Dr. Teresa Johnson-Pais obtained her Ph.D. degree at the UT Health San Antonio, TX. She subsequently trained at the Oregon Health Sciences University, Portland, OR as a post-doctoral fellow in the laboratory of Mathew J. Thayer, Ph.D. Dr. Johnson-Pais is the authored or co-author of 50 publications. She is co-Director of the institutional Biobanking and Genome Analysis Core Laboratory and the Cancer Therapy and Research Center Genomics Shared Resource. She lectures in courses for the graduate program in Integrated Biomedical Sciences and is a course director for the Masters in Clinical Investigation graduate program.
Ph.D., UT Health San Antonio (1994)
BS, University of Nebraska (1986)
With the use of genomic microarrays covering the 18q21-18q23 region, Dr. Teresa Johnson-Pais’s lab has performed array comparative genomic hybridization (array CGH) experiments using prostate cancer specimens and have identified a copy number gain at 18q22.1. This region includes the gene for cadherin 7.
The cadherins are a superfamily of transmembrane glycoproteins that mediate cellular adhesion. We are developing a transgenic mouse that overexpresses cadherin-7 to determine the role that increased copies of this gene plays in prostate cancer progression.
We are also investigating the homozygous loss of sequences at 18q detected by array CGH in 58 percent of prostate tumors and 70 percent of breast tumors. We have identified a novel transcript that is encoded in this region of loss and are in the process of characterizing this transcript.