Pharmacologic Therapies in Patients with Exacerbation of Chronic Obstructive Pulmonary Disease: A Systematic Review with Meta-Analysis

Overview:

Chronic Obstructive Pulmonary Disease (COPD) is the fourth leading cause of death in the United States and Primary Care providers play a key role in the diagnosis and treatment of this disease.  In this presentation, Dr. Hamilton-Bevil will discuss the systematic review with meta-analysis of pharmacologic therapies used for 10,758 patients from 68 randomized controlled trials with COPD exacerbation. There is strong evidence for use of antibiotics and systemic corticosteroids in improving dyspnea and reducing treatment failure for adults with COPD exacerbations, ranging from mild to severe. Other treatments that are part of our usual care, including use of short-acting bronchodilators, did not have clear evidence for resolving exacerbations nor lowering rates of treatment failure.

Objectives:

1.  Summarize  various pharmacologic therapies used in treating COPD exacerbations and explain their comparative effectiveness.
2.   Identify evidence that supports use of antibiotics and systemic corticosteroids for COPD exacerbations, independent of setting or severity.
3.  Discriminate among therapies have insufficient evidence for successful treatment as well as adverse effects.

Presenter:

Hayley Hamilton-Bevil, MD
PGY3
Department of Family and Community Medicine
UT Health San Antonio

 

Financial Disclosures:

Beverly Hamilton-Bevil, MD and her faculty mentor Tharani Ravi, MD have no financial relationships with ineligible companies to disclose.

The Family & Community Medicine Professional Development and Grand Rounds Committee members (Mark Nadeau, MD, Marcy Wiemers, MD, Maria Del Pilar Montañez Villacampa, MD, Christine Song, DO, Nehman Andry, MD, Gabriela Lopez, PsyD, Yun Shi, MD, Stacy Ogbeide, PsyD, Inez I. Cruz, PhD, and Nichole Rubio) have no financial relationships with ineligible companies to disclose.

The Family & Community Medicine Professional Development and Grand Rounds Committee member Carlos Roberto Jaén, MD has disclosed he receives royalties from General Practice and Family Medicine for being UpToDate Editor-in-Chief.

Credits:

AMA PRA Category 1 Credits™ (1.00 hours), Non-Physician Participation Credit (1.00 hours)

Target Audience:

Specialties – Primary Care; Family Medicine
Faculty, residents, other health care providers and staff from our department; physicians and health care providers from San Antonio and South Texas; and medical students in our third-year clerkship and fourth year rotations.

Accreditation:

The UT Health Science Center San Antonio is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

Credit Designation:

The UT Health Science Center San Antonio designates this live activity up to a maximum of 1.00 AMA PRA Category 1 Credits™.

Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Nurses and other healthcare professionals will receive a Certificate of Attendance. For information on applicability and acceptance, please consult your professional licensing board.

For activity related questions, please contact:
Name: Nichole Rubio- FCM Grand Rounds Coordinator
Email: rubion@uthscsa.edu

For CME general questions, please contact
Ph: (210) 567-4445
Email: cme@uthscsa.edu