Contact

Department

Medicine/Division of Geriatrics, Gerontology, and Palliative Medicine; Cellular and Integrative Physiology

Dean L. Jr. Kellogg, M.D., Ph.D.

Professor

Personal Statement:

Dean L. Kellogg, Jr., MD, Ph.D., is a tenured Professor in the Departments of Medicine/Division of Geriatrics, Gerontology, and Palliative Medicine and also in Cellular and Integrative Physiology at the University of Texas Health Science Center-San Antonio and a member of the Barshop Institute for Longevity and Aging Studies.  He is a staff physician at the Geriatric Research, Education, and Clinical Center and Spinal Cord Injury Center at the South Texas Veterans Health Care System (STVHCS) and is involved in direct clinical care of Veterans including the “Former Prisoner of War (FPOW) Clinic”, a quality improvement project.  Dr. Kellogg’s principal research efforts are directed toward amelioration of the aging process in humans through translational clinical trials with age-modulating and immuno-modulating pharmacological agents. These projects involve exploring the effects of rapamycin and other senotherapeutics on mechanisms of neurovascular function, changes in oxidative stress levels, and altered protein expression in older human subjects using minimally invasive techniques. Dr. Kellogg is also studies to into physiological mechanisms of thermoregulatory and vasomotor controls in spinal cord injured persons. continue to provide primary care service at the VA and serve on 2 NIH committees.  Finally, Dr. Kellogg is a researcher/staff physician at the Geriatric Research, Education, and Clinical Center and Spinal Cord Injury Center at the South Texas Veterans Health Care System (STVHCS) and is involved in direct clinical care of Veterans including the “Former Prisoner of War (FPOW) Clinic”, a quality improvement project and the Spinal Cord Injury Unit.

Awards & Accomplishments

Grant Support

Title:  A Proof of Concept Study of Cutaneous Pressure Induced Vasodilation Alteration in Persons with Spinal Cord Injury; Implication for Pressure Ulcers
Major Goals:  We will determine whether pressure induced vasodilation is altered in spinal cord injured veterans.
Name of PD/PI: MPI: Michelle Trbovich, Dean L Kellogg, Jr.
Source of Support: Paralyzed Veterans Association
Primary Place of Performance:  Audie L. Murphy Memorial Veterans’ Hospital, 7400 Merton Minter Boulevard, San Antonio, TX 78229-4404

 

Title: Pathophysiological mechanisms of PASC: Inflammatory mediators of endothelial dysfunction in the RECOVER cohort
Major Goals: Our aim is to define endothelial dysfunction in PASC patients and to explore the pathophysiological mechanisms involved PASC (Post Acute Sequelae of SARS-CoV-2).
Name of PD/PI:  Ellen Kraig (contact MPI), MPI: Dean Kellogg Jr., Tom Patterson, Doug Seals
Source of Support: NIH/NHLBI (passed through NYU RECOVER project)
Primary Place of Performance: UT Health San Antonio, 7703 Floyd Curl, San Antonio, TX 78229

 

Title: San Antonio Claude D. Pepper Older Americans Independence Center
Major Goals: The purpose of this core is to provide leadership and develop an infrastructure that fosters integration of aging-related basic and clinical sciences, catalyzes scientific discoveries, promotes education and mentorship, and partners with other scientists and the community at large, with the overarching goal of developing novel interventions to improve the health, quality of life, and independence of older Americans.
Name of PD/PI: Elena Volpi (Core: Elena Volpi)
Source of Support: NIH/NIA
Primary Place of Performance: University of Texas Health Science Center at San Antonio

 

Title:  eRAPA for Bladder Cancer Prevention
Major Goals: Our aim is to test whether eRAPA prevents recurrence of bladder cancer and also improves physical and cognitive function in bladder cancer patients.
Name of PD/PI:  Robert Svatek; Co-I: Dean L. Kellogg, Jr.
Source of Support: NIH/NCI
Primary Place of Performance:  UT Health San Antonio, 7703 Floyd Curl, San Antonio, TX 78229

 

