Daniel Lodge, Ph.D.
Professor of Pharmacology
In a broad sense, my laboratory is interested in better understanding the mechanisms underlying psychiatric disease with the goal of developing novel therapeutic approaches. To do this we utilize a number of different approaches including optogenetics, in vivo electrophysiology, behavioral and molecular methods. Using such an approach, we have identified what we believe to be a key pathology in schizophrenia, specifically a loss of interneuron function in the ventral hippocampus. This has led to a hypothesis that restoring interneuron function may be a novel therapeutic approach for schizophrenia. Specifically, we are currently investigating the utility of stem cell derived interneuron transplants in rodent models of schizophrenia and autism.
This figure depicts transplanted inhibitory neurons in the ventral hippocampus. These transplanted neurons were sufficient to reverse aberrant neurophysiology and behavior in a rodent model of schizophrenia.
|• dopamine||• hippocampus|
|• schizophrenia||• drug abuse|
|• electrophysiology||• neuroscience|
- Aguilar, DD., Chen, L. and Lodge, DJ. (2014) Increasing Endocannabinoid Levels in the Ventral Pallidum Restore Aberrant Dopamine Neuron Activity in the Subchronic PCP Rodent Model of Schizophrenia. Int J Neuropsychopharmacol Oct 31;18(1). pii: pyu035
- Chen, L., Perez, SM. and Lodge, DJ. (2014) An augmented dopamine system function is present prior to puberty in the methylazoxymethanol acetate rodent model of schizophrenia. Developmental Neurobiology Sep;74(9):907-917
- Perez, SM., Chen, L. and Lodge, DJ. (2014) Alterations in dopamine system function across the estrous cycle of the MAM rodent model of schizophrenia. Psychoneuroendocrinology Sep;47:88-97
- Boley, AM., Perez, SM. and Lodge, DJ. (2014) A fundamental role for hippocampal parvalbumin in the dopamine hyperfunction associated with schizophrenia. Schizophr Res Aug;157(1-3):238-43
- Perez, SM., Carreno, FR., Frazer, A. and Lodge, DJ. (2014) Vagal nerve stimulation reverses aberrant dopamine system function in the methylazoxymethanol acetate rodent model of schizophrenia. J Neurosci Jul 9;34(28):9261-7