Contact
- (210) 567-0106
- hiranita@uthscsa.edu
Department
PharmacologyTakato Hiranita
Associate Professor/Research
Personal Statement:
I earned a B.S. degree in the Department of Pharmaceutical Sciences (Molecular Bioformatics) from Kyushu University, and a Ph.D. in the Department of Pharmacology (Pharmaceutical Sciences, Drs. Tsuneyuki Yamamoto and Kazuhide Inoue) from the Graduate School of Pharmaceutical Sciences, Kyushu University. I have joined the laboratory of Dr. Jonathan L. Katz at the National Institute on Drug Abuse (NIDA), National Institutes of Health (NIH), as a postdoctoral research fellow. I was a Staff Fellow in the Division of Neurotoxicology, National Center for Toxicological Research (NCTR), Food and Drug Administration (FDA), where he was the head of a rodent behavioral and neurochemical pharmacology lab. I was the principal investigator for studies from the Center for Tobacco Products and Drug Enforcement Administration. Thereafter, I joined the University of Florida College of Pharmacy as a research assistant professor in the Department of Pharmacodynamics and the Texas Tech University Health Sciences Center, Jerry H. Hodge School of Pharmacy, as a research assistant professor in the Department of Pharmaceutical Sciences (Dr. Lance R. McMahon’s lab). Currently, I am a Research Associate Professor in the Department of Pharmacology (Dr. Charles P. France’s lab), University of Texas Health San Antonio. My research interest is preclinical abuse potential and efficacy assessments of novel compounds as medications for drug abuse using intravenous drug self-administration procedures.
Education
Bachelor of Science from Kyushu University
Ph.D. in the Department of Pharmacology (Pharmaceutical Sciences, Drs. Tsuneyuki Yamamoto and Kazuhide Inoue) from the Graduate School of Pharmaceutical Sciences, Kyushu University
Publications
Novel Approaches, Drug Candidates, and Targets in Pain Drug Discovery.
Obeng S, Hiranita T, León F, McMahon LR, McCurdy CR.
J Med Chem. 2021 May 27;64(10):6523-6548. doi: 10.1021/acs.jmedchem.1c00028. Epub 2021 May 6. PMID: 33956427 Review.
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Activity of Mitragyna speciosa (“Kratom”) Alkaloids at Serotonin Receptors. |
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The discriminative stimulus effects of epibatidine in C57BL/6J mice. |
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Effects of benztropine analogs on delay discounting in rats. |
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The use of hypercapnic conditions to assess opioid-induced respiratory depression in rats. |
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Correction to “Novel Approaches, Drug Candidates, and Targets in Pain Drug Discovery”. |
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In vitro and in vivo pharmacology of kratom. |
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Exploring the Chemistry of Alkaloids from Malaysian Mitragyna speciosa (Kratom) and the Role of Oxindoles on Human Opioid Receptors. |
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Pharmacological Comparison of Mitragynine and 7-Hydroxymitragynine: In Vitro Affinity and Efficacy for μ-Opioid Receptor and Opioid-Like Behavioral Effects in Rats. |
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The effects of mitragynine and morphine on schedule-controlled responding and antinociception in rats. |
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Investigation of the Adrenergic and Opioid Binding Affinities, Metabolic Stability, Plasma Protein Binding Properties, and Functional Effects of Selected Indole-Based Kratom Alkaloids. |
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Evaluation of the rewarding effects of mitragynine and 7-hydroxymitragynine in an intracranial self-stimulation procedure in male and female rats. |
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The Lack of Contribution of 7-Hydroxymitragynine to the Antinociceptive Effects of Mitragynine in Mice: A Pharmacokinetic and Pharmacodynamic Study. |
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Cannabimimetic effects of abused indazole-carboxamide synthetic cannabinoid receptor agonists AB-PINACA, 5F-AB-PINACA and 5F-ADB-PINACA in mice: Tolerance, dependence and withdrawal. |