Contact

Department

Program Lead - Host Pathogen Interactions, Texas Biomedical Research Institute

Ling, Binhua (Julie), M.D., M.MED.SC., Ph.D.

Adjunct Professor

Personal Statement:

Dr. Binhua “Julie” Ling is a Professor and Co-Lead of the Host Pathogen Interaction Program-Disease Intervention & Prevention, Faculty of Host Pathogen Interaction, and Program Leadership of the Southwest National Primate Research Center

Dr. Ling’s laboratory is interested in using simian immunodeficiency virus (SIV) or chimeric simian-human immunodeficiency viruses (SHIVs) in rhesus macaques, particularly the Chinese-origin rhesus macaques (cRM), as a nonhuman primate model to study the persistence of HIV in tissues specifically the gut and central nervous system (CNS) to develop novel drug delivery and therapeutic strategies to eradicate HIV. Her team also aims to understand what controls or spreads the virus in a host with or without therapeutic intervention. Additional focuses are HIV comorbidities such as HIV/SIV and aging.

Dr. Ling’s current research is supported by NIH. She has a broad background in molecular virology, immunology, and many years of work experience and expertise in nonhuman primate models in key areas of HIV/SIV pathogenesis and cure studies.

Education

Postdoc, Tulane University, New Orleans, LA
Postdoc, Aaron Diamond AIDS Research Center, New York, NY
Ph.D., Peking University Health Science Center, Peking University, Beijing, China
M. Biomed. Sci., Peking University Health Science Center, Beijing, China
M.D. equivalent, Jiangxi Medical College, Jiangxi, China

Awards & Accomplishments

2022-Outreach Champion 2022 Award, Texas Biomedical Research Institute

2022-Scientific Advisory Committee member, the 39th Annual Symposium on Nonhuman Primate Models for AIDS.

2021-2025-Standing member, HIV Immunopathogenesis and Vaccine Development (HIVD), NIH Center for Scientific Review.

2021-Scientific Advisory Committee member, the 38th Annual Symposium on Nonhuman Primate Models for AIDS.

2018-Outstanding achievement and commitment to excellence in total competitive research funding. Tulane University School of Medicine.

2016-Scientific Advisory Committee member, the 34th Annual Symposium on Nonhuman Primate Models for AIDS.

