2020

Restoring mitochondrial superoxide levels with elamipretide (MTP-131) protects db/db mice against progression of diabetic kidney disease. Miyamoto S, Zhang G, Hall D, Oates PJ, Maity S, Madesh M, Han X, Sharma K. J Biol Chem. 2020 May 22;295(21):7249-7260.  doi: 10.1074/jbc.RA119.011110. PMID: 32277051; PMCID: PMC7247302.

Branched-Chain Amino Acids Depletion during Hemodialysis Is Associated with Fatigue. Debnath S, Lorenzo C, Bansal S, Morales J, Rueda RO, Kasinath BS, Sharma K, O’Connor JC. Am J Nephrol. 2020 Jun 23;:1-7. PMID: 32575099 https://doi.org/10.1159/000507839

Enhancing kidney DDAH-1 expression by adenovirus delivery reduces ADMA and ameliorates diabetic nephropathy. Wetzel MD, Gao T, Stanley K, Cooper TK, Morris SM, Awad AS. Am J Physiol Renal Physiol. 2020 Feb 1;318(2):F509-F517. PMID: 31904280.

Response Surface Methodology as a New Approach for Finding Optimal MALDI Matrix Spraying Parameters for Mass Spectrometry Imaging. Veličković D, Zhang G, Bezbradica D, Bhattacharjee A, Paša-Tolić L, Sharma K, Alexandrov T, Anderton CR, and KPMP Consortium. J Am Soc Mass Spec. 2020 Feb 06;31(3):508-516. doi:10.1021/jasms.9b00074. PMID: 32126772.

DESI-MSI and METASPACE indicates lipid abnormalities and altered mitochondrial membrane components in diabetic renal proximal tubules. 1. Zhang G, Zhang J, DeHoog RJ, Pennathur S, Anderton CR, Venkatachalam MA, Alexandrov T, Eberlin LS, Sharma K. Metabolomics. 2020 Jan 10;16(1):11. doi: 10.1007/s11306-020-1637-8. PMID 31925564.

2019

Triple-negative breast cancer cell line sensitivity to englerin A identifies a new, targetable subtype. Grant CV, Carver CM, Hastings SD, Ramachandran K, Madesh M, Risinger AL, Beutler JA, Mooberry SL. Breast Cancer Research Treatment. 2019 Sep;177(2):345-355.

l-Homoarginine supplementation prevents diabetic kidney damage. Wetzel MD, Gao T, Venkatachalam M, Morris SM Jr, Awad AS. Physiol Rep. 2019 Sep;7(18):e14235. doi: 10.14814/phy2.14235. PMID: 31552707

Dual peroxisome-proliferator-activated-receptor-α/γ activation inhibits SIRT1-PGC1α axis and causes cardiac dysfunction. Kalliora C, Kyriazis ID, Oka SI, Lieu MJ, Yue Y, Area-Gomez E, Pol CJ, Tian Y, Mizushima W, Chin A, Scerbo D, Schulze PC, Civelek M, Sadoshima J, Madesh M, Goldberg IJ, Drosatos K. Journal of Clinical Investigation Insight. 2019 Aug 8;5. pii: 129556.

Mitochondrial dysfunction in human primary alveolar type II cells in emphysema. Kosmider B, Lin CR, Karim L, Tomar D, Vlasenko L, Marchetti N, Bolla S, Madesh M, Criner GJ, Bahmed K. American Journal of Physiology. 2019 Aug; 46:305-316. doi: 10.1016/j.ebiom.2019.07.063.

The role of DJ-1 in human primary alveolar type II cell injury induced by e-cigarette aerosol. Bahmed K, Lin CR, Simborio H, Karim L, Aksoy M, Kelsen S, Tomar D, Madesh M, Elrod JW, Messier E, Mason RJ, Unterwald EM, Eisenstein TK, Criner GJ, Kosmider B. American Journal of Physiology.  2019 Jul 17. doi: 10.1152/ajplung.00567.2018.

The relationship between DJ-1 and S100A8 in human primary alveolar type II cells in emphysema. Lin CR, Bahmed K, Tomar D, Marchetti N, Criner GJ, Bolla S, Wilson MA, Madesh M, Kosmider B. American Journal of Physiology. 2019 Jul 17. doi:10.1152/ajplung.00494.2018.

