DepartmentCellular and Integrative Physiology
Wan-Chen (Amy) Wu
IBMS Neuroscience Discipline
Jason Pugh, Ph.D.
Hobbies and Interests:
Film score, musical and jogging
MS, Biomedical Sciences
Icahn School of Medicine at Mount Sinai - New York, NY
BS, Physical Therapy
China Medical University - Taichung, Taiwan
Duchenne muscular dystrophy is caused by mutations in the gene for dystrophin. This protein is highly expressed in muscle tissue and loss of dystrophin results in muscle weakness and degeneration. However, dystrophin is also expressed in the central nervous system, with the highest expression in cerebellar Purkinje cells. Amy will investigate the consequences of loss of dystrophin on synaptic transmission and firing in Purkinje cells using acute brain slice and in vivo electrophysiology.
Khatri SN, Wu WC, Yang Y, Pugh JR (2019). Mechanisms of GABAB receptor enhancement of extrasynaptic GABAA receptor currents in cerebellar granule cells. Sci Rep. 9(1):16683. doi: 10.1038/s41598-019-53087-4.
Khatri SN, Wu WC, Yang Y, Pugh JR (2019). Direction of action of presynaptic GABAA receptors is highly dependent on the level of receptor activation. J Neurophysiol. 121(5):1896-1905. doi: 10.1152/jn.00779.2018.
EK Lucas, WC Wu, C Roman-Ortiz and RL Clem (2019). Prazosin during fear conditioning facilitates subsequent extinction in male C57Bl/6N mice. Psychopharmacology. 236(1):273-279. doi: 10.1007/s00213-018-5001-x.
Arruda-Carvalho, M., Wu, WC., Cummings, KA. and Clem, RL. (2017) Optogenetic examination of prefrontal-amygdala synaptic development J Neurosci. Mar 15;37(11):2976-2985 doi: 10.1523/JNEUROSCI.3097-16.2017. Epub 2017 Feb 13