Molecular Pathology of Cell Injury Research

The fundamental mechanisms of cell death remain elusive, however, it is clear that a complex collection of apoptotic and anti-apoptotic signals control this process in most cells. Using diverse models of ischemia (hypoxia-reoxygenation) and energy depletion, the role of caspases in apoptosis and necrosis are being evaluated. It is anticipated that these efforts will lead to a better understanding of the molecular mechanisms of necrotic and apoptotic cell death, with emphasis on injury paradigms that lead to lethal outcomes during hypoxia and reoxygenation.

Pathology Faculty

Pothana Saikumar, Ph.D

Manjeri A. Venkatachalam, M.B., B.S.

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