High Impact Publications
N6-adenosine methylation enhances nuclear mRNA export through METTL3 and NUP93
March 6, 2026
Abstract Nuclear export of messenger RNAs (mRNAs) through nuclear pore complexes (NPCs) is a critical step in gene expression. Although N6-adenosine methylation (m6A) has been implicated in this process, the underlying mechanism remains obscure. Here we demonstrate, using single-molecule imaging, that m6A markedly accelerates the nuclear export of messenger ribonucleoproteins (mRNPs) by increasing export efficiency and […]
Specific Regulation of Mechanical Nociception by Gβ5 Involves GABA-B Receptors
February 28, 2024
Abstract Mechanical, thermal, and chemical pain sensation is conveyed by primary nociceptors, a subset of sensory afferent neurons. The intracellular regulation of the primary nociceptive signal is an area of active study. We report here the discovery of a Gβ5-dependent regulatory pathway within mechanical nociceptors that restrains antinociceptive input from metabotropic GABA-B receptors. In mice […]
Molecular Cell
November 2, 2023
Phagocytosis-initiated tumor hybrid cells acquire a c-Myc-mediated quasi-polarization state for immunoevasion and distant dissemination
November 1, 2023
Abstract While macrophage phagocytosis is an immune defense mechanism against invading cellular organisms, cancer cells expressing the CD47 ligand send forward signals to repel this engulfment. Here we report that the reverse signaling using CD47 as a receptor additionally enhances a pro-survival function of prostate cancer cells under phagocytic attack. Although low CD47-expressing cancer cells […]
Mays Cancer Center: Targeting Certain Molecular Interactions Could Yield New Strategies for Treating Prostate Cancer
October 5, 2023
SAN ANTONIO, Oct. 5, 2023 – Researchers at The University of Texas Health Science Center at San Antonio (UT Health San Antonio) have discovered that altering certain molecular interactions could yield new strategies for treating prostate cancer and related diseases. The study led by scientists with the Mays Cancer Center at UT Health San Antonio focuses […]