Title:  An innovative proof-of-concept approach to identify age-modulating drugs capable of reversing inflammation and re-setting the epigenetic clock
Major Goals: This grant tests the use of topical application of potential anti-aging intervention to elicit effects at the site of delivery that correlate with parameters of aging. Rapamycin was used to test this approach to non-invasive human subject trials.
Name of PD/PI:  MPI: Ellen Kraig (contact) and Dean L. Kellogg, Jr.
Source of Support: NIH/NIA
Primary Place of Performance: UTHSCSA, 7703 Floyd Curl Drive, San Antonio, TX 78229

 

Title:  Phase 2 Trial of Rapamycin for Alzheimer’s Disease
Major Goals:  We will determine the effects of rapamycin on cognition in early Alzheimer’s disease patients.
Name of PD/PI: Sudha Seshadri; Co-I: Dean L. Kellogg, Jr.
Source of Support: Alzheimer’s Association Part of the Cloud – Gates
Primary Place of Performance:  UT Health San Antonio, 7703 Floyd Curl, San Antonio, TX 78229

 

Title:  Passive heating as an accessible and tolerable strategy to improve the inflammatory profile and cardiometabolic health in people with spinal cord injury
Major Goals:  We will determine whether repeated bouts of whole body heating reduce chronic inflammation in spinal cord injured veterans.
Name of PD/PI: Michelle Trbovich; Co-I: Dean L. Kellogg, Jr.
Source of Support: Veteran Administration
Primary Place of Performance:  Audie L. Murphy Memorial Veterans’ Hospital, 7400 Merton Minter Boulevard, San Antonio, TX 78229-4404

Affiliations

Positions and Employment

2016-present      Staff Physician, Spinal Cord Injury Clinic, South Texas Veterans HC System

2015-present      Clinical Research Core Co-Director, Claude D. Pepper OAIC, UTHSCSA

2010-present      Director, Former Prisoner of War Clinic, STVHCS

2007-present      Professor, Department of Medicine, Division of Geriatrics & Gerontology, UTHSCSA

2007-present      Professor, Department of Physiology, UTHSCSA

2014-2016          Director, Geriatric Evaluation and Management Clinic, South Texas Veterans HC System

2001-2007          Associate Professor, Department of Physiology, UTHSCSA

2001-2007          Associate Professor, Department of Medicine, UTHSCSA

1994-2001          Assistant Professor, Department of Physiology, UTHSCSA

1994-2001          Assistant Professor, Department of Medicine, UTHSCSA

1992-1994          Clinical Assistant Professor, Department of Medicine, UTHSCSA

1992-1994          AFAR/Merck Fellow, Geriatric Clinical Pharmacology, UTHSCSA

1990-2014          Staff Physician, Geriatric Evaluation and Management Clinic, STVHCS

1990-1992          Instructor, Department of Medicine, UTHSCSA

1990-1992          Fellowship in Geriatric Medicine, UTHSCSA

1988-1990          Residency in Internal Medicine, UTHSCSA

1985-1986          Internship in Family Practice/Internal Medicine, UTHSCSA

Other Experience and Professional Memberships

1994-present     American Board of Internal Medicine Certification of Added Qualifications-Geriatric Medicine