Publications

  1. Premadasa LS, Lee E, McDew-White M, Alvarez X, Jayakumar S, Ling B, Okeoma CM,Byrareddy SN, Kulkarni S, and Mohan M. Cannabinoid enhancement of long non-coding RNA MMP25-AS1-MMP25 (MT6-MMP) interactions is associated with reduced neutrophil transendothelial migration and intestinal epithelial barrier dysfunction in chronic HIV/SIV infection. JCI Insight, 2023 (in press).
  2. Solis-Leal A, May AM, Mohan M, Dufour JP, and Ling B*. Duration of antiretroviral therapy impacts the degree of residual SIV infection in the gut in long-term non-progressing Chinese rhesus macaques. J Med Virol, 2023 Jan;95(1):e28185. doi:10.1002/jmv.28185. Epub 2022 Oct *: corresponding author. PMID: 36181356
  3. 3Wu F, Liu YZ, and Ling B*. MTD: a unique pipeline for host and meta-transcriptome joint and integrative analyses of RNA-seq data. Brief Bioinform, 2022 Apr 4;bbac111. doi: 10.1093/bib/bbac111. PMID: 35380623.
  4. Shah S, Wong L, Ellis K, Bodnar B, Saribas S, Ting J, Wei Z, Tang Y, Wang X, Wang H, Ling B, Margolis DM, Garcia JV, Hu W, and Jiang G. Microglia-specific promoter activities of human HexB gene. Front Cell Neurosci, 2022, Mar 10;16:808598. doi: 10.3389/fncel.2022.808598. eCollection 2022. PMID: 35360489
  5. Solis-Leal A, Siddiqui S, Wu F, Mohan M, Hu W, Doyle-Meyers L, Dufour JP, and Ling B*. Neuroinflammatory profiling in SIV-infected Chinese-origin rhesus macaques on antiretroviral therapy. Viruses, 2022 Jan 13;14(1):139. doi: 10.3390/v14010139. PMID: 35062343
  6. McDew-White M, Lee E, Alvarez X, Sestak K, Ling B, Byrareddy SN, Okeoma CM, and Mohan M. Cannabinoid control of gingival immune activation in chronic HIV/SIV infection involve modulation of the Indoleamine-2,3-Dioxygenase pathway and salivary microbiome. EBioMedicine, 2022 Jan;75:103769. doi: 10.1016/j.ebiom.2021.103769. PMID: 34954656
  7. Chu Y, Qin C, Feng W, Sheriston C, Khor YJ, Medrano-Padial C, Watson BE, Chan T, Ling B, Stocks MJ, Fischer PM, and Gershkovich P. Oral administration of tipranavir with long-chain triglyceride results in moderate intestinal lymph targeting but no efficient delivery to HIV-reservoir in mesenteric lymph nodes. International Journal of Pharmaceutics, 2021, 602:120621.
  8. Mancuso P, Chen C, Kaminski R, Gordon J, Liao S, Robinson JA, Liu H, Sarlyer IK, Sariyer R, Peterson TA, Donadoni M, Williams JB, Siddiqui S, Bunnell B, Ling B*, MacLean AG*, Burdo T*, and Khalili K*. CRISPR based editing of SIV proviral DNA in ART treated non-human primates. Nature Communications, 2020, 11, Article number:6065. *Corresponding author.
  9. Siddiqui S, Bao D, Doyle-Meyers L, Dufour J, Wu Y, Liu Y, and Ling B*. Reversible changes ofthe gut microbiota in rhesus macaques on short- or long-term antiretroviral therapy after SIV infection. Scientific Reports, 2020, 10, Article number: 19056. *Corresponding author. Siddiqui S, Perez S, Gao Y, Doyle-Meyers L, Foley BT, Li Q and Ling B*. Persistent viral reservoirs in lymphoid tissues in SIV-infected Chinese-origin rhesus macaques on suppressive antiretroviral therapy. Viruses, 2019, Jan 27;11(2). pii: E105. doi: 10.3390/v11020105. *Corresponding author.
  10. Xu W, Luo Z, Alekseyenko AV, Martin L, Wan Z, Ling B, Qin Z, Heath S, Maas K, Cong X, Wei Jiang W. Distinct systemic microbiome and microbial translocation are associated with plasma level of anti-CD4 autoantibody in HIV infection. Scientific Report, 2018, 8:12863.
  11. Jiang W, Luo Z, Martin L, Wan Z, Fu P, Wagner A, Ling B, Heath S, Azizul H and McRae-Clark A. Drug use is associated with anti-CD4 IgG-mediated CD4+ T cell death and poor CD4+ T cell recovery in viral-suppressive HIV-infected individuals under antiretroviral therapy. Current HIV Research, 2018, 16: 143-150.
  12. Perez S, Johnson AM, Xiang S, Li J, Foley BT, Doyle-Meyers, Panganiban A, Kaur A, Veazey RS, Wu Y, and Ling B*. Persistence of SIV in the brain of SIV-infected Chinese rhesus macaques with or without antiretroviral therapy. Journal of Neurovirology, 2018, 24: 62-74. *Corresponding author.
  13. Veazey, R and Ling B*. Comparative susceptibility of rhesus macaques of Indian and Chinese origin to vaginal SHIV transmission as models for HIV prevention research. AIDS Res Hum Retroviruses, 2017, Dec, 33(12):1199-1201. *Corresponding author.
  14. Yi F, Guo J, Spear M, He S, Kehn-Hall K, Fontenot J, Yin Y, Bibian M, Park CM, Zheng K, ParkH, Soloveva V, Gharaibeh D, Retterer C, Zamani R, Pitt ML, Naughton J, Jiang Y, Shang H, Hakami RH, Ling B, Young JT, Bavari S, Feng Y and Wu Y. Discovery of novel small moleculeinhibitors of LIM domain kinase for inhibiting HIV-1 and other viruses. Journal of Virology, 2017,Jun 9;91(13).
  15. Krebs K, Tian M, Asmal M, Ling B, Nelson L, Henry K, Gibson R, Li Y, Han W, Shattock R, Veazey R, Letvin N, Arts E, and Gao Y. Infection of rhesus macaques with a pool of simian immunodeficiency virus with the envelope genes from acute HIV-1 infections. AIDS Research and Therapy, 2016, 13:41-61.