Chromosome Mosaicism Analysis (RCA-MOS)
CPT Code(s)
a. Peripheral Blood – 88230, 88263, 88280, 88291 b. Skin – 88233, 88263, 88280, 88291
Synonym(s)
Mosaicism Study
Performed
In-House
Methodology
PHA stimulated short-term culture / In Situ long-term culture initiated using Collagenase for enzyme digestion; chromosome preparation and banding; microscopic analysis of up to 50 cells and karyotype; interpretation and report
Panel/Profile Components
N/A
Critical Values
N/A
Specimen Collection / Handling Requirements
- Peripheral blood collected in green top – sodium heparin tube (Peripheral Blood)
- Collected in sterile specimen cup or sterile 15 mL tube with RPMI or sterile saline (Skin)
- Store and ship at room temperature
- Avoid freezing or heating
- Ship within 24 hours
- Delay > 24 hours – Refrigerate the sample
- A complete requisition slip must accompany all specimens and the specimen must be labeled with the patient’s name and identification
- ANY SPECIMENS RECEIVED WITHOUT A COMPLETE REQUISTION OR AN UNLABELED SPECIMEN WILL BE REJECTED.
- All requisition must have a valid ICD-10 code/clinical indication and must have the name of an authorized Any sample without this information will be rejected.
Minimum Specimen Requirements
Optimal Quantity: 4-5 ml; Minimum Quantity: 1-2 ml (Peripheral Blood); Optimal Quantity: 2 cm3; Minimum Quantity: 1 cm3 (Skin)
Turnaround time
Total testing time: 10 days (Peripheral Blood), 6 weeks (Skin)
Communication
- Turnaround time non-conformity: Email or call Pathologist on request form to notify them of the
- Technical Updates: Email Applicable Laboratory
Quality
QA/Utilization Report