Elizabeth Leadbetter, PhD publishes paper in Cell Metabolism
Congratulations to Dr. Elizabeth Leadbetter for her recently published paper in Cell Metabolism!
Obesity is accompanied by inflammation in adipose tissue, impaired glucose tolerance, and changes in adipose leukocyte populations. These studies of adipose tissue from humans and mice revealed that increased frequencies of T-bet+ B cells in adipose tissue depend on invariant NKT cells and correlate with weight gain during obesity. Transfer of B cells enriched for T-bet+ cells exacerbates metabolic disorder in obesity, while ablation of Tbx21 specifically in B cells reduces serum IgG2c levels, inflammatory cytokines, and inflammatory macrophages in adipose tissue, ameliorating metabolic symptoms. Furthermore, transfer of serum or purified IgG from HFD mice restores metabolic disease in T-bet+ B cell-deficient mice, confirming T-bet+ B cell-derived IgG as a key mediator of inflammation during obesity. Together, these findings reveal an important pathological role for T-bet+ B cells that should inform future immunotherapy design in type 2 diabetes and other inflammatory conditions.
T-bet+ B cells accumulate in adipose tissue and exacerbate metabolic disorder during obesity https://t.co/AHhNCYuplp pic.twitter.com/PsuhdLGUfT
— Cell Metabolism (@Cell_Metabolism) August 4, 2022
More information can be found here:
Thomas Hägglöf, Carlo Vanz, Abigail Kumagai, Elizabeth Dudley, Vanessa Ortega, McKenzie Siller, Raksha Parthasarathy, Josh Keegan, Abigail Koenigs, Travis Shute, and Elizabeth Leadbetter. T-bet+ B cells accumulate in adipose tissue and exacerbate metabolic disorder during obesity Cell Metabolism Vol. 34Issue 8p1121–1136.e6Published online: July 21, 2022 DOI: https://doi.org/10.1016/j.cmet.2022.07.002
https://www.cell.com/cell-metabolism/fulltext/S1550-4131(22)00301-1