Peter J. Hornsby, Ph.D.
Professor
Personal Statement:
My research interests are in regenerative medicine, as described below. I also serve as the Co-Director of the San Antonio Nathan Shock Center and as Co-Leader of the Research Career Development Core of the San Antonio Older Americans Independence Center (Pepper Center). My teaching activities focus on gastrointestinal physiology, both within the Medical School and the Graduate School.
Education
B.A. (Honors), University of Oxford, 1971
Ph.D., University of London Institute of Cancer Research, 1974
Postdoctoral Fellowship: University of California San Diego
Research
Regenerative Medicine – Stem Cell Delivery. Our research focuses on modes of stem cell delivery to exert a therapeutic effect in age-related diseases. Most recently the lab’s research has concerned intranasal delivery of mesenchymal stem cells to the brain. 
“Human mesenchymal stem cells crossing the cribriform plate into the brain in a mouse. Human stem cells were labeled with quantum dots (red) and administered intranasally. Two hours later they are seen crossing the cribriform plate in this image (arrows). In (b) nuclei have been stained green. (c) is an overlay of (a) and (b). cp = cribriform plate; fo = fila olfactoria; lp = lamina propria; oe = olfactory epithelium; onl = olfactory nerve layer”
Affiliations
American Aging Association
Publications
| Publication Name | Year | Description | Type |
|---|---|---|---|
| Salmon, A. B., Nelson, J. F., Gelfond, J., Javors, M., Ginsburg, B., Lopez-Cruzan, M., Galvan, V., Fernandez, E., Musi, N., Ikeno, Y., Hubbard, G., Lechleiter, J., Hornsby, P. J., & Strong, R. | 2021 | San Antonio Nathan Shock Center: your one-stop shop for aging research. | GeroScience, 43(5), 2105–2118. |
| Hornsby, P. J. | 2021 | Induced pluripotent stem cells from nonhuman primates. | Advances in Stem Cell Biology vol 2, Birbrair, A., Academic Press, London, pp.45-57 |
| Hornsby, P. J. | 2021 | The nature of aging and the geroscience hypothesis. | Handbook of the Biology of Aging, 9th Ed., Musi, N.; Hornsby, P.J., Elsevier, London, pp.69-76 |
| Guderyon, M. J., Chen, C., Bhattacharjee, A., Ge, G., Fernandez, R. A., Gelfond, J., Gorena, K. M., Cheng, C. J., Li, Y., Nelson, J. F., Strong, R. J., Hornsby, P. J., Clark, R. A., & Li, S. | 2020 | Mobilization-based transplantation of young-donor hematopoietic stem cells extends lifespan in mice. | Aging cell, 19(3), e13110. |
| Moreira, A., Winter, C., Joy, J., Winter, L., Jones, M., Noronha, M., Porter, M., Quim, K., Corral, A., Alayli, Y., Seno, T., Mustafa, S., Hornsby, P., & Ahuja, S. | 2020 | Intranasal delivery of human umbilical cord Wharton's jelly mesenchymal stromal cells restores lung alveolarization and vascularization in experimental bronchopulmonary dysplasia. | Stem cells translational medicine, 9(2), 221–234. |
| Farnsworth, S. L., Qiu, Z., Mishra, A., & Hornsby, P. J. | 2019 | Optimization of Differentiation of Nonhuman Primate Pluripotent Cells Using a Combinatorial Approach. | Methods in molecular biology (Clifton, N.J.), 1919, 187–197. |
| Balgi-Agarwal, S., Winter, C., Corral, A., Mustafa, S. B., Hornsby, P., & Moreira, A. | 2018 | Comparison of Preterm and Term Wharton's Jelly-Derived Mesenchymal Stem Cell Properties in Different Oxygen Tensions. | Cells, tissues, organs, 205(3), 137–150. |
| Galeano C, Qiu Z, Mishra A, Farnsworth SL, Hemmi JJ, Moreira A, Edenhoffer P, Hornsby, PJ. | 2018 | The route by which intranasally delivered stem cells enter the central nervous system. | Cell Transpl. (in press) |
| Archambault J, Moreira A, McDaniel D, Winter L, Sun L, Hornsby PJ. | 2017 | Therapeutic potential of mesenchymal stromal cells for hypoxic ischemic encephalopathy: A systematic review and meta-analysis of preclinical studies. | PLoS One. 12:e0189895. |
| Moreira A, Alayli Y, Balgi S, Winter C, Kahlenberg S, Mustafa S, Hornsby PJ. | 2017 | Upcycling umbilical cords: bridging regenerative medicine with neonatology. | J Matern Fetal Neonatal Med. 2017 Nov 27:1-10. doi: 10.1080/14767058.2017.1405387. |
| Moreira A, Kahlenberg S, Hornsby PJ. | 2017 | Therapeutic potential of mesenchymal stem cells for diabetes. | J Mol Endocrinol. 59:R109-R120. |
| Hemmi JJ, Mishra A, Hornsby, PJ. | 2017 | Overcoming barriers to reprogramming and differentiation in nonhuman primate induced pluripotent stem cells. | Primate Biol. 4:153-162. |
| Mishra A, Qiu Z, Farnsworth SL, Hemmi JJ, Li M, Pickering AV, Hornsby PJ. | 2016 | Induced Pluripotent Stem Cells from Nonhuman Primates. | Methods Mol Biol. 1357:183-93. |
| Qiu Z, Mishra A, Li M, Farnsworth SL, Guerra B, Lanford RE, Hornsby PJ. | 2015 | Marmoset induced pluripotent stem cells: Robust neural differentiation following pretreatment with dimethyl sulfoxide. | Stem Cell Res. 15:141-50 |