Mei Hu, Ph.D.

Publications

1. Zhu D, Zhang J, Gao F, Hu M, Hashem J and Chen C. (2023) Augmentation of 2-arachidonoylglycerol signaling in astrocytes maintains synaptic functionality by regulation of miRNA-30b. Experimental Neurology 361:114292. PMID: 36481187
2. Gao F, Hu M, Zhang J, Hashem J and Chen C. (2022) TDP-43 drives synaptic and cognitive deteriorations following traumatic brain injury. Acta Neuropathologica 144: 187-210. PMID: 35713704
3. Hu M, Zhu D, Zhang J, Gao F, Hashem J, Kingsley P, Marnett LJ, Mackie K and Chen C. (2022) Enhancing endocannabinoid signaling in astrocytes promotes recovery from traumatic brain injury.  Brain 145 (1): 179-193. PMID: 35136958
4. Hashem J, Hu M, Zhang J, Gao F, and Chen C. (2021) Inhibition of 2-arachidonoylglycerol metabolism alleviates neuropathology and improves cognitive function in a tau mouse model of Alzheimer’s disease.  Molecular Neurobiology 58: 4122-4133. PMID: 33939165
5. Liu C, Tan Y, Li D, Tang S, Wen X, Long Y, Sun H, Hong H, and Hu M. (2020) Zileuton ameliorates depressive-like behaviors, hippocampal neuroinflammation, apoptosis and synapse dysfunction in mice exposed to chronic mild stress. International Immunopharmacology 78:105947. PMID: 31796384

6. Song Y, Hu M, Zhang J, Teng Z and Chen C. (2019) A novel mechanism of synaptic and cognitive impairments mediated via microRNA-30b in Alzheimer’s disease. EBioMedicine 39:409-421 PMID: 30522932
7. Zhang J, Teng Z, Song Y, Hu M and Chen C. (2015) Inhibition of monoacylglycerol lipase prevents chronic traumatic encephalopathy-like neuropathology in a mouse model of repetitive mild closed head injury.  Journal of Cerebral Blood Flow & Metabolism 35: 443-453. PMID: 25492114
8. Zhang J, Hu M, Teng Z, Tang Y and Chen C. (2014) Synaptic and cognitive improvements by inhibition of 2-AG metabolism are through upregulation of microRNA-188-3p in a mouse model of Alzheimer’s disease.  Journal of Neuroscience 34:14919-14933. PMID: 25378159
9. Hu M, Sun Y, Zhou Q, Auberson PY, Chen L, Hu Y, Luo C, Wu J, Zhu D and Li L. (2009) Reduced spatial learning in mice treated with NVP-AAM077 through down-regulating neurogenesis. European Journal of Pharmacology 622：37-44. PMID: 19765576

10. Hu M, Sun Y, Zhou Q, Chen L, Hu Y, Luo C, Wu J, Xu J, Li L and Zhu D. (2008) Negative regulation of neurogenesis and spatial memory by NR2B-containing NMDA receptors. Journal of Neurochemistry 106: 1900-1913. PMID: 18624924

11. Luo C, Zhu X, Zhou Q, Wang B, Wang W, Cai H, Sun Y, Hu M,  Jiang J, Hua Y, Han X and Zhu D. (2007)  Reduced neuronal nitric oxide synthase is involved in ischemia-induced hippocampal neurogenesis by up-regulating inducible nitric oxide synthase expression. Journal of Neurochemistry 103: 1872-1882. PMID: 17854382

12. Zhou Q, Hu Y, Hua Y, Hu M, Luo C, Han X, Zhu X, Wang B, Xu J and Zhu D. (2007)   Neuronal nitric oxide synthase contributes to chronic stress-induced depression by suppressing hippocampal neurogenesis. Journal of Neurochemistry 103: 1843-1854. PMID: 17854383

13. Jiang J, Wang W, Sun Y, Hu M, Li F and Zhu D. (2007) Neuroprotective effect of curcumin on focal cerebral ischemic rats by preventing blood-brain barrier damage. European Journal of Pharmacology 561:54–62. PMID: 17303117