Sangeetha Subramani, Ph.D.
Postdoctoral Fellow
Personal Statement:
I am a postdoctoral research fellow working under Professor Hong-yu Li at UTHSCSA. Our research is synthesizing novel PROTACs for protein degradation to develop a drug for cancer.
Education
Postdoctoral Research Associate, 2022-2023, College of Pharmacy, University of Arkansas for Medical Sciences
Postdoctoral Research Associate, 2021-2022, Department of Chemistry, the University of Texas at San Antonio
Postdoctoral Research Associate, 2019-2021, School of Pharmacy, University of Pittsburgh
Ph.D. in Chemistry, 2014-2019, Department of Chemistry, IIT Madras, Chennai, India
Research
| I am interested in organic synthesis such as synthetic methodology and small molecule synthesis in medicinal chemistry. Currently, I am working on proteolysis targeting chimeras synthesis and their activity in cancer cells.
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Awards & Accomplishments
2019: Thesis Award: Professor Ramamurthy Endowment Prize for Best Ph.D.
2014-2019: Merit based fellowship (HTRA) for doctoral program, IIT Madras
Publications
S. Sangeetha, P. Muthupandi, and G. Sekar. Copper-Catalyzed Domino Synthesis of 2- Arylthiochromanones through Concomitant C−S Bond Formations Using Xanthate as Sulfur Source. Org. Lett. 2015, 17, 6006-6009 (highlighted in Organic ChemistryPortal).
S. Sangeetha and G. Sekar. Copper-Catalyzed One-Pot Synthesis of 2- Arylthiochromenones: An In Situ Recycle of Waste By-product as Useful Reagent. Org. Lett. 2019, 21, 75-79.
S. Sangeetha and G. Sekar. Synthesis of 2-Acylbenzo[b]thiophenes via Cu-Catalyzed α- C−H Functionalization of 2-Halochalcones Using Xanthate. Org. Lett. 2017, 19, 1670- 1673 (highlighted in Organic Chemistry Portal).
S. Sangeetha and G. Sekar. Copper-catalyzed double C–S bond formation for the synthesis of 2-acyldihydrobenzo[b]thiophenes and 2-acylbenzo[b]thiophenes. Chem. Commun. 2020, 56, 10906-10909.
S. Sangeetha, P. Soundarya and G. Sekar. Cu-Nanoparticles catalyzed synthesis of 2- arylthiochromanones using xanthate sulfur. (IN Patent 415,562).
N. Sundaravelu,A S. Sangeetha and G. Sekar. Metal-catalyzed C-S bond formation using sulfur surrogates. Org. Biomol. Chem. 2021, 19, 1459-1482 (aAuthors are equally contributed).
A. Muthukumar, S. Sangeetha and G. Sekar. Recent developments in functionalization of acyclic α-keto amides. Org. Biomol. Chem. 2018, 16, 7068-7083.
S. Chandrasekar, S. Sangeetha and G. Sekar. Synthesis of 1,3-disubstituted imidazo[1,5- a]pyridines through oxidative C-N bond formation from aryl-2- pyridylmethanols and their fluorescent study. ChemistrySelect 2019, 4, 5651-5655.
S. Sowndarya, S. Sangeetha, J. Sridevi, S. Preethi, Y. Arun and C. Rose. Bioactive compound 1,8-Cineole selectively induces G2/M arrest in A431 cells through the upregulation of the p53 signalling pathway and molecular docking studies. Phytomedicine. 2018, 46, 57–68.