DepartmentCellular and Integrative Physiology
Mei Hu, Ph.D.
Chu Chen, Ph.D.
1988 - 1993 BS, Pharmacology, China Pharmaceutical University, China
1993 - 1996 MS, Biochemical Pharmacology, China Pharmaceutical University, China
2004-2007 PhD, Molecular Pharmacology, Nanjing Medical University, China
1.Synaptic and Cognitive Improvements by Inhibition of 2-AG Metabolism Are through Upregulation of MicroRNA-188-3p in a Mouse Model of Alzheimer’s Disease. JianZhang, MeiHu, ZhaoqianTeng, Ya-PingTang,and ChuChen. The Journal of Neuroscience, 2014 ,34(45): 14919–14933
2. Inhibition of monoacylglycerol lipase prevents chronic traumatic encephalopathy – like neuropathology in a mouse model of repetitive mild closed head injury. JianZhang , Zhaoqian Teng, YunpingSong, Mei Hu, Chu Chen, Journal of Cerebral Blood Flow&Metabolism ,(2015),35:443–453
3. A novel mechanism of synaptic and cognitive impairments mediated via microRNA-30b in Alzheimer’s disease. Yunping Song, Mei Hu, Jian Zhang, Zhao-qian Teng,Chu Chen. EBioMedicine, （2019）39: 409-421
4.Reduced spatial learning in mice treated with NVP-AAM077 through down-regulating neurogenesis. Mei Hu, Yong-Jun Sun,Qi-Gang Zhou, Yves P. Auberson, Ling Chen, Yao Hu, Chun-Xia Luo, Jia-Yi Wu, Dong-Ya Zhu and Li-Xin Li. Eur J Pharmacol, 2009 ；622：37-44
5. Negative regulation of neurogenesis and spatial memory by NR2B-containing NMDA receptors. M Hu, YJ Sun, QG Zhou, L Chen, Y Hu, CX Luo, JY Wu, JS Xu, LX Li, and DY Zhu. J Neurochem, 2008; 106(4): 1900-13
6.Neuronal nitric oxide synthase contributes to chronic stress-induced depression by suppressing hippocampal neurogenesis. QG Zhou, Y Hu, Y Hua, M Hu, CX Luo, X Han, XJ Zhu, B Wang, JS Xu, and DY Zhu.J Neurochem, 2007; 103(5): 1843-54.
7.Protective effects of tauroursodeoxycholic acid on lipopolysaccharide-induced cognitive impairment and neurotoxicity in mice.Wu X, Liu C, Chen L, Du YF, Hu M, Reed MN, Long Y, Suppiramaniam V, Hong H, Tang SS. Int Immunopharmacol, 2019 Apr 12;72:166-175.
8.Neuroprotective effects of INT-777 against Aβ1-42-induced cognitive impairment, neuroinflammation, apoptosis, and synaptic dysfunction in mice. Wu X, Lv YG, Du YF, Chen F, Reed MN, Hu M, Suppiramaniam V, Tang SS, Hong H. Brain Behav Immun, 2018 Oct;73:533-545.
9.Protective Effects of 1-Methylnicotinamide on Aβ1-42-Induced Cognitive Deficits, Neuroinflammation and Apoptosis in Mice.Fu L, Liu C, Chen L, Lv Y, Meng G, Hu M, Long Y, Hong H, Tang S. J Neuroimmune Pharmacol, 2019 Jan 11. doi: 10.1007/s11481-018-09830-1.
10.Inhibitory effect of INT-777 on lipopolysaccharide-induced cognitive impairment, neuroinflammation, apoptosis, and synaptic dysfunction in mice.Wu X, Lv YG, Du YF, Hu M, Reed MN, Long Y, Suppiramaniam V, Hong H, Tang SS. Prog Neuropsychopharmacol Biol Psychiatry. 2019 Jan 10; 88:360-374.