Segovia, Jesus, Ph.D.
Adjunct Assistant Professor
Personal Statement:
Jesus A. Segovia, Ph.D., received his bachelor’s degree in Biology from Baylor University in 2004. He then attended graduate school at Texas A&M International University and earned a master’s degree in Biology, with a focus in Microbiology, in 2008. In 2009, he joined the Department of Microbiology and Immunology at the University of Texas Health Science Center at San Antonio. In early 2010, Segovia joined the laboratory of Santanu Bose to pursue his Ph.D. in the field of innate immunity and inflammation.
Publications
Shil N, Mainali Pokharel S, Segovia JA, Tsai S-Y, Chang T-H and Bose S. 25-hydroxycholesterol activates integrin-FAK signaling and links TLR, Nod2, TNFR pathways with signaling to intensify inflammatory response. Commun. (in press)
Segovia JA, Chang TH, Winter VT, Coalson JJ, Cagle MP, Pandranki, L Bose S, Baseman JB and Kannan TR. NLRP3 is a critical regulator of inflammation and innate immune cell response during Mycoplasma pneumoniae Infect Immun (2017). PMCID: PMC5736809
Lizcano A, Akula Suresh Babu R, Shenoy AT, Saville AM, Kumar N, D’Mello A, Hinojosa CA, Gilley RP, Segovia JA, Mitchell TJ, Tettelin H and Orihuela CJ. Transcriptional organization of pneumococcal psrP-secY2A2 and impact of GtfA and GtfB deletion on PsrP-associated virulence properties. Microbes Infect (2017)
Tsai SY, Segovia JA, Chang TH, Shil NK, Pokharel SM, Kannan TR, Baseman JB, Pagé N, Cesaro A, Tessier PA and Bose S. Regulation of TLR3 activation by S100A9. J Immunol doi:10.4049/jimmunol.1500378 (2015). PMCID: PMC4747058
Segovia JA, Chang TH, Tsai SY, Hakala KW, Weintraub ST, Short JD and Bose S. Nedd8 regulates inflammasome-dependent caspase-1 activation. Mol Cell Biol 35(3):582—597 (2015). PMCID: PMC4285429
Bose S, Segovia JA, Somarajan SR, Chang TH, Kannan TR and Baseman JB. ADP-ribosylation of NLRP3 by Mycoplasma pneumoniae CARDS toxin regulates inflammasome activity. MBio 5(6):e02186-14 (2015). PMCID: PMC4278538
Thinwa J, Segovia JA, Bose S and Dube PH. Integrin-mediated pathogen recognition leads to inflammasome-dependent IL-18 secretion from intestinal epithelial cells. J Immunol 193(3):1373-82 (2014). PMCID: PMC4174679
Tsai SY, Segovia JA, Mgbemena V, Chang TH, Morris IR, Berton MT, Tessier PA, Tardif MR, Cesaro A and Bose S. DAMP molecule S100A9 acts as a molecule pattern to enhance inflammation during Influenza A Virus infection: Role of DDX21-TRIF-TLR4-MyD88 pathway. PLoS Pathog 10(1): e1003848 (2014) doi:10.1371/journal.ppat.1003848. PMCID: PMC3879357
Mgbemena V*, Segovia JA*, Chang TH and Bose S. KLF6 and iNOS regulates apoptosis during respiratory syncytial virus infection. Cell Immunol 283(1-2):1-7 (2013). PMCID: PMC3744625 *Co-first authors
Mgbemena V*, Segovia JA*, Chang TH, Tsai SY, Cole GT, Hung CY and Bose S. Transactivation of inducible nitric oxide synthase gene by Krüppel-like factor 6 regulates apoptosis during influenza A virus infection. J Immunol 189(2):606—615 (2012). PMCID: PMC3392426 *Co-first authors
Segovia JA, Sabbah A, Mgbemena V, Tsai SY, Chang TH, Berton M, Morris IR, Allen IC, Ting JP and Bose S. TLR2/MyD88/NF-κB pathway, reactive oxygen species, potassium efflux activates NLRP3/ASC inflammasome during respiratory syncytial virus infection. PLoS One 7:e29695 (2012). PMCID: PMC3266238
Chang TH, Segovia JA, Sabbah A, Mgbemena V and Bose S. Cholesterol-rich lipid rafts are required for release of infectious human respiratory syncytial virus particles. Virology 422: 205—211 (2012). PMCID: PMC3249476
Mgbemena V, Segovia JA, Chang TH and Bose S. Krüppel-like factor 6 regulates transforming growth factor-β gene expression during human respiratory syncytial virus infection. Virology J 8:409—415 (2011). PMCID: PMC3170303