Erik Dean Marchant

Research

Erik is currently investigating skeletal muscle metabolism and function in the context of aging and overnutrition. Specifically, he has investigated ultrasound as a possible therapeutic for insulin resistance and diabetes in aged mice. He is also investigating the role of mTORC1 hyperactivation in skeletal muscle and its role in the development of insulin resistance.

Awards & Accomplishments

2024 – Poster Presentation Travel Award, FASEB Conference on Nutrient Sensing and Signaling in Metabolism

2023 – T32 Training Grant Recipient, Biology of Aging, UT Health San Antonio

2022 – Presidential Scholarship, University of Texas Medical Branch at Galveston

2022 – Research Recognition Award, American Physiological Society, Endocrinology and Metabolism

Publications

• Kaluhiokalani JP, Wallace TE, Ahmadi M, Marchant ED, Mehling J, Altuhov S, Dorff A, Leach OK, James JJ, Hancock CR, Hyldahl RD, Gifford JR. Six weeks of localized passive heat therapy elicits some exercise-like improvements in resistance artery function. J Physiol. 2024 Jul 14.
• Xu G, Quan S, Schell J, Gao Y, Varmazyad M, Sreenivas P, Cruz D, Jiang H, Pan M, Han X, Palavicini JP, Zhao P, Sun X, Marchant ED, Rasmussen BB, Li G, Katsumura S, Morita M, Munkácsy E, Horikoshi N, Chocron ES, Gius D. Mitochondrial ACSS1-K635 acetylation knock-in mice exhibit altered metabolism, cell senescence, and nonalcoholic fatty liver disease. Sci Adv. 2024 May 17;10(20):eadj5942.
• Marchant ED, Nelson WB, Hyldahl RD, Gifford JR, and Hancock CR. Passive heat stress induces mitochondrial adaptations in skeletal muscle. Int J Hyperthermia: 40(1):2205066, 2023.
• Marchant ED, Kaluhiokalani JP, Wallace TE, Ahmadi M, Dorff A, Linde JJ, Leach OK, Hyldahl RD, Gifford JR, and Hancock CR. Localized Heat Therapy Improves Mitochondrial Respiratory Capacity but Not Fatty Acid Oxidation. Int J Mol Sci: 23(15):8500, 2022.
• Hansen JM, Lucas SM, Ramos CD, Green EJ, Nuttall DJ, Clark DS, Marchant ED, Hancock CR, and Piorczynski TB. Valproic acid promotes SOD2 acetylation: a potential mechanism of valproic acid-induced oxidative stress in developing systems. Free Radic Res: 1-15, 2022.
• *Mackay AD, *Marchant ED, Louw M, Thomson DM, and Hancock CR. Exercise, but Not Metformin Prevents Loss of Muscle Function Due to Doxorubicin in Mice Using an In Situ Method. Int J Mol Sci 22, 2021. (*Authors contributed equally to this work)
• Marchant ED, Marchant ND, Hyldahl RD, Gifford JR, Smith MW, and Hancock CR. Skeletal Muscle Mitochondrial Function following a 100-km Ultramarathon: A Case Study in Monozygotic Twins. Med Sci Sports Exerc, 2021.
• Marchant ED, Corbin WM, Eyre CL, and Marchant ND. Unlike a high-fat diet model, mitochondrial ROS production does not appear to contribute to bed rest-induced insulin resistance. J Physiol 598: 2289-2290, 2020.
• Mackay AD, Marchant ED, Munk DJ, Watt RK, Hansen JM, Thomson DM, and Hancock CR. Multitissue analysis of exercise and metformin on doxorubicin-induced iron dysregulation. Am J Physiol Endocrinol Metab 316: E922-E930, 2019.
• Anderson JG, Hintze K, and Marchant ED. Restricting branched-chain amino acids: an approach to improve metabolic health. J Physiol 596: 2469-2470, 2018.