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Seminar Series – “The role of astrocyte cholesterol in neuroinflammation”

Event Details:
Seminar Flyer - Scott Hansen

Summary:
My lab studies the role of astrocyte derived cholesterol in controlling neurons and microglia. In Alzheimer's models, astroctye cholesterol is transported to neurons to control the production of amyloid and Tau proteins. The same cholesterol is transported to microglia where it regulates cytokine production. Under homeostatic conditions the cholesterol regulates the excitability of neurons by regulating the nanoscopic location of enzymes and ion channel. We use two-color super resolution imaging to follow nanoscopic sorting of proteins with cholesterol and the signaling lipid PIP2.