Cellular and Integrative Physiology

Yansheng Feng, Ph.D.

Postdoctoral Fellow

Personal Statement:

Lab Affiliation:
Jean C. Bopassa, Ph.D

Professional Experience:

2015.4- now                            Postdoctoral fellow in cardiovascular Department of Cellular and Integrative Physiology, University of Texas Health Science Center at San Antonio

2012.9-2105.4                         Research Fellow in cardiovascularThe Department of Pathophysiology, Xinxiang Medical University, Xinxiang, Henan, China


2008.9-2012.6 Ph.D. program in Molecular biology of cardiovascular
The Department of Pathophysiology, Xiangya School of
Medicine, Central South University of China, Changsha,
Hunan, China

2005.9-2008.6 M.S. in Inflammation and septic shock
The Department of Pathophysiology, Xiangya School of
Medicine, Central South University of China, Changsha,
Hunan, China

2000.9-2005.7 B.S. in Clinical medicine
Xinxiang Medical University, Xinxiang, Henan, China



Madungwe NB, Feng Y, Lie M, Tombo N, Liu L, Kaya F, Bopassa JC. Mitochondrial Inner Membrane Protein (Mitofilin) Knockdown Induces Cell Death by Apoptosis Via an AIF-PARP-Dependent Mechanism and Cell Cycle Arrest. Am J Physiol Cell Physiol. 2018 (Accepted, Co first author)

Jiang L, Wang H, Chen G, Feng Y, Zou J, Liu M, Liu K, Wang N, Zhang H, Wang K, Xiao X. WDR26/MIP2 interacts with VDAC1 and regulates VDAC1 expression levels in H9c2 cells. Free Radic Biol Med. 2017 Dec 15;117:58-65.

Feng Y, Madungwe NB, da Cruz Junho CV, Bopassa JC. Activation of G protein-coupled oestrogen receptor 1 at the onset of reperfusion protects the myocardium against ischemia/reperfusion injury by reducing mitochondrial dysfunction and mitophagy. Br J Pharmacol. 2017 Dec;174(23):4329-4344.

Feng Y, Zhao J, Hou H, Zhang H, Jiao Y, Wang J, Wang Y, Sun Y. WDR26 promotes mitophagy of cardiomyocytes induced by hypoxia through Parkin translocation. Acta Biochim Biophys Sin. 2016 Dec;48(12):1075-1084.

Madungwe NB, Zilberstein NF, Feng Y, Bopassa JC. Critical role of mitochondrial ROS is dependent on their site of production on the electron transport chain in ischemic heart. Am J Cardiovasc Dis. 2016 Sep 15;6(3):93-108.

Zhang C, Qu S, Wei X, Feng Y, Zhu H, Deng J, Wang K, Liu K, Liu M, Zhang H, Xiao X. HSP25 down-regulation enhanced p53 acetylation by dissociation of SIRT1 from p53 in doxorubicin-induced H9c2 cell apoptosis. Cell Stress Chaperones. 2016 Mar;21(2):251-60.

Feng Y, Bopassa JC. Oxygen surrounding the heart during ischemic conservation determines the myocardial injury during reperfusion. Am J Cardiovasc Dis. 2015 Aug 1;5(2):127-39.

Bao Y, Chen Z, Guo Y, Feng Y, Li Z, Han W, Wang J, Zhao W, Jiao Y, Li K, Wang Q, Wang J, Zhang H, Wang L, Yang W. Tumor suppressor microRNA-27a in colorectal carcinogenesis and progression by targeting SGPP1 and Smad2. PLoS One. 2014 Aug 28;9(8):e105991.

Feng Y, Zhang C, Luo Q, Wei X, Jiang B, Zhu H, Zhang L, Jiang L, Liu M, Xiao X. A novel WD-repeat protein, WDR26, inhibits apoptosis of cardiomyocytes induced by oxidative stress. Free Radic Res. 2012 Jun;46(6):777-84.

Zhu H, Wei X, Qu S, Zhang C, Zuo X, Feng Y, Luo Q, Chen G, Liu M, Jiang L, Xiao X, Wang K. Ischemic postconditioning protects cardiomyocytes against ischemia/reperfusion injury by inducing MIP2. Exp Mol Med. 2011 Aug 31;43(8):437-45.

Luo Q, Jiang L, Chen G, Feng Y, Lv Q, Zhang C, Qu S, Zhu H, Zhou B, Xiao X. Constitutive heat shock protein 70 interacts with α-enolase and protects cardiomyocytes against oxidative stress. Free Radic Res. 2011 Nov;45(11-12):1355-65.

Zhang C, Feng Y, Qu S, Wei X, Zhu H, Luo Q, Liu M, Chen G, Xiao X. Resveratrol attenuates doxorubicin-induced cardiomyocyte apoptosis in mice through SIRT1-mediated deacetylation of p53. Cardiovasc Res. 2011 Jun 1;90(3):538-45.

Song L, Zhang B, Feng Y, Luo X, Wei X, Xiao X. A role for forkhead box A1 in acute lung injury. Inflammation. 2009 Oct;32(5):322-32.

Song L, Wei X, Zhang B, Luo X, Liu J, Feng Y, Xiao X. Role of Foxa1 in regulation of bcl2 expression during oxidative-stress-induced apoptosis in A549 type II pneumocytes. Cell Stress Chaperones. 2009 Jul;14(4):417-25.

Feng Y, Liu M, Liu Y, Liu J, ChenG, Zhang H, Xiao X. Role of Kruppel-like factor 4 in regulating the expression of IL-6 induced by LPS. Prog. Biochem. Biophys 2009, 36, 1313-1318

Liu J, Zhang H, Liu Y, Wang K, Feng Y, Liu M, Xiao X. KLF4 regulates the expression of interleukin-10 in RAW264.7 macrophages.Biochem Biophys Res Commun. 2007 Oct 26;362(3):575-81.



Madungwe NB, Feng Y, M Lie, CV da Cruz Junho, JC Bopassa.Role of the Interaction Cyclophilin D-MPV17 in the Inner Membrane of Mitochondria in Cardiac Ischemia/Reperfusion Injury. Circulation 136 (Suppl 1), A20896-A20896.

2. Bopassa JC, Madungwe NB, Feng Y, Lie M. Mitofilin Knockdown Induces Cell Death by Apoptosis via an AIF-PARP-dependent Mechanism and Cell Cycle Arrest. Circulation Research 121 (Suppl 1), A206-A206

Feng Y, Lie M, Madungwe NB, Kabir ME, Bopassa JC. Activation of GPER1 at the Reperfusion Protects the Ischemic Myocardium Against Injury by Decreasing Mitophagy and Delaying the mPTP Opening. Circulation 134 (Suppl 1), A19034-A19034

Feng Y, Madungwe NB, Kabir ME, Bopassa JC. Post-ischemic Estrogen Administration Protects the Myocardium Against Ischemia Reperfusion Injury by Reducing Mitochondrial Protein Ubiquitination, Acetylation and Calpain10 Levels and Inhibition of the mPTP Opening via GPER1 Activation. Circulation Research 119 (Suppl 1), A115-A115