Qiu Li, Ph.D.
Postdoctoral Fellow
Personal Statement:
I am a postdoctoral researcher working under the guidance of Dr. Hong-yu Li at UTHSCSA. Our research is focused on medicinal chemistry especially in the field of the small molecule inhibitors, agonists, or degraders driven by structure-based drug design for the treatment of cancer or aging.
Education
2022 - Ph.D., University of Chinese Academy of Sciences, Chinese Academy of Sciences, China
2018 - Masters Degree, Southern Medical University, China
2015 - Bachelor Degree, Guangdong Medical University, China
Research
| Pharmacology
Structure-based drug design |
Nonalcoholic fatty liver disease |
| Cancer | Aging |
Awards & Accomplishments
Outstanding postgraduate scholarship (2021, 2022)
Merit student of UCAS (2021, 2022)
First-class scholarship of UCAS (2020)
Outstanding postgraduate of Southern Medical University (2018)
National scholarship for postgraduates (2017)
Excellent student leader of Southern Medical University (2017)
First-class scholarship of Southern Medical University (2016, 2017)
Excellent graduation thesis of Guangdong Medical University (2015)
Publications
Qiu Li, Benqiang Yao, Shiting Zhao, Zhou Lu, Yan Zhang, Qiuping Xiang, Xishan Wu, Haonan Yu, Cheng Zhang, Junhua Li, Xiaoxi Zhuang, Donghai Wu, Yong Li, Yong Xu. Discovery of a highly selective and H435R sensitive thyroid hormone receptor β agonist. Journal of Medicinal Chemistry 2022, 65, 7193-7211.
Qiu Li, Lin Chen, Yufeng Ma, Xieer Jian, Jiahao Ji, Wenwei You, Peiliang Zhao. Development of pteridin-7(8H)-one analogues as highly potent cyclin-dependent kinase 4/6 inhibitors: Synthesis, structure-activity relationship, and biological activity. Bioorganic Chemistry 2021, 116, No. 105324.
Qiu Li, Lin Chen, Xieer Jian, Dongxin Lv, Wenwei You, Peiliang Zhao. Design, synthesis and antiproliferative activity of novel 2,4-diamino-5- methyleneaminopyrimidine derivatives as potential anticancer agents. Bioorganic & Medicinal Chemistry Letters 2021, 47, No. 128213.
Qiu Li, Xieer Jian, Yufeng Ma, Lin Chen, Xiansen Huo, Yu Wang, Renxin He, Wenwei You, Peiliang Zhao. Synthesis and antiproliferative evaluation of novel 8-cyclopentyl-7,8-dihydropteridin-6(5H)-one derivatives as potential anticancer agents. Bioorganic & Medicinal Chemistry Letters 2021, 31, No. 127684.
Qiu Li, Xieer Jian, Zhiru Chen, Lin Chen, Xiansen Huo, Zihua Li, Wenwei You, Jinjun Rao, Peiliang Zhao. Synthesis and biological evaluation of benzofuran-based 3,4,5-trimethoxybenzamide derivatives as novel tubulin polymerization inhibitors. Bioorganic Chemistry 2020, 102, No. 104076.
Qiu Li, Peng Chen, Haikui Yang, Miaolan Luo, Wenwei You, Peiliang Zhao. Synthesis, antiproliferative evaluation, and structure–activity relationships of novel triazole–isoindoline hybrids bearing 3,4,5-trimethoxyphenyl moiety. Chemical Papers 2018, 72, 651–659.
Qiu Li, Haikui Yang, Qi Sun, Wenwei You, Peiliang Zhao. Design, synthesis and antiproliferative activity of novel substituted 2-amino-7,8-dihydropteridin- 6(5H)-one derivatives. Bioorganic & Medicinal Chemistry Letters 2017, 27, 3954-3958.
Pengcheng Diao, Qiu Li, Mengjin Hu, Yufeng Ma, Wenwei You, Kwonho Hong, Peiliang Zhao. Synthesis and biological evaluation of novel indole-pyrimidine hybrids bearing morpholine and thiomorpholine moieties. European Journal of Medicinal Chemistry 2017, 134, 110-118.
Qiu Li, Yu Wang, Mengjin Hu，Peng Chen，Wenwei You，Peiliang Zhao. Synthesis and biological evaluation of novel 2,4-diaminopyrimidine derivatives bearing indole moiety. Chinese Journal of Organic Chemistry 2017, 37, 967-974.