Guolan Xiao, Ph.D.

Postdoctoral Fellow

Personal Statement:

I am a postdoctoral researcher working under the guidance of Dr. Hong-yu Li at UTHSCSA. My research is focused on the discovery and development of chemical compounds for catalytic degradation of targeted Proteins. Our strategies include proteolysis targeting chimera (PROTAC) and lysosome-targeting chimaeras (LYTAC). They can effectively degrade targets that are “undruggable” for traditional small molecule inhibitors, greatly expanding the potential of therapies for tumors and other refractory diseases.

Education

Postdoctoral Fellowship - Shanghai Jiao Tong University, Shanghai, China
Ph.D., M.S. - East China Normal University, Shanghai, China
B.S. - South China Normal University, Guangdong, China

Research

Drug discovery

Proteolysis targeting chimera

Targeted protein degradation

Lysosome-targeting chimaeras

Organic chemistry

Medicinal chemistry

Publications

Enantioselective Synthesis of α‑Mercapto-β-amino Esters via Rh(II)/Chiral Phosphoric Acid-Cocatalyzed Three-Component Reaction of Diazo Compounds, Thiols, and Imines. Org. Lett. 2016, 18, 6086. (First author)

Synthesis of γ‑Sulfur-Substituted Ketones via Rh(II)/Sc(III) a Cocatalyzed Three-Component Reaction of Diazo Compounds with Thiophenols and Enones. J. Org. Chem. 2018, 83, 4786. (First author)

Rh(II)/Chiral Phosphoric Acid-Cocatalyzed Enantioselective Synthesis of Spirooxindole-Fused Thiaindans. Org. Lett. 2018, 20, 4531. (First author)

A Cleavage-Modification-Reassembly Process Catalyzed by Rhodium and Brønsted Acid for the Synthesis of Multi-Substituted Anilines. Adv. Synth. Catal. 2020, 362, 1961. (co-first author）

Palladium-catalyzed C–H olefination of uridine, deoxyuridine, uridine monophosphate and uridine analogues RSC Adv., 2022,12, 24930. (co-author). Handbook of CH-Functionalization, 2022, 1-65 doi:10.1002/9783527834242.chf0217. (co-author)