1990-present     American Board of Internal Medicine Certification

1990-present     American Physiological Society, Member

Honors

2024      Chair, NIH DSMB for Stopping Hydroxychloroquine in Elderly Lupus Disease (SHIELD)

2023      Chair, NIA DSMB for NAD Augmentation to Treat Diabetic Kidney Disease

2020      Invited Lecturer, Senotherapeutics: senolytics and senomorphics, NIH Workshop, Bethesda MD

2019      Invited Lecturer, Gerocentric Approach to HFpEF in Older Adults, NIH Workshop, Bethesda MD

2019      Invited Lecturer, Repurposing Drugs or Dietary Supplements, NIA Workshop, Bethesda MD

2017      Outstanding Service Award, STVHCS Former Prisoner of War Clinic

2015      Elected to VA National Former Prisoner of War Faculty

2010      Adjunct Professor, Department of Pharmacy, University of Texas at Austin

2006      Distinguished Teaching Professor, University of Texas System

2005       Invited Lecturer, AAPS Workshop: Microdialysis, Nashville TN

1998      Invited Lecturer, Shinshu University, Matsumoto, Japan

1998      Invited Lecturer, 1998 International Symposium on Human Biometeorology, Fujiyoshida, Japan

1997      Presidential Award for Excellence in Teaching, UTHSCSA

1994      Elected Fellow, Cardiovascular Section, American Physiological Society

1992      Geriatric Clinical Pharmacology Award, American Federation for Aging, New York, NY

1992      Alternate Payload Specialist Selectee, NASA, Space Shuttle Mission IML-2

1991      Invited Lecturer, NASA-Ames Research Center, Moffitt Field, CA

1990       Geriatric Clinical Pharmacology Award, Veterans Administration, Washington, DC

1985      Deafness Research Foundation Otological Research Fellowship for Medical Students

1985      Elected to Alpha Omega Alpha Medical Honor Society

Publications

Kellogg Publications over last decade

Trbovich M, Wu Y, Romo T, Koek W, Kellogg D. Mechanistic involvement of noradrenergic neuronal neurotransmitter release in cutaneous vasoconstriction during autonomic dysreflexia in persons with spinal cord injury. Auton Neurosci. 2024 Apr;252:103154. doi: 10.1016/j.autneu.2024.103154. Epub 2024 Jan 27. PubMed PMID: 38330594.

Trbovich M, Wu Y, Koek W, Wecht J, Kellogg D. Elucidating mechanisms of attenuated skin vasodilation during passive heat stress in persons with spinal cord injury. J Spinal Cord Med. 2023 May 9;:1-10. doi: 10.1080/10790268.2023.2203535. [Epub ahead of print] PubMed PMID: 37158753.

Trbovich M, Wu B, Koek W, Wecht J, Kellogg D. Are Thermoregulatory Sweating and Active Vasodilation in Skin Controlled by Separate Nerves During Passive Heat Stress in Persons With Spinal Cord Injury?. Top Spinal Cord Inj Rehabil. 2022 Fall;28(4):84-95. doi: 10.46292/sci21-00063. Epub 2022 Aug 10. PubMed PMID: 36457358; PubMed Central PMCID: PMC9678215.

Gonzales MM, Garbarino VR, Pollet E, Palavicini JP, Kellogg DL Jr, Kraig E, Orr ME. Biological aging processes underlying cognitive decline and neurodegenerative disease. J Clin Invest. 2022 May 16;132(10). doi: 10.1172/JCI158453. Review. PubMed PMID: 35575089; PubMed Central PMCID: PMC9106343.

Trbovich M, Wu Y, Koek W, Zhao J, Kellogg D Jr. Impact of tetraplegia vs. paraplegia on venoarteriolar, myogenic and maximal cutaneous vasodilation responses of the microvasculature: Implications for cardiovascular disease. J Spinal Cord Med. 2022 Jan;45(1):49-57. doi: 10.1080/10790268.2020.1761173. Epub 2020 Jun 4. PubMed PMID: 32496962; PubMed Central PMCID: PMC8890560.

Trbovich M, Ford A, Wu Y, Koek W, Wecht J, Kellogg D Jr. Correlation of neurological level and sweating level of injury in persons with spinal cord injury. J Spinal Cord Med. 2021 Nov;44(6):902-909. doi: 10.1080/10790268.2020.1751489. Epub 2020 Apr 21. PubMed PMID: 32315262; PubMed Central PMCID: PMC8725691.