AKI Associated with Acute Pancreatitis. Tareq I. Nassar, MD; Wajeh Y. Qunibi, MD. Clin J Am Soc Nephrol. 2019 Jul 5;14(7):1106-1115. PMID: 31118209

High glucose increases miR-214 to power a feedback loop involving PTEN and the Akt/mTORC1 signaling axis. Maity S, Das F, Ghosh-Choudhury N, Kasinath BS, Ghosh Choudhury G. FEBS Lett. 2019 Aug;593(16):2261-2272. doi: 10.1002/1873-3468.13505. Epub 2019 Jul 4. PMID: 31240704

Complex I and II are required for normal mitochondrial Ca2+ homeostasis. Jaña F, Bustos G, Rivas J, Cruz P, Urra F, Basualto-Alarcón C, Sagredo E, Ríos M, Lovy A, Dong Z, Cerda O, Madesh M, and Cárdenas C. Mitochondrion. 2019 Jul 13;49:73-82.

High-Dose Spironolactone When Patients With Acute Decompensated Heart Failure Are Resistant to Loop Diuretics: A Pilot Study. Shweta Bansal, MD; Kristina Munoz, BS; Sonja Brune, MSN; Steven Bailey, MD; Anand Prasad, MD; Chakradhar Velagapudi, Ph. Annals of Internal Medicine. Online 2019 July 16; PMID: 31307058

Mitochondrial dysfunction in human immunodeficiency virus-1 transgenic mouse cardiac myocytes. Cheung JY, Gordon J, Wang J, Song J, Zhang XQ, Prado FJ, Shanmughapriya S, Rajan S, Tomar D, Tahrir FG, Gupta MK, Knezevic T, Merabova N, Kontos CD, McClung JM, Klotman PE, Madesh M, Khalili K, Feldman AM. Journal of Cellular Physiology. 2019 Apr;234(4):4432-4444.

Deacetylation of S6 kinase promotes high glucose-induced glomerular mesangial cell hypertrophy and matrix protein accumulation. Das F, Maity S, Ghosh-Choudhury N, Kasinath BS, Ghosh Choudhury G. J Biol Chem. 2019 Jun 14;294(24):9440-9460. doi: 10.1074/jbc.RA118.007023. Epub 2019 Apr 26. PMID: 31028173

Marmoset as a Model to Study Kidney Changes Associated with Aging. Hak Joo Lee, Olga Gonzalez, Edward J. Dick, Jr, Andrew Donati, Denis Feliers, Goutam Ghosh Choudhury, Corinna Ross, Manjeri Venkatachalam, Suzette D. Tardif, Balakuntalam S. Kasinath. J Gerontol A Biol Sci Med Sci. 2019 Feb 15;74(3):315-324. PMID: 30321310

Management of calciphylaxis in a burn center: A case series and review of the literature. Dado DN, Huang B, Foster DV, Nielsen JS, Gurney JM, Morrow BD, Sharma K, Chung KK, Ainsworth CR. Burns. 2019 Feb;45(1):241-246. PMID: 30322738

Chemically synthesized Secoisolariciresinol diglucoside (LGM2605) improves mitochondrial function in cardiac myocytes and alleviates septic cardiomyopathy. Kokkinaki D, Hoffman M, Kalliora C, Kyriazis ID, Maning J, Lucchese AM, Shanmughapriya S, Tomar D, Park JY, Wang H, Yang XF, Madesh M, Lymperopoulos A, Koch WJ, Christofidou-Solomidou M, Drosatos K. J Mol Cell Cardiol. 2019 Feb;127:232-245. PMID: 30611795

Impaired non-homologous end joining in human primary alveolar type II cells in emphysema. Kosmider B, Lin CR, Vlasenko L, Marchetti N, Bolla S, Criner GJ, Messier E, Reisdorph N, Powell RL, Madesh M, Kelsen S, Xander N, Correll KA, Mason RJ, Bahmed K. Sci Rep. 2019 Jan 29;9(1):920. PMID: 30696938

A Selective and Cell-Permeable Mitochondrial Calcium Uniporter (MCU) Inhibitor Preserves Mitochondrial Bioenergetics after Hypoxia/Reoxygenation Injury. Woods JJ, Nemani N, Shanmughapriya S, Kumar A, Zhang M, Nathan SR, Thomas M, Carvalho E, Ramachandran K, Srikantan S, Stathopulos PB, Wilson JJ, Madesh M. ACS Cent Sci. 2019 Jan 23;5(1):153-166. PMID: 30693334

