Paul ‘Anthony’ Martinez
Postdoctoral Fellow
Personal Statement:
Mitochondrial dysfunction, oxidative stress, and environmental exposure have been linked to Parkinson’s disease. Anthony is investigating underlying mechanisms by which exposure to pesticides lead to increased aldehyde accumulation as a result of mitochondrial dysfunction. Using mice with variable expression of aldehyde dehydrogenase isozymes found in nigrostriatal dopamine neurons, he is also evaluating the tendency these isozymes to promote alpha-synuclein oligomerization, as well as to investigate differences in sensitivity to pesticides.
Hometown
Center Point, Texas
Lab Association
Randy Strong, Ph.D.
Hobbies and Interests
Jogging, Weight Lifting, Biking, Boxing, Music, Camping, and Barbecuing.
Education
BS, Biochemistry
Angelo State University - San Angelo, Texas
Awards & Accomplishments
Received the Congressman Henry Bonilla Health Professions Scholarship – 2012
Received the Sjoerd Steunebrink Scholarship – 2012
Affiliations
Wey MC, Fernandez E, Martinez PA, Sullivan P, Goldstein DS, Strong R (2012) Neurodegeneration and motor dysfunction in mice lacking cytosolic and mitochondrial aldehyde dehydrogenases: Implications for Parkinson’s Disease. PLoS One 7(2):e31522. doi:10.1371/journal.pone.0031522
Green MK, Rani SS, Joshi A, Soto-Pina AE, Martinez PA, Frazer A, Strong R, Morilak DA (2011) Prenatal stress induces long term stress vulnerability, compromising stress response systems in the brain and impairing extinction of conditioned fear after adult stress. Neuroscience 192:438-451.
News
11th Annual Center for Biomedical Neuroscience Conference – San Antonio, TX – Spring 2013
Cognitive impairment precedes age-related motor deficits in the MitoPark mouse model of Parkinson’s Disease (Poster)
2013 Arlan Richardon Student Research Symposium – San Antonio, TX – Spring 2013
Cognitive impairment precedes age-related motor deficits in the MitoPark mouse model of Parkinson’s Disease (Poster)
San Antonio Nathan Shock Aging Center 2012 Conference on Aging – Bandera, TX – Fall 2012
Impaired locomotor function in Aldh1a1 and GPX1 deficient mice (Poster)
19th Annual UTHSCSA Pharmacology Graduate Student Symposium – San Antonio, TX – Fall 2012
Impaired locomotor function in Aldh1a1 and GPX1 deficient mice (Poster)
Publications
Song C, Zhang J, Qi S, Liu Z, Zhang X, Zheng Y, Andersen JP, Zhang W, Strong R,
Martinez PA, Musi N, Nie J, Shi Y (2019) Cardiolipin remodeling by ALCAT1 links mitochondrial dysfunction to Parkinson’s disease. Aging Cell e12941. Doi:10.1111/acel.12941
Bai X, Wey MC, Martinez PA, Shi C, Fernandez E, Strong R (2017) Neurochemical and
motor changes in mice with combined mutations linked to Parkinson’s disease.
Pathobiol Aging Age Relat Dis 7(1)1267855. doi: 10.1080/20010001.2017.1267855
Strong R, Miller RA, Antebi A, Astle CM, Bogue M, Denzel MS, Fernandez E, Flurkey K,
Hamilton KL, Lamming DW, Javors MA, Pedro de Magalhaes J,Martinez PA, McCord JM, Miller BF, Muller M, Nelson JF, Ndukum J, Rainger GE, Richardson A, Sabatini DM, Salmon AB, Simpkins JW, Steegenga WT, Nadon NL, Harrison DE (2016) Longer lifespan in male mice treated with a weakly-estrogenic agonist, an antioxidant, an a-glucosidase inhibitor or a Nrf2-inducer. Aging Cell doi:10.111/acel12496
Xiuhua L, Redus L, Chen C, Martinez PA, Strong R, Li S, O’Connor JC (2013) Cognitive
dysfunction precedes the onset of motor symptoms in the Mitopark mouse model of Parkinson’s disease. PLoS One 8(8):e71341. doi:101371/journal.pone.0071341
Wey MC, Fernandez E, Martinez PA, Sullivan P, Goldstein DS, Strong R (2012)
Neurodegeneration and motor dysfunction in mice lacking cytosolic and mitochondrial aldehyde dehydrogenases: Implications for Parkinson’s Disease. PLoS One 7(2):e31522. doi:10.1371/journal.pone.0031522
Green MK, Rani SS, Joshi A, Soto-Pina AE, Martinez PA, Frazer A, Strong R, Morilak
DA (2011) Prenatal stress induces long term stress vulnerability, compromising stress response systems in the brain and impairing extinction of conditioned fear after adult stress. Neuroscience 192:438-451.