Pandey A, Shah SJ, Butler J, Kellogg DL Jr, Lewis GD, Forman DE, Mentz RJ, Borlaug BA, Simon MA, Chirinos JA, Fielding RA, Volpi E, Molina AJA, Haykowsky MJ, Sam F, Goodpaster BH, Bertoni AG, Justice JN, White JP, Ding J, Hummel SL, LeBrasseur NK, Taffet GE, Pipinos II, Kitzman D. Exercise Intolerance in Older Adults With Heart Failure With Preserved Ejection Fraction: JACC State-of-the-Art Review. J Am Coll Cardiol. 2021 Sep 14;78(11):1166-1187. doi: 10.1016/j.jacc.2021.07.014. Review. PubMed PMID: 34503685; PubMed Central PMCID: PMC8525886.

Kellogg DL, Kellogg DL Jr, Musi N, Nambiar AM. Cellular Senescence in Idiopathic Pulmonary Fibrosis. Curr Mol Biol Rep. 2021;7(3):31-40. doi: 10.1007/s40610-021-00145-4. Epub 2021 Aug 12. Review. PubMed PMID: 34401216; PubMed Central PMCID: PMC8358258.

Trbovich M, Romo T, Polk M, Koek W, Kelly C, Stowe S, Kraus S, Kellogg D. The treatment of neurogenic lower urinary tract dysfunction in persons with spinal cord injury: An open label, pilot study of anticholinergic agent vs. mirabegron to evaluate cognitive impact and efficacy. Spinal Cord Ser Cases. 2021 Jun 10;7(1):50. doi: 10.1038/s41394-021-00413-6. PubMed PMID: 34112758; PubMed Central PMCID: PMC8192499.

Jiwani R, Wang CP, Orsak B, MacCarthy D, Kellogg D, Powers B, Wang J, Padala P, Padala K, Espinoza S. A geriatrics walking clinic improves hemoglobin A1c and timed gait in older veterans with type 2 diabetes. Geriatr Nurs. 2021 Mar-Apr;42(2):566-569. doi: 10.1016/j.gerinurse.2020.10.001. Epub 2020 Nov 4. PubMed PMID: 33158625.

Kellogg DL Jr, Darling H, Crawford B, Garcia AJ, Camacho V. An Interdisciplinary Clinic for Former Prisoners of War. Fed Pract. 2020 Apr;37(4):182-185. PubMed PMID: 32322150; PubMed Central PMCID: PMC7173639.

Espinoza SE, Orsak B, Wang CP, MacCarthy D, Kellogg D, Powers B, Conde A, Moris M, Padala PR, Padala KP. An Individualized Low-Intensity Walking Clinic Leads to Improvement in Frailty Characteristics in Older Veterans. J Frailty Aging. 2019;8(4):205-209. doi: 10.14283/jfa.2019.16. PubMed PMID: 31637407.

Kraig E, Linehan LA, Liang H, Romo TQ, Liu Q, Wu Y, Benavides AD, Curiel TJ, Javors MA, Musi N, Chiodo L, Koek W, Gelfond JAL, Kellogg DL Jr. A randomized control trial to establish the feasibility and safety of rapamycin treatment in an older human cohort: Immunological, physical performance, and cognitive effects. Exp Gerontol. 2018 May;105:53-69. doi: 10.1016/j.exger.2017.12.026. Epub 2018 Feb 3. PubMed PMID: 29408453; PubMed Central PMCID: PMC5869166.

Johnson JM, Kellogg DL Jr. Skin vasoconstriction as a heat conservation thermoeffector. Handb Clin Neurol. 2018;156:175-192. doi: 10.1016/B978-0-444-63912-7.00011-4. Review. PubMed PMID: 30454589.

Hodges GJ, Kellogg DL, Johnson JM. Effect of skin temperature on cutaneous vasodilator response to the β-adrenergic agonist isoproterenol. J Appl Physiol (1985). 2015 Apr 1;118(7):898-903. doi: 10.1152/japplphysiol.01071.2014. Epub 2015 Feb 19. PubMed PMID: 25701007; PubMed Central PMCID: PMC4385879.

Johnson JM, Minson CT, Kellogg DL Jr. Cutaneous vasodilator and vasoconstrictor mechanisms in temperature regulation. Compr Physiol. 2014 Jan;4(1):33-89. doi: 10.1002/cphy.c130015. Review. PubMed PMID: 24692134.