Myofibroblasts acquire retinoic acid-producing ability during fibroblast-to-myofibroblast transition following kidney injury. Nakamura J, Sato Y, Kitai Y, Wajima S, Yamamoto S, Oguchi A, Yamada R, Kaneko K, Kondo M, Uchino E, Tsuchida J, Hirano K, Sharma K, Kohno K, Yanagita M. Kidney Int. 2019 Jan 16. pii: S0085-2538(18)30806-8. PMID: 30661714

Trpm2 enhances physiological bioenergetics and protects against pathological oxidative cardiac injury: Role of Pyk2 phosphorylation. Miller BA, Wang J, Song J, Zhang XQ, Hirschler-Laszkiewicz I, Shanmughapriya S, Tomar D, Rajan S, Feldman AM, Madesh M, Sheu SS, Cheung JY. J Cell Physiol. 2019 Jan 13. PMID: 30637731

Effects of General Anesthesia on 2 Urinary Biomarkers of Kidney Injury-Hepatitis A Virus Cellular Receptor 1 and Lipocalin 2-in Male C57BL/6J Mice. Gibbs KM, Izer JM, Reeves WB, Wilson RP, Cooper TK. J Am Assoc Lab Anim Sci. 2019 Jan 1;58(1):21-29.  PMID: 30538007

Sex-Related Disparities in CKD Progression.Ricardo AC, Yang W, Sha D, Appel LJ, Chen J, Krousel-Wood M, Manoharan A, Steigerwalt S, Wright J, Rahman M, Rosas SE, Saunders M, Sharma K, Daviglus ML, Lash JP; CRIC Investigators. J Am Soc Nephrol. 2019 Jan;30(1):137-146. PMID: 30510134

2018

Efficacy of a novel inhibitor of vascular adhesion protein-1 in reducing albuminuria in patients with diabetic kidney disease (ALBUM): a randomised, placebo-controlled, phase 2 trial. de Zeeuw D, Renfurm RW, Bakris G, Rossing P, Perkovic V, Hou FF, Nangaku M, Sharma K, Heerspink HJL, Garcia-Hernandez A, Larsson TE. Lancet Diabetes Endocrinol. 2018 Dec;6(12):925-933. PMID: 30413396

Akt2 causes TGFβ-induced deptor downregulation facilitating mTOR to drive podocyte hypertrophy and matrix protein expression. Das F, Ghosh-Choudhury N, Lee DY, Gorin Y, Kasinath BS, Choudhury GG. PLoS One. 2018 Nov 16;13(11):e0207285. PMID: 30444896

Self-reported Intentional Weight Loss and Risk of Death in Moderate Chronic Kidney Disease in the United States.  Bansal S, Wei G, Boucher RE, Beddhu S.  J Ren Nutr. 2018 Nov;28(6):422-427. PMID: 30077396

Marmoset as a model to study kidney changes associated with aging. Lee HJ, Gonzalez O, Dick EJ Jr, Donati A, Feliers D, Goutam Ghosh C, Ross C, Venkatachalam M, Tardif SD, Kasinath BS. J Gerontol A Biol Sci Med Sci. 2018 Oct 13. PMID: 30321310

Mitochondrial fusion and Bid-mediated mitochondrial apoptosis are perturbed by alcohol with distinct dependence on its metabolism. Naghdi S, Slovinsky WS, Madesh M, Rubin E, Hajnóczky G. Cell Death & Diseases. 2018 Oct 9;9(10):1028.

Mitochondrial fusion and Bid-mediated mitochondrial apoptosis are perturbed by alcohol with distinct dependence on its metabolism. Naghdi S, Slovinsky WS, Madesh M, Rubin E, Hajnóczky G. Cell Death & Disease 2018 Oct 9;9(10):1028.

Physical Function Following a Long-Term Lifestyle Intervention Among Middle Aged and Older Adults With Type 2 Diabetes: The Look AHEAD Study. Houston DK, Neiberg RH, Miller ME, Hill JO, Jakicic JM, Johnson KC, Gregg EW, Hubbard VS, Pi-Sunyer X, Rejeski WJ, Wing RR, Bantle JP, Beale E, Berkowitz RI, Cassidy-Begay M, Clark JM, Coday M, Delahanty LM, Dutton G, Egan C, Foreyt JP, Greenway FL, Hazuda HP, Hergenroeder A, Horton ES, Jeffery RW, Kahn SE, Kure A, Knowler WC, Lewis CE, Martin CK, Michaels S, Montez MG, Nathan DM, Patricio J, Peters A, Pownall H, Regensteiner J, Steinburg H, Wadden TA, White K, Yanovski SZ, Zhang P, Kritchevsky SB. J Gerontol A Biol Sci Med Sci. 2018 Oct 8;73(11):1552-1559. PMID: 29053861

