{"id":380,"date":"2018-11-21T15:18:50","date_gmt":"2018-11-21T15:18:50","guid":{"rendered":"https:\/\/wp.uthscsa.edu\/ophthalmology\/?page_id=380"},"modified":"2018-11-21T15:18:50","modified_gmt":"2018-11-21T15:18:50","slug":"vascular-physiology-laboratory","status":"publish","type":"page","link":"https:\/\/lsom.uthscsa.edu\/stage-ophthalmology\/research\/vascular-physiology-laboratory\/","title":{"rendered":"Vascular Physiology Laboratory"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row][vc_column width=&#8221;2\/3&#8243;][vc_column_text]<span style=\"font-weight: 400\">Elevated intraocular pressure (IOP), is the most significant risk factor for glaucoma, and IOP reduction remains the primary goal of glaucoma treatment. \u00a0The steady state IOP is set by aqueous production and outflow, and it is our knowledge of aqueous dynamics that provides a rational basis for understanding high IOP and the various treatments used to manipulate IOP. <\/span><\/p>\n<p><span style=\"font-weight: 400\">The goal of our research is to address a fundamental gap in our knowledge of aqueous dynamics: the role of ciliary blood flow in aqueous production. \u00a0We are currently testing the hypothesis that a critical level of ciliary blood flow exists for a given level of secretory stimulation, and that aqueous production is blood flow independent until blood flow is reduced below that critical level. Our specific aims are to quantify the interrelationships between ciliary blood flow, metabolism, and aqueous production over a wide range of perfusion pressures under control conditions and after administration of drugs expected to alter aqueous production or ciliary blood flow, or both. \u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400\">Our experiments are performed in anesthetized animals instrumented with hydraulic occluders on the inferior vena cava and aorta to control mean arterial pressure (MAP) which is measured via an arterial cannula. \u00a0The eye is cannulated to measure IOP. Ciliary blood flow is measured by laser Doppler flowmetry using a fiber optic probe placed on the sclera over the ciliary body. Ciliary metabolism is estimated from ciliary PO2 measurements. \u00a0Episcleral and anterior uveal venous pressures are measured by the servonull technique. Aqueous production is measured by fluorophotometry. <\/span><\/p>\n<p><span style=\"font-weight: 400\">A typical experiment entails changing ciliary blood flow by holding the MAP at different levels above and below baseline for 60-90 min to obtain steady state measurements. We have already established the normal relationships between the measured variables, and are now looking at conditions of drug-induced secretory stimulation and inhibition, and ciliary vasodilation and vasoconstriction. \u00a0Plotting the aqueous flow as a function of ciliary blood flow indicates which drugs alter aqueous production directly at the cellular level, those that affect production indirectly due to their vascular effects, and those that affect production directly and indirectly. This information will further our understanding of the physiology of aqueous dynamics and the pharmacology of drugs used in the treatment of glaucoma, and will also be used to continue the development of a comprehensive mathematical model of ocular hydrodynamics.<\/span>[\/vc_column_text][\/vc_column][vc_column width=&#8221;1\/3&#8243;][vc_column_text]<b>For more information, please contact:<\/b><br \/>\nJeffrey W. Kiel, Ph.D.<br \/>\nProfessor \/ Director of the Vascular Physiology Lab<br \/>\nUT San Antonio<br \/>\n7703 Floyd Curl Drive, MC 6230<br \/>\nSan Antonio, TX 78229-3900<br \/>\nPhone: 210-567-8474<br \/>\nFax: 210-567-8413<br \/>\n[\/vc_column_text][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column width=&#8221;2\/3&#8243;][vc_column_text]Elevated intraocular pressure (IOP), is the most significant risk factor for glaucoma, and IOP reduction remains the primary goal of glaucoma treatment. \u00a0The steady state IOP is set by aqueous production and outflow, and it is our knowledge of aqueous dynamics that provides a rational basis for understanding high IOP and the various treatments [&hellip;]<\/p>\n","protected":false},"author":161,"featured_media":0,"parent":15,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"page-templates\/child-page.php","meta":{"footnotes":""},"class_list":["post-380","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - 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