.D., Neuroscience<\/span><br \/>\n<span style=\"font-weight: 400\">UT Health San Antonio<\/span><br \/>\n<span style=\"font-weight: 400\">San Antonio, Texas<\/span><br \/>\n<span style=\"font-weight: 400\"><strong>Lab:<\/strong> 210-567-4273<\/span><br \/>\n<span style=\"font-weight: 400\"><strong>Email:<\/strong> donegan@uthscsa.edu<\/span><br \/>\n<span style=\"font-weight: 400\">Lab Association:<\/span><a href=\"http:\/\/lsom.uthscsa.edu\/pharmacology\/faculty-2\/daniel-lodge\/\"> <span style=\"font-weight: 400\">Daniel Lodge, Ph.D.<\/span><\/a><br \/>\n<b>Research Interests<\/b><\/p>\n<table>\n<tbody>\n<tr>\n<td><span style=\"font-weight: 400\">\u2022 schizophrenia \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400\">\u2022 stem cells<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400\">\u2022 dopamine<\/span><\/td>\n<td><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><b>Research Summary<\/b><br \/>\n<span style=\"font-weight: 400\">My research is exploring the use of embryonic stem cells to reverse deficits in a developmental model of schizophrenia. Schizophrenic patients show changes in inhibitory GABAergic interneurons, which are thought to underlie behavioral and physiological symptoms of the disorder. Using a battery of behavioral assays and in vivo extracellular electrophysiology, we are testing the hypothesis that GABAergic interneurons, derived from embryonic stem cells, can reverse the schizophrenia-like changes seen in our rodent model.<\/span><br \/>\n&nbsp;<br \/>\n<b> Accomplishments, Awards and Honors\u00a0<\/b><br \/>\n<span style=\"font-weight: 400\">UT Health San Antonio Center for Biomedical Neuroscience (CBN) Annual Retreat Poster Award &#8211; May 2016<\/span><br \/>\n<span style=\"font-weight: 400\">Schizophrenia International Research Society Poster Award Finalist &#8211; April 2016<\/span><br \/>\n<span style=\"font-weight: 400\">Schizophrenia International Research Society Travel Award &#8211; Feb 2016<\/span><br \/>\n<span style=\"font-weight: 400\">UT Health San Antonio Pharmacology Graduate Student Symposium Poster Award &#8211; Nov 2015<\/span><br \/>\n<span style=\"font-weight: 400\">William Thomas Booth Travel Award -UT Health San Antonio Pharmacology &#8211; August 2015<\/span><br \/>\n<span style=\"font-weight: 400\">UT Health San Antonio Center for Biomedical Neuroscience (CBN) Annual Retreat Poster Award &#8211; May 2015<\/span><br \/>\n<span style=\"font-weight: 400\">HSC News &#8211;<\/span><a href=\"https:\/\/news.uthscsa.edu\/low-levels-of-pro-inflammatory-agent-help-cognition-in-rats\/\"> <i><span style=\"font-weight: 400\">&#8216;Low levels of pro-inflammatory agent help cognition in rats&#8217;<\/span><\/i><\/a><span style=\"font-weight: 400\"> &#8211; Feb 2014<\/span><br \/>\n<span style=\"font-weight: 400\">Society for Neuroscience (SfN) Meeting Travel Award &#8211; 2013<\/span><br \/>\n&nbsp;<br \/>\n<b> Appointments, Boards, Committees, and Memberships\u00a0<\/b><br \/>\n<span style=\"font-weight: 400\">Society for Neuroscience (SfN)<\/span><br \/>\n&nbsp;<br \/>\n<b> Lectures and Presentations\u00a0<\/b><\/p>\n<ul>\n<li><span style=\"font-weight: 400\">ASPET Undergraduate Research Program &#8211; Lecture on Synaptic Transmission &#8211; Summer 2014-2017<\/span><\/li>\n<li><span style=\"font-weight: 400\">ASPET Undergraduate Research Program &#8211; Lecture on Cell Culture Techniques &#8211; Summer 2014-2017<\/span><\/li>\n<\/ul>\n<p>&nbsp;<br \/>\n<b>Selected Publications<\/b><\/p>\n<ul>\n<li style=\"font-weight: 400\"><b>Donegan, J.J.<\/b><span style=\"font-weight: 400\">, Boley, A.M., and Lodge, D.J. (2018) Stem cell derived interneuron transplants in a rodent model of autism <\/span><i><span style=\"font-weight: 400\">Neuropsychopharmacology<\/span><\/i><span style=\"font-weight: 400\"> Article accepted<\/span><\/li>\n<li style=\"font-weight: 400\"><b>Donegan, J.J.<\/b><span style=\"font-weight: 400\"> and Lodge, D.J. (2017)<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27806991\"> <span style=\"font-weight: 400\">Perineuronal nets in the ventral hippocampus are required for the long-lasting antidepressant effects of ketamine<\/span><\/a> <i><span style=\"font-weight: 400\">Int J Neuropsychopharmacol.<\/span><\/i><span style=\"font-weight: 400\"> Apr 1;20(4): 354-358 doi: 10.1093\/ijnp\/pyw095 PMID: 27806991<\/span><\/li>\n<li style=\"font-weight: 400\"><b>Donegan, J.J.<\/b><span style=\"font-weight: 400\"> and Lodge, D.J. (2017)<\/span><a href=\"http:\/\/lsom.uthscsa.edu\/pharmacology\/postdocs\/Donegan,%20J.J.%20and%20Lodge,%20D.J.%20%E2%80%9CCell-based%20therapies%20for%20the%20treatment%20of%20schizophrenia.%E2%80%9D%20Brain%20Research,%202017,%201655:%20262-269\"> <span style=\"font-weight: 400\">Cell-based therapies for the treatment of schizophrenia<\/span><\/a> <i><span style=\"font-weight: 400\">Brain Res.