Association of Variants in BAG3 With Cardiomyopathy Outcomes in African American Individuals. Myers VD, Gerhard GS, McNamara DM, Tomar D, Madesh M, Kaniper S, Ramsey FV, Fisher SG, Ingersoll RG, Kasch-Semenza L, Wang J, Hanley-Yanez K, Lemster B, Schwisow JA, Ambardekar AV, Degann SH, Bristow MR, Sheppard R, Alexis JD, Tilley DG, Kontos CD, McClung JM, Taylor AL, Yancy CW, Khalili K, Seidman JG, Seidman CE, McTiernan CF, Cheung JY, Feldman AM. JAMA Cardiol. 2018 Oct 1;3(10):929-938. PMID: 30140897

The human ion channel TRPM2 modulates neuroblastoma cell survival and mitochondrial function through Pyk2, CREB, and MCU activation. Hirschler-Laszkiewicz I, Chen SJ, Bao L, Wang J, Zhang XQ, Shanmughapriya S, Keefer K, Madesh M, Cheung JY, Miller BA. Am J Physiol Cell Physiol. 2018 Oct 1;315(4):C571-C586. PMID: 30020827

Methylene Blue Counteracts H2S-Induced Cardiac Ion Channel Dysfunction and ATP Reduction. Cheung JY, Wang J, Zhang XQ, Song J, Davidyock JM, Prado FJ, Shanmughapriya S, Worth AM, Madesh M, Judenherc-Haouzi A, Haouzi P. Cardiovasc Toxicol. 2018 Oct;18(5):407-419. PMID: 29603116

Haplo-insufficiency of Bcl2-associated athanogene 3 in mice results in progressive left ventricular dysfunction, β-adrenergic insensitivity, and increased apoptosis. Myers VD, Tomar D, Madesh M, Wang J, Song J, Zhang XQ, Gupta MK, Tahrir FG, Gordon J, McClung JM, Kontos CD, Khalili K, Cheung JY, Feldman AM. J Cell Physiol. 2018 Sep; 233(9):6319-6326. PMID: 29323723

Molecular regulation of MCU: Implications in physiology and disease. Nemani N, Shanmughapriya S, Madesh M. Cell Calcium. 2018 Sep; 74:86-93. Review. PMID: 29980025

A new drug combination significantly reduces kidney tumor progression in kidney mouse model. Liang S, Cuellar T, Nowacki M, Nayak BK, Dong L, Li B, Sharma K, Habib SL. Oncotarget. 2018 Aug 31;9(68):3. PMID: 30250638 2900-32916.

FOXD1-dependent MICU1 expression regulates mitochondrial activity and cell differentiation. Shanmughapriya S, Tomar D, Dong Z, Slovik KJ, Nemani N, Natarajaseenivasan K, Carvalho E, Lu C, Corrigan K, Garikipati VNS, Ibetti J, Rajan S, Barrero C, Chuprun K, Kishore R, Merali S, Tian Y, Yang W, Madesh M. Nat Commun. 2018 Aug 29;9(1):3449. PMID: 30158529

Elevated lipoxygenase and cytochrome P450 products predict progression of chronic kidney disease. Afshinnia F, Zeng L, Byun J, Wernisch S, Deo R, Chen J, Hamm L, Miller ER, Rhee EP, Fischer MJ, Sharma K, Feldman HI, Michailidis G, Pennathur S; CRIC Study Investigators. Nephrol Dial Transplant. 2018 Jul 25. PMID: 30137494

Inferring Identical-by-Descent Sharing of Sample Ancestors Promotes High-Resolution Relative Detection. Ramstetter MD, Shenoy SA, Dyer TD, Lehman DM, Curran JE, Duggirala R, Blangero J, Mezey JG, Williams AL. Am J Hum Genet. 2018 Jul 5;103(1):30-44. PMID: 29937093

Toward individual glomerular phenotyping: advent of precision medicine in kidney biopsies. Sharma K, Paša-Tolić L. Kidney Int. 2018 Jun;93(6):1265-1267. PMID: 29792268

Genetic and environmental (physical fitness and sedentary activity) interaction effects on cardiometabolic risk factors in Mexican American children and adolescents. Arya R, Farook VS, Fowler SP, Puppala S, Chittoor G, Resendez RG, Mummidi S, Vanamala J, Almasy L, Curran JE, Comuzzie AG, Lehman DM, Jenkinson CP, Lynch JL, DeFronzo RA, Blangero J, Hale DE, Duggirala R, Diego VP. Genet Epidemiol. 2018 Jun;42(4):378-393 PMID: 29460292

