Home » Events » Grand Rounds – AAFP POEMs: SGLT-2 Inhibitors and GLP-1 Receptor Agonists Reduce All-Cause Mortality Amongst Other Patient Benefits

Grand Rounds – AAFP POEMs: SGLT-2 Inhibitors and GLP-1 Receptor Agonists Reduce All-Cause Mortality Amongst Other Patient Benefits

Event Details:

Overview:

Brief review of pharmacotherapy of GLP-1 RA and SGLT2-I reminds providers that GLP-1 RA work by activating insulin synthesis and release, delaying gastric emptying, and increasing satiety. SGLT-2 inhibitors work by reducing renal tubular glucose reabsorption, increasing urinary glucose excretion, ultimately reducing serum glucose with additional weight loss and antihypertensive benefits independent of beta cell function. Review of two separate meta-analyses conclude that SGLT2-I therapy and GLP-1 RA therapy result in reduction in all-cause mortality, CV mortality, myocardial infarction, and adverse renal outcomes. Call to action for physicians and providers to routinely evaluate need for use of SGLT2-I in every patient with cardiometabolic or renal disease, not just diabetic patients, and to work closely with pharmacy teams to assist patients with medication cost barriers.

Objectives:

• Summarize the pharmacology of available GLP-1 receptor agonists and SGLT-2 inhibitors.
• Analyze two meta-analyses evaluating the effect of SGLT-2 inhibitors and GLP-1 receptor agonists on patient outcomes and patient mortality.
• Promote increased use of SGLT-2 inhibitors and GLP-1 receptor agonists in the primary care setting.

Financial Disclosures:

Etny Candelario, MD, Rachel Walker, MD and their faculty mentor Miguel Palacios, MD have no financial relationships with ineligible companies to disclose.

The Family & Community Medicine Professional Development and Grand Rounds Committee members (Mark Nadeau, MD, Marcy Wiemers, MD, Maria Del Pilar Montañez Villacampa, MD, Christine Song, DO, Nehman Andry, MD, Gabriela Gibson-Lopez, PsyD, Margaret Finley, MD, Yun Shi, MD, Stacy Ogbeide, PsyD, Lauren Fuller, MD, and Nichole Rubio) have no financial relationships with ineligible companies to disclose.

The Family & Community Medicine Professional Development and Grand Rounds Committee member Carlos Roberto Jaén, MD has disclosed he receives royalties from General Practice and Family Medicine for being UpToDate Editor-in-Chief.

AMA PRA Category 1 Credits™ (1.00 hours), Non-Physician Participation Credit (1.00 hours)

Target Audience:

Specialties – Primary Care; Family Medicine  
Faculty, residents, other health care providers and staff from our department; physicians and health care providers from San Antonio and South Texas; and medical students in our third-year clerkship and fourth year rotations. 

Accreditation:

The UT Health Science Center San Antonio is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

Credit Designation:

The UT Health Science Center San Antonio designates this live activity up to a maximum of 1.00 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Nurses and other healthcare professionals will receive a Certificate of Attendance. For information on applicability and acceptance, please consult your professional licensing board.

For activity related questions, please contact:

Name: Nichole Rubio- FCM Grand Rounds Coordinator
Email: rubion@uthscsa.edu

For CME general questions, please contact:

Ph: (210) 567-4445
Email: cme@uthscsa.edu