<\/span><\/i><span style=\"font-weight: 400\"> Jan 15;1655: 262-269 doi: 10.1016\/j.brainres.2016.08.010. Epub 2016 Aug 18. PMID: 27544423<\/span><\/li>\n<li style=\"font-weight: 400\"><b>Donegan, J.J.<\/b><span style=\"font-weight: 400\">, Tyson, J.A., Branch, S. Y., Beckstead, M.J., Anderson, S. A., Lodge, D.J. (2017)<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27480492\"> <span style=\"font-weight: 400\">Stem cell derived interneuron transplants as a treatment for schizophrenia: preclinical validation in a rodent model<\/span><\/a> <i><span style=\"font-weight: 400\">Mol Psychiatry<\/span><\/i><span style=\"font-weight: 400\"> Oct;22(10): 1492-1501 doi: 10.1038\/mp.2016.121. Epub 2016 Aug 2 PMID: 27480492<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Carreno, F.R., <\/span><b>Donegan, J.J.<\/b><span style=\"font-weight: 400\">, Boley, A.M., Shah, A., DeGuzman, M., Frazer, A., and Lodge, D.J. (2016)<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26619811\"> <span style=\"font-weight: 400\">Activation of a ventral hippocampus-medial prefrontal cortex pathway is both necessary and sufficient for an antidepressant response to ketamine<\/span><\/a> <i><span style=\"font-weight: 400\">Mol Psychiatry.<\/span><\/i><span style=\"font-weight: 400\"> Sep;21(9): 1298-308 doi: 10.1038\/mp.2015.176. Epub 2015 Dec 1. PMID: 26619811<\/span><\/li>\n<li style=\"font-weight: 400\"><b>Selected Abstracts<\/b><\/li>\n<li style=\"font-weight: 400\"><b>Donegan, J.J.<\/b><span style=\"font-weight: 400\">, Boley, A.M., Lodge, D.J. <\/span><i><span style=\"font-weight: 400\">Embryonic Stem Cell Transplants as a Therapeutic Strategy in a Rodent Model of Autism<\/span><\/i><span style=\"font-weight: 400\"> &#8211; Society for Neuroscience &#8211; San Diego, CA. 2016<\/span><\/li>\n<li style=\"font-weight: 400\"><b>Donegan, J.J.<\/b><span style=\"font-weight: 400\"> and Lodge, D.J. <\/span><i><span style=\"font-weight: 400\">Contribution of Hippocampal Projections to Discrete Symptoms of Schizophrenia<\/span><\/i><span style=\"font-weight: 400\"> &#8211; UTHSCSA Department of Pharmacology Graduate Student Symposium &#8211; San Antonio, TX. 2016<\/span><\/li>\n<li style=\"font-weight: 400\"><b>Donegan, J.J.<\/b><span style=\"font-weight: 400\">, Boley, A.M., Lodge, D.J. <\/span><i><span style=\"font-weight: 400\">Embryonic Stem Cell Transplants as a Therapeutic Strategy in a Rodent Model of Autism<\/span><\/i><span style=\"font-weight: 400\"> &#8211; Center for Biomedical Neurosciences Retreat &#8211; San Antonio, TX. 2016<\/span><\/li>\n<li style=\"font-weight: 400\"><b>Donegan, J.J.<\/b><span style=\"font-weight: 400\">, Tyson, J.A., Branch, S.Y., Beckstead, M.J., Anderson, S.A., Lodge, D.J. <\/span><i><span style=\"font-weight: 400\">Embryonic stem cell transplants as a therapeutic strategy in a rodent model of schizophrenia<\/span><\/i><span style=\"font-weight: 400\"> &#8211; Schizophrenia International Research Society &#8211; Florence, Italy 2016)<\/span><\/li>\n<li style=\"font-weight: 400\"><b>Donegan, J.J.<\/b><span style=\"font-weight: 400\">, Tyson, J.A., Anderson, S.A., Lodge, D.J. <\/span><i><span style=\"font-weight: 400\">Embryonic stem cell transplants as a therapeutic strategy in a rodent model of schizophrenia<\/span><\/i><span style=\"font-weight: 400\"> &#8211; Society for Neuroscience &#8211; Chicago, IL. 2015<\/span><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Postdoctoral Fellow Ph.D., Neuroscience UT Health San Antonio San Antonio, Texas Lab: 210-567-4273 Email: donegan@uthscsa.edu Lab Association: Daniel Lodge, Ph.D. Research Interests \u2022 schizophrenia \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u2022 stem cells \u2022 dopamine Research Summary My research is exploring the use of embryonic stem cells to reverse deficits in a developmental model of schizophrenia. Schizophrenic patients show changes [&hellip;]<\/p>\n","protected":false},"author":10,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"page-templates\/child-page.php","meta":{"footnotes":""},"class_list":["post-847","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Jennifer Donegan - Department of Pharmacology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/lsom.uthscsa.edu\/pharmacology\/jennifer-donegan\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Jennifer Donegan - Department of Pharmacology\" \/>\n<meta property=\"og:description\" content=\"Postdoctoral Fellow Ph.D., Neuroscience UT Health San Antonio San Antonio, Texas Lab: 210-567-4273 Email: donegan@uthscsa.edu Lab Association: Daniel Lodge, Ph.D. Research Interests \u2022 schizophrenia \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u2022 stem cells \u2022 dopamine Research Summary My research is exploring the use of embryonic stem cells to reverse deficits in a developmental model of schizophrenia. 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