Biomolecular NMR Core

We offer state-of-the-art high field NMR instrumentation for structural studies of biological macromolecules. The instrumentation presently available includes four-channel Bruker Avance 500, 600, and 700 MHz NMR spectrometers equipped with cryoprobes.

X-ray Crystallography Core Laboratory

We provide state-of-the-art resources to researchers at UT Health San Antonio and external users that enable the detailed 3-D analyses of biological macromolecules that play important roles in human health. We also offer advice and technical assistance in sample preparation. Visit our webpage to see a list of recent publications from collaborative research projects involving X-ray crystallography.

Center for Macromolecular Interactions (CMMI)

We offer access to sophisticated instrumentation and expertise for the study of macromolecular interactions utilizing a number of state-of-the-art biophysical approaches including surface plasmon resonance (SPR), calorimetry (ITC and DSC), light scattering (DLS and SLS), and analytical ultracentrifugation (AUC). The facility provides experimental design, data analysis, training,  grant preparation services, and protein expression and purification services (PEPcore). Our instrumentation and services can be used for the characterization of protein-protein, protein-lipid, protein-nucleic acid and protein-small molecule interactions.

Mass Spectrometry Core Laboratory

Recent advances in mass spectrometry instrumentation and data analysis have revolutionized the way proteins are identified and quantified in biomedical research. Mass Spectrometry Laboratory offers a wide spectrum of proteomics analysis including 1-D and 2-D electrophoresis, in-gel digestion, robotic gel spot excision, protein identification, sequence characterization of peptides, identification of post-translational modification sites

High Throughput/Content Screening Facility

The HTS Facility is a state-of-the-art technological hub that performs HTS of chemical and natural product libraries, including new fragment-based libraries (associated with the NMR Core Facility) and, ultimately, miRNA libraries.