Computational Modeling of Exciton-Bath Hamiltonians for Light Harvesting 2 and Light Harvesting 3 Complexes of Purple Photosynthetic Bacteria at Room Temperature. Montemayor D, Rivera E, Jang SJ. J Phys Chem B. 2018 Apr 2;122(14):3815-3825. PMID: 29533664

Hydrogen sulfide ameliorates aging-associated changes in the kidney.Lee HJ, Feliers D, Barnes JL, Oh S, Choudhury GG, Diaz V, Galvan V, Strong R, Nelson J, Salmon A, Kevil CG, Kasinath BS. Biochem Pharmacol. 2018 Mar;149:29-41. PMID: 29225129

Chemically synthesized Secoisolariciresinol diglucoside (LGM2605) improves mitochondrial function in cardiac myocytes and alleviates septic cardiomyopathy. Kokkinaki D, Hoffman M, Kalliora C, Kyriazis ID, Maning J, Lucchese AM, Shanmughapriya S, Tomar D, Park JY, Wang H, Yang XF, Madesh M, Lymperopoulos A, Koch WJ, Christofidou-Solomidou M, Drosatos K. Journal of Molecular Cellular Cardiology. 2019 Feb;127:232-245.

Nox4 is a Target for Tuberin Deficiency Syndrome. Shi Q, Viswanadhapalli S, Friedrichs WE, Velagapudi C, Szyndralewiez C, Bansal S, Bhat MA, Choudhury GG, Abboud HE. Sci Rep. 2018 Feb 28;8(1):3781.  PMID: 29491408

Neutrophil peptidyl arginine deiminase-4 has a pivotal role in ischemia/reperfusion-induced acute kidney injury. Raup-Konsavage WM, Wang Y, Wang WW, Feliers D, Ruan H, Reeves WB. Kidney Int. 2018 Feb;93(2):365-374. PMID: 29061334.

microRNA-181a downregulates deptor for TGFβ-induced glomerular mesangial cell hypertrophy and matrix protein expression. Maity S, Bera A, Ghosh-Choudhury N, Das F, Kasinath BS, Choudhury GG. Exp Cell Res. 2018 Mar 1;364(1):5-15. doi: 10.1016/j.yexcr.2018.01.021. Epub 2018 Feb 1. PMID: 29397070

Impaired non-homologous end joining in human primary alveolar type II cells in emphysema. Kosmider B, Lin CR, Vlasenko L, Marchetti N, Bolla S, Criner GJ, Messier E, Reisdorph N, Powell RL, Madesh M, Kelsen S, Xander N, Correll KA, Mason RJ, Bahmed K. Scientific Reports. 2019 Jan 29;9(1):920.

A Selective and Cell-Permeable Mitochondrial Calcium Uniporter (MCU) Inhibitor Preserves Mitochondrial Bioenergetics after Hypoxia/Reoxygenation Injury. Woods JJ, Nemani N, Shanmughapriya S, Kumar A, Zhang M, Nathan SR, Thomas M, Carvalho E, Ramachandran K, Srikantan S, Stathopulos PB, Wilson JJ, Madesh M.  ACS Central Sciences. 2019 Jan 23;5(1):153-166.

Trpm2 enhances physiological bioenergetics and protects against pathological oxidative cardiac injury: Role of Pyk2 phosphorylation. Miller BA, Wang J, Song J, Zhang XQ, Hirschler-Laszkiewicz I, Shanmughapriya S, Tomar D, Rajan S, Feldman AM, Madesh M, Sheu SS, Cheung JY. Journal of Cellular Physiology. 2019 Jan 13. doi: 10.1002/jcp.28146.

Tyrosines-740/751 of PDGFRβ contribute to the activation of Akt/Hif1α/TGFβ nexus to drive high glucose-induced glomerular mesangial cell hypertrophy. Das F, Ghosh-Choudhury N, Kasinath BS, Choudhury GG. Cell Signal. 2018 Jan;42:44-53. PMID: 28951244

Vascular access mortality and hospitalization among hemodialysis patients in Palestine. Hamadneh SA, Nueirat SA, Qadoomi’ J, Shurrab M, Qunibi WY, Hamdan Z. Saudi J Kidney Dis Transpl. 2018 Jan-Feb;29(1):120-126. PMID: 29456217