Paolo Casali, M.D. publishes paper in Nature Communications
Congratulations to Paolo Casali, MD for this paper recently published in Nature Communications. Summarized in Dr. Casali’s own words:
This paper reports the first “discovery” of the mechanism of class-switch DNA recombination to IgD (by microhomology-mediated DNA end-joining, very different from CSR to IgG, IgA or IgE (by non-homologous DNA end-joining), as well as the very first demonstration of a critical (non-fungible) role of the homologous recombination Rad52 factor in mammalian DNA repair (mouse and human B cells).
More information can be found here:
Xu Y, Zhou H, Post G, Zan H, Casali P. Rad52 mediates class-switch DNA recombination to IgD. Nature Communications. 13: 980. PMID 35190531 DOI: 10.1038/s41467-022-28576-2
https://www.nature.com/articles/s41467-022-28576-2