Differential Scanning Calorimetry (DSC) DSC is a powerful technique to characterize temperature-induced conformational changes in proteins or other macromolecules. It is useful for measuring the melting temperature of a protein, which could be used to determine whether mutagenesis of a protein results in changes in its thermal stability (i.e. fold).  We provide access to a Microcal VP-DSC instrument, and the expertise to design, perform and